Structures and functions of human placental aromatase and steroid sulfatase, two key enzymes in estrogen biosynthesis

• Published in: Steroids Vol. 196; p. 109249
• Main Author: Ghosh, Debashis
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2023
• Subjects: Androgens - metabolism; Aromatase; Aromatase - metabolism; Breast cancer; Conjugated steroid; Dehydroepiandrosterone; Dihydrotestosterone; Endometriosis; Estradiol; Estriol; Estrogens - metabolism; Estrone; Female; Humans; Membrane Proteins; Placenta - metabolism; Pregnancy; Prostate cancer; Reproductive steroid hormone; Sex steroid hormone; Steroid sulfate; Steryl-Sulfatase; Structure–function relationship; Testosterone; DHEA; MPD; RES; CPR; TX; HFG; E1; ADP; E2; E3; STS; PO4; 17HSD1; rms; BOG; 3HSD; TBS; Structure–function relationship; Endometriosis; ER; AR; Dehydroepiandrosterone; FGS; TCA; TST; RAAP; Reproductive steroid hormone; NADPH; aromatase/AROM; C; E1S; Em; BDM; ANZ; Estradiol; N; ASD; Dihydrotestosterone; DHEAS; LTZ; Aromatase; 17HSD3/5; Estriol; DLPC; dpm; Conjugated steroid; Breast cancer; EDTA; rpm; mAb; 5R1/R1; Testosterone; Con-A; PEG; NAG; HA; Estrone; EXM; Sex steroid hormone; ATP; Steroid sulfate; Prostate cancer

[Display omitted] •Aromatase and steroid sulfatase are two key enzymes for the biosynthesis of estrogen and androgen.•Both enzymes were purified to homogeneity from human placenta and studied.•Important findings on their structure–function relationships are reviewed in this article. Cytochrome P450...