Mapping on Human and Mouse Chromosomes of the Gene for the β-Galactoside-Binding Protein, an Autocrine-Negative Growth Factor

• Published in: Genomics (San Diego, Calif.) Vol. 15; no. 1; pp. 216 - 218
• Main Authors: Baldini, Antonio, Gress, Thomas, Patel, Ketan, Muresu, Rosella, Chiariotti, Lorenzo, Williamson, Penny, Boyd, Yvonne, Casciano, Ida, Wells, Valerie, Bruni, Carmelo B., Mallucci, Livio, Siniscalco, Marcello
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 1993; Elsevier
• Subjects: Animals; Biological and medical sciences; Biological Evolution; Chromosome Mapping; Chromosomes, Human, Pair 22; Classical genetics, quantitative genetics, hybrids; Fundamental and applied biological sciences. Psychology; Galactosides; Galectins; Genetics of eukaryotes. Biological and molecular evolution; Hemagglutinins - genetics; Human; Humans; In Situ Hybridization, Fluorescence; Mice; Platelet-Derived Growth Factor - genetics; Protein-Tyrosine Kinases - metabolism; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins c-sis; Genetic mapping; Human; Binding protein; Vertebrata; Mammalia; Mouse; Rodentia; Glycoside; Galactose; G22-Chromosome; Growth factor
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1993.1039

The structural gene for β-galactoside-binding protein (Lgals-1), a cell growth regulatory molecule and cystostatic factor, is assigned to the E-region of mouse chromosome 15 and to the region q12-q13.1 of human chromosome 22. The evolutionary conservation of these two regions has been previously suggested from comparative mapping of several loci. These include the murine SIS oncogene (Pdgfb) and its human homolog, the platelet-derived growth factor-β polypeptide, PDGFB. The findings presented here extend the genetic homology of the two regions.