Intermediates caught in the act: tracing insulin amyloid fibril formation in time by combined optical spectroscopy, light scattering, mass spectrometry and microscopy

• Published in: Physical chemistry chemical physics : PCCP Vol. 17; no. 2; pp. 918 - 927
• Main Authors: Gladytz, A, Lugovoy, E, Charvat, A, Häupl, T, Siefermann, K. R, Abel, B
• Format: Journal Article
• Language: English
• Published: England 14.01.2015
• Subjects: Agglomeration; Amyloid - chemistry; Animals; Cattle; Diseases; Formations; Insulin; Insulin - chemistry; Light; Mass Spectrometry; Microscopy; Molecular structure; Oligomers; Peptides; Protein Aggregates; Protein Multimerization; Protein Structure, Secondary; Proteins; Scattering, Radiation

Interest in the topic of amyloid formation by peptides and proteins has increased dramatically in recent years, transforming it from a puzzling phenomenon associated with a small number of diseases into a major subject of study in disciplines ranging from material science to biology and medicine. Th...