Synthesis of diblock functional poly(ɛ-caprolactone) amphiphilic copolymers grafted with bioactive molecules and characterization of their micelles

• Published in: Polymer journal Vol. 45; no. 9; pp. 962 - 970
• Main Authors: Huang, Yi-Ting, Peng, Kang-Yu, Chiu, Fang-Chyou, Lee, Ren-Shen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2013; Nature Publishing Group
• Subjects: 639/638/455/941; 639/925/352/152; Biomaterials; Bioorganic Chemistry; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Copolymers; Fourier transforms; Graft copolymers; Grafting; Infrared spectroscopy; Melting; Micelles; original-article; Polymer Sciences; Surfaces and Interfaces; Synthesis; Thin Films; click chemistry; graft-block functional polyester; bioactive molecules; micelles; amphiphilic

In this study, the grafting of an alkynyl bioactive compound to poly(α-azo-ɛ-caprolactone)- b -poly(ɛ-caprolactone) (PαN 3 CL- b -PCL) was performed using Huisgen’s 1,3-dipolar cycloaddition, also known as click chemistry. The grafted copolymers were successfully obtained at various ratios, as confi...