Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations - Wang, Yiying; Le, Yuan; Harris, Kelly L.; Chen, Ying; Li, Xilin; Faske, Jennifer; Wynne, Rebecca A.; Mittelstaedt, Roberta A.; Cao, Xuefei; Miranda-Colon, Jaime; Elkins, Lana; Muskhelishvili, Levan; et al. (Mutation research. Genetic toxicology and environmental mutagenesis, 2024)
Keywords: Bronchi - cytology; Bronchi - drug effects; DNA damage; DNA Damage - drug effects; Error-corrected next generation sequencing (ecNGS); Ethyl methanesulfonate (EMS); Ethyl Methanesulfonate - pharmacology; Ethyl Methanesulfonate - toxicity; Human in vitro organotypic air-liquid-interface (ALI) airway tissue model; Humans; Mutagenesis; Mutagenesis - drug effects; Mutagens - toxicity; Mutation - drug effects; New approach methods (NAMs); New approach methods (NAMs); Mutagenesis; Human in vitro organotypic air-liquid-interface (ALI) airway tissue model; DNA damage; Ethyl methanesulfonate (EMS); Error-corrected next generation sequencing (ecNGS)