NMR three-dimensional structure of the cationic peptide Stigmurin from Tityus stigmurus scorpion venom: In vitro antioxidant and in vivo antibacterial and healing activity

• Published in: Peptides (New York, N.Y. : 1980) Vol. 137; p. 170478
• Main Authors: Daniele-Silva, Alessandra, Rodrigues, Suedson de Carvalho Silva, dos Santos, Elizabeth Cristina Gomes, Queiroz Neto, Moacir Fernandes de, Rocha, Hugo Alexandre de Oliveira, Silva-Júnior, Arnóbio Antônio da, Resende, Jarbas Magalhães, Araújo, Renata Mendonça, Fernandes-Pedrosa, Matheus de Freitas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2021
• Subjects: Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antimicrobial; Antimicrobial Cationic Peptides - pharmacology; Antioxidant activity; Antioxidants - chemistry; Antioxidants - pharmacology; Humans; Magnetic Resonance Spectroscopy; NMR structure; Protein Conformation; Scorpion venom; Scorpion Venoms - chemistry; Scorpion Venoms - genetics; Scorpions - chemistry; Staphylococcus aureus - drug effects; Staphylococcus aureus - pathogenicity; Wound Infection - drug therapy; Wound Infection - microbiology; Antimicrobial; NMR structure; Scorpion venom; Antioxidant activity

[Display omitted] •Stigmurin showed high hydroxyl radical scavenging activity in vitro.•Stigmurin revelad antibiotic effect in the model of skin wound infection.•Stigmurin increased the retraction rate of the skin lesion in vivo.•Stigmurin showed an amphipathic helical structure with a flexible N-te...