Amino acid changes in HA and determinants of pathogenicity associated with influenza virus A H1N1pdm09 during the winter seasons 2015-2016 and 2016-2017 in Mexico
•H1N1pdm09 belonging to clade 6B.1 instead of H3N2 were detected in Mexico in 2017.•A new glycosylation site in HA (S162 N) may affect the efficacy of the current vaccine.•The new insertion Ile113 in NS1 may strengthen the interaction with CPSF30. Biennial H1N1pdm09 influenza A virus (IAV) epidemics...
Saved in:
Published in | Virus research Vol. 272; p. 197731 |
---|---|
Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
15.10.2019
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | •H1N1pdm09 belonging to clade 6B.1 instead of H3N2 were detected in Mexico in 2017.•A new glycosylation site in HA (S162 N) may affect the efficacy of the current vaccine.•The new insertion Ile113 in NS1 may strengthen the interaction with CPSF30.
Biennial H1N1pdm09 influenza A virus (IAV) epidemics have been associated with major severity of respiratory disease in Mexico. Atypically and in contrast with what happened in USA, Canada and Europe during 2017, an increase of infections due to the H1N1pdm09 pandemic virus instead of H3N2 was observed. In order to determine the viral contribution to severe acute respiratory disease, we characterized the pathogenicity determinants of IAV in Mexico during the 2015–2016 and 2016–2017 seasons. The RNA segments of 20 IAV samples were sequenced by NGS platform and phylogenetic analysis was conducted. The analysis of the hemagglutinin (HA) sequences established that all virus samples, except one, belong to clade (6B.1). The IAVs presented the substitution S162 N, which introduces a new glycosylation site in the hemagglutinin. We also found the D222 G substitution, which has been associated with a higher tropism towards the lower respiratory tract, and a non-reported insertion of one Ile in NS1 (Ile113). The IAVs from 2016 to 2017 in Mexico belong to the new clade 6B.1. The new glycosylation site in HA (S162 N) is a major change that may affect the efficacy of the current vaccine. We detected in several patients pathogenicity determinants associated with the severity of the respiratory disease. |
---|---|
AbstractList | •H1N1pdm09 belonging to clade 6B.1 instead of H3N2 were detected in Mexico in 2017.•A new glycosylation site in HA (S162 N) may affect the efficacy of the current vaccine.•The new insertion Ile113 in NS1 may strengthen the interaction with CPSF30.
Biennial H1N1pdm09 influenza A virus (IAV) epidemics have been associated with major severity of respiratory disease in Mexico. Atypically and in contrast with what happened in USA, Canada and Europe during 2017, an increase of infections due to the H1N1pdm09 pandemic virus instead of H3N2 was observed. In order to determine the viral contribution to severe acute respiratory disease, we characterized the pathogenicity determinants of IAV in Mexico during the 2015–2016 and 2016–2017 seasons. The RNA segments of 20 IAV samples were sequenced by NGS platform and phylogenetic analysis was conducted. The analysis of the hemagglutinin (HA) sequences established that all virus samples, except one, belong to clade (6B.1). The IAVs presented the substitution S162 N, which introduces a new glycosylation site in the hemagglutinin. We also found the D222 G substitution, which has been associated with a higher tropism towards the lower respiratory tract, and a non-reported insertion of one Ile in NS1 (Ile113). The IAVs from 2016 to 2017 in Mexico belong to the new clade 6B.1. The new glycosylation site in HA (S162 N) is a major change that may affect the efficacy of the current vaccine. We detected in several patients pathogenicity determinants associated with the severity of the respiratory disease. Biennial H1N1pdm09 influenza A virus (IAV) epidemics have been associated with major severity of respiratory disease in Mexico. Atypically and in contrast with what happened in USA, Canada and Europe during 2017, an increase of infections due to the H1N1pdm09 pandemic virus instead of H3N2 was observed. In order to determine the viral contribution to severe acute respiratory disease, we characterized the pathogenicity determinants of IAV in Mexico during the 2015-2016 and 2016-2017 seasons. The RNA segments of 20 IAV samples were sequenced by NGS platform and phylogenetic analysis was conducted. The analysis of the hemagglutinin (HA) sequences established that all virus samples, except one, belong to clade (6B.1). The IAVs presented the substitution S162 N, which introduces a new glycosylation site in the hemagglutinin. We also found the D222 G substitution, which has been associated with a higher tropism towards the lower respiratory tract, and a non-reported insertion of one Ile in NS1 (Ile113). The IAVs from 2016 to 2017 in Mexico belong to the new clade 6B.1. The new glycosylation site in HA (S162 N) is a major change that may affect the efficacy of the current vaccine. We detected in several patients pathogenicity determinants associated with the severity of the respiratory disease. |
ArticleNumber | 197731 |
Author | Téllez-Navarrete, Norma Angélica Jiménez-Juárez, Rodolfo Norberto Sánchez-Huerta, José Luis Campos, Fernando Pérez-Padilla, Rogelio Guadarrama-Pérez, Cristóbal Sandoval, José Luis Vega-Sánchez, Ángel Emmanuel Gutiérrez-González, Luis Horacio De La Rosa-Zamboni, Daniela Vázquez-Pérez, Joel Armando Pérez-Méndez, Brenda Berenice Castillejos-López, Manuel |
Author_xml | – sequence: 1 givenname: Joel Armando surname: Vázquez-Pérez fullname: Vázquez-Pérez, Joel Armando email: joevazpe@gmail.com organization: Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico – sequence: 2 givenname: Daniela surname: De La Rosa-Zamboni fullname: De La Rosa-Zamboni, Daniela organization: Hospital Infantil de México Federico Gómez, Mexico City, Mexico – sequence: 3 givenname: Ángel Emmanuel surname: Vega-Sánchez fullname: Vega-Sánchez, Ángel Emmanuel organization: Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico – sequence: 4 givenname: Luis Horacio surname: Gutiérrez-González fullname: Gutiérrez-González, Luis Horacio organization: Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico – sequence: 5 givenname: Norma Angélica surname: Téllez-Navarrete fullname: Téllez-Navarrete, Norma Angélica organization: Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico – sequence: 6 givenname: Fernando surname: Campos fullname: Campos, Fernando organization: Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico – sequence: 7 givenname: Cristóbal surname: Guadarrama-Pérez fullname: Guadarrama-Pérez, Cristóbal organization: Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico – sequence: 8 givenname: José Luis surname: Sandoval fullname: Sandoval, José Luis organization: Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico – sequence: 9 givenname: Manuel surname: Castillejos-López fullname: Castillejos-López, Manuel organization: Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico – sequence: 10 givenname: Rodolfo Norberto surname: Jiménez-Juárez fullname: Jiménez-Juárez, Rodolfo Norberto organization: Hospital Infantil de México Federico Gómez, Mexico City, Mexico – sequence: 11 givenname: José Luis surname: Sánchez-Huerta fullname: Sánchez-Huerta, José Luis organization: Hospital Infantil de México Federico Gómez, Mexico City, Mexico – sequence: 12 givenname: Brenda Berenice surname: Pérez-Méndez fullname: Pérez-Méndez, Brenda Berenice organization: Hospital Infantil de México Federico Gómez, Mexico City, Mexico – sequence: 13 givenname: Rogelio surname: Pérez-Padilla fullname: Pérez-Padilla, Rogelio organization: Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31445105$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkc1uGyEUhVGVKHF-XiFi2c24_Hlm2NWK2jpS2m6yRxguNpYHXGDSpI_TJw0TJ912Axfpu_cc7rlAJyEGQOiGkjkltP20mz_6NOYEec4IlXMqu47TD2hG-441nZDsBM0q2De0I-wcXeS8I4S0vGvP0DmnQiwoWczQ3-XgQ8TaeIvNVocNZOwDXi2xDhZbKJAqoEPJODp80GUbNxC88eUZ65yj8bqAxb992dY-tx8h_NH41Rte4hX9QQ92IBLbMfmwwWULlQ11Ks6gcwwZV_uLph7tq-JUTK9ucvEdnryJV-jU6X2G67f7Ej18_fJwu2ruf367u13eN4a3fWksB6edZcwJRnsppRVMcKb7uq91T9zaSaKpsEA7IaBWXPaul4QSt4BO8Ev08Tj2kOKvEXJRg88G9nsdII5ZMdbzurJW0Iq2R9SkmGsGTh2SH3R6VpSoKR61U-_xqCkedYynNt68aYzrAey_tvc8KvD5CED96KOHpLLxEAxYn8AUZaP_n8YLzfOknQ |
CitedBy_id | crossref_primary_10_1016_j_diabres_2019_107949 crossref_primary_10_1007_s10096_020_04020_5 crossref_primary_10_3390_genes13050909 crossref_primary_10_1186_s12985_023_01979_3 crossref_primary_10_1007_s11262_020_01822_9 |
Cites_doi | 10.1371/journal.pone.0063098 10.1371/journal.pone.0180419 10.1093/cid/cix468 10.1093/aje/kwv054 10.1073/pnas.1409171111 10.1128/JVI.02581-06 10.1073/pnas.1320524110 10.1186/1743-422X-10-41 10.1371/journal.pone.0050116 10.1016/S1097-2765(00)80099-4 10.1128/JVI.00081-10 10.1007/s00705-014-2179-z |
ContentType | Journal Article |
Copyright | 2019 Elsevier B.V. Copyright © 2019 Elsevier B.V. All rights reserved. |
Copyright_xml | – notice: 2019 Elsevier B.V. – notice: Copyright © 2019 Elsevier B.V. All rights reserved. |
DBID | NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.virusres.2019.197731 |
DatabaseName | PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 1872-7492 |
EndPage | 197731 |
ExternalDocumentID | 10_1016_j_virusres_2019_197731 31445105 S0168170219301029 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- --K --M .~1 0R~ 0SF 123 1B1 1RT 1~. 1~5 4.4 457 4G. 5RE 5VS 7-5 71M 8P~ 9JM AAAJQ AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARKO AAXUO ABBQC ABFRF ABJNI ABLVK ABMAC ABMZM ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGEKW AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BLXMC BNPGV CJTIS CNWQP CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IH2 IHE J1W KOM LCYCR LUGTX M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG ROL RPM RPZ SCC SDF SDG SDP SES SIN SPCBC SSH SSI SSZ T5K WH7 ~G- AAHBH AAXKI AFJKZ AKRWK NPM .GJ 29Q 53G AAQXK AAYXX ABFNM ABXDB ADMUD ADVLN AHHHB ASPBG AVWKF AZFZN CITATION FEDTE FGOYB G-2 GROUPED_DOAJ HMG HVGLF HZ~ R2- SEW WUQ ZGI 7X8 |
ID | FETCH-LOGICAL-c368t-d3efafd22f4218999d42432a8101b80fbf90a14de1744ea14398f89010f5e743 |
IEDL.DBID | AIKHN |
ISSN | 0168-1702 |
IngestDate | Fri Aug 16 01:12:53 EDT 2024 Thu Sep 26 15:47:16 EDT 2024 Sat Sep 28 08:27:01 EDT 2024 Fri Feb 23 02:29:51 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Pathogenicity Molecular determinants Influenza virus AH1N1pdm09 |
Language | English |
License | Copyright © 2019 Elsevier B.V. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c368t-d3efafd22f4218999d42432a8101b80fbf90a14de1744ea14398f89010f5e743 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 31445105 |
PQID | 2283105641 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | proquest_miscellaneous_2283105641 crossref_primary_10_1016_j_virusres_2019_197731 pubmed_primary_31445105 elsevier_sciencedirect_doi_10_1016_j_virusres_2019_197731 |
PublicationCentury | 2000 |
PublicationDate | 2019-10-15 |
PublicationDateYYYYMMDD | 2019-10-15 |
PublicationDate_xml | – month: 10 year: 2019 text: 2019-10-15 day: 15 |
PublicationDecade | 2010 |
PublicationPlace | Netherlands |
PublicationPlace_xml | – name: Netherlands |
PublicationTitle | Virus research |
PublicationTitleAlternate | Virus Res |
PublicationYear | 2019 |
Publisher | Elsevier B.V |
Publisher_xml | – name: Elsevier B.V |
References | de la Rosa-Zamboni, Vázquez-Pérez, Avila-Ríos, Carranco-Arenas, Ormsby, Cummings (bib0025) 2012; 7 Linderman, Chambers, Zost, Parkhouse, Li, Herrmann (bib0030) 2014; 111 Kochs, García-Sastre, Martínez-Sobrido (bib0070) 2007; 81 Hale, Steel, Medina, Manicassamy, Ye, Hickman (bib0080) 2010; 84 Rykkvin, Kilander, Dudman, Hungnes (bib0050) 2013; 18 Chambers, Skowronski, Sabaiduc, Winter, Dickinson, De Serres (bib0035) 2016; 21 Arriola, Garg, Anderson, Ryan, George, Zansky (bib0060) 2017; 65 Heaton, Sachs, Chen, Hai, Palese (bib0065) 2013; 110 Sevilla-Reyes, Chavaro-Pérez, Piten-Isidro, Gutiérrez-González, Santos-Mendoza (bib0085) 2013; 8 Wong, Kelly, C-MM, Shiu, Wu, Ni (bib0010) 2015; 182 Vazquez-Perez, Isa, Kobasa, Ormsby, Ramírez-Gonzalez, Romero-Rodríguez (bib0045) 2013; 10 Arellano-Llamas, Alfaro-Ruiz, Arriaga Canon, Imaz Rosshandler, Cruz-Lagunas, Zúñiga (bib0005) 2017; 12 Nemeroff, Barabino, Li, Keller, Krug (bib0075) 1998; 1 Goka, Vallely, Mutton, Klapper (bib0055) 2014; 159 Martínez-Briseño, Torre-Bouscoulet, Herrera-Zamora de, Díaz-Rico, Sandoval-Macías, Pérez-Padilla (bib0015) 2016; 68 WHO (bib0040) 2018 PAHO WHO (bib0020) 2015 Vazquez-Perez (10.1016/j.virusres.2019.197731_bib0045) 2013; 10 WHO (10.1016/j.virusres.2019.197731_bib0040) 2018 Arellano-Llamas (10.1016/j.virusres.2019.197731_bib0005) 2017; 12 Sevilla-Reyes (10.1016/j.virusres.2019.197731_bib0085) 2013; 8 Linderman (10.1016/j.virusres.2019.197731_bib0030) 2014; 111 Chambers (10.1016/j.virusres.2019.197731_bib0035) 2016; 21 Arriola (10.1016/j.virusres.2019.197731_bib0060) 2017; 65 Wong (10.1016/j.virusres.2019.197731_bib0010) 2015; 182 Hale (10.1016/j.virusres.2019.197731_bib0080) 2010; 84 PAHO WHO (10.1016/j.virusres.2019.197731_bib0020) 2015 Goka (10.1016/j.virusres.2019.197731_bib0055) 2014; 159 Nemeroff (10.1016/j.virusres.2019.197731_bib0075) 1998; 1 Rykkvin (10.1016/j.virusres.2019.197731_bib0050) 2013; 18 Heaton (10.1016/j.virusres.2019.197731_bib0065) 2013; 110 Martínez-Briseño (10.1016/j.virusres.2019.197731_bib0015) 2016; 68 Kochs (10.1016/j.virusres.2019.197731_bib0070) 2007; 81 de la Rosa-Zamboni (10.1016/j.virusres.2019.197731_bib0025) 2012; 7 |
References_xml | – volume: 18 year: 2013 ident: bib0050 article-title: Within-patient emergence of the influenza A(H1N1)pdm09 HA1 222G variant and clear association with severe disease, Norway publication-title: Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull contributor: fullname: Hungnes – volume: 21 start-page: 30168 year: 2016 ident: bib0035 article-title: Interim estimates of 2015/16 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, February 2016 publication-title: Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. contributor: fullname: De Serres – volume: 12 year: 2017 ident: bib0005 article-title: Molecular features of influenza A (H1N1)pdm09 prevalent in Mexico during winter seasons 2012-2014 publication-title: PLoS One contributor: fullname: Zúñiga – volume: 8 year: 2013 ident: bib0085 article-title: Protein clustering and RNA phylogenetic reconstruction of the influenza A [corrected] virus NS1 protein allow an update in classification and identification of motif conservation publication-title: PLoS One contributor: fullname: Santos-Mendoza – volume: 10 start-page: 41 year: 2013 ident: bib0045 article-title: A (H1N1) pdm09 HA D222 variants associated with severity and mortality in patients during a second wave in Mexico publication-title: Virol. J. contributor: fullname: Romero-Rodríguez – volume: 84 start-page: 6909 year: 2010 end-page: 6922 ident: bib0080 article-title: Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein publication-title: J. Virol. contributor: fullname: Hickman – volume: 7 year: 2012 ident: bib0025 article-title: Molecular characterization of the predominant influenza A(H1N1)pdm09 virus in Mexico, December 2011-February 2012 publication-title: PLoS One contributor: fullname: Cummings – volume: 1 start-page: 991 year: 1998 end-page: 1000 ident: bib0075 article-title: Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3′end formation of cellular pre-mRNAs publication-title: Mol. Cell contributor: fullname: Krug – volume: 159 start-page: 3167 year: 2014 end-page: 3183 ident: bib0055 article-title: Mutations associated with severity of the pandemic influenza A(H1N1)pdm09 in humans: a systematic review and meta-analysis of epidemiological evidence publication-title: Arch. Virol. contributor: fullname: Klapper – volume: 81 start-page: 7011 year: 2007 end-page: 7021 ident: bib0070 article-title: Multiple anti-interferon actions of the influenza A virus NS1 protein publication-title: J. Virol. contributor: fullname: Martínez-Sobrido – year: 2018 ident: bib0040 article-title: Recommended Composition of Influenza Virus Vaccines for Use in the 2017-2018 Northern Hemisphere Influenza Season [Internet] contributor: fullname: WHO – volume: 110 start-page: 20248 year: 2013 end-page: 20253 ident: bib0065 article-title: Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Palese – volume: 182 start-page: 294 year: 2015 end-page: 301 ident: bib0010 article-title: Hospitalization fatality risk of influenza a(H1N1)pdm09: a systematic review and meta-analysis publication-title: Am. J. Epidemiol. contributor: fullname: Ni – volume: 65 start-page: 1289 year: 2017 end-page: 1297 ident: bib0060 article-title: Influenza vaccination modifies disease severity among community-dwelling adults hospitalized with influenza publication-title: Clin Infect Dis Off Publ Infect Dis Soc Am. contributor: fullname: Zansky – volume: 68 start-page: 147 year: 2016 end-page: 153 ident: bib0015 article-title: Clinical characteristics and mortality of influenza a H1N1 and influenza-like illness in Mexico city in the 2013-2014 winter season publication-title: Rev Investig Clin Organo Hosp Enfermedades Nutr. contributor: fullname: Pérez-Padilla – volume: 111 start-page: 15798 year: 2014 end-page: 15803 ident: bib0030 article-title: Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season publication-title: Proc Natl Acad Sci U S A. contributor: fullname: Herrmann – year: 2015 ident: bib0020 article-title: Influenza Influenza Reports by Year [Internet] contributor: fullname: PAHO WHO – volume: 8 issue: 5 year: 2013 ident: 10.1016/j.virusres.2019.197731_bib0085 article-title: Protein clustering and RNA phylogenetic reconstruction of the influenza A [corrected] virus NS1 protein allow an update in classification and identification of motif conservation publication-title: PLoS One doi: 10.1371/journal.pone.0063098 contributor: fullname: Sevilla-Reyes – volume: 12 issue: 7 year: 2017 ident: 10.1016/j.virusres.2019.197731_bib0005 article-title: Molecular features of influenza A (H1N1)pdm09 prevalent in Mexico during winter seasons 2012-2014 publication-title: PLoS One doi: 10.1371/journal.pone.0180419 contributor: fullname: Arellano-Llamas – volume: 65 start-page: 1289 issue: 8 year: 2017 ident: 10.1016/j.virusres.2019.197731_bib0060 article-title: Influenza vaccination modifies disease severity among community-dwelling adults hospitalized with influenza publication-title: Clin Infect Dis Off Publ Infect Dis Soc Am. doi: 10.1093/cid/cix468 contributor: fullname: Arriola – volume: 21 start-page: 30168 issue: 11 year: 2016 ident: 10.1016/j.virusres.2019.197731_bib0035 article-title: Interim estimates of 2015/16 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, February 2016 publication-title: Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. contributor: fullname: Chambers – volume: 182 start-page: 294 issue: 4 year: 2015 ident: 10.1016/j.virusres.2019.197731_bib0010 article-title: Hospitalization fatality risk of influenza a(H1N1)pdm09: a systematic review and meta-analysis publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kwv054 contributor: fullname: Wong – year: 2015 ident: 10.1016/j.virusres.2019.197731_bib0020 contributor: fullname: PAHO WHO – volume: 111 start-page: 15798 issue: 44 year: 2014 ident: 10.1016/j.virusres.2019.197731_bib0030 article-title: Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season publication-title: Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1409171111 contributor: fullname: Linderman – year: 2018 ident: 10.1016/j.virusres.2019.197731_bib0040 contributor: fullname: WHO – volume: 81 start-page: 7011 issue: 13 year: 2007 ident: 10.1016/j.virusres.2019.197731_bib0070 article-title: Multiple anti-interferon actions of the influenza A virus NS1 protein publication-title: J. Virol. doi: 10.1128/JVI.02581-06 contributor: fullname: Kochs – volume: 110 start-page: 20248 issue: 50 year: 2013 ident: 10.1016/j.virusres.2019.197731_bib0065 article-title: Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1320524110 contributor: fullname: Heaton – volume: 68 start-page: 147 issue: 3 year: 2016 ident: 10.1016/j.virusres.2019.197731_bib0015 article-title: Clinical characteristics and mortality of influenza a H1N1 and influenza-like illness in Mexico city in the 2013-2014 winter season publication-title: Rev Investig Clin Organo Hosp Enfermedades Nutr. contributor: fullname: Martínez-Briseño – volume: 10 start-page: 41 year: 2013 ident: 10.1016/j.virusres.2019.197731_bib0045 article-title: A (H1N1) pdm09 HA D222 variants associated with severity and mortality in patients during a second wave in Mexico publication-title: Virol. J. doi: 10.1186/1743-422X-10-41 contributor: fullname: Vazquez-Perez – volume: 7 issue: 11 year: 2012 ident: 10.1016/j.virusres.2019.197731_bib0025 article-title: Molecular characterization of the predominant influenza A(H1N1)pdm09 virus in Mexico, December 2011-February 2012 publication-title: PLoS One doi: 10.1371/journal.pone.0050116 contributor: fullname: de la Rosa-Zamboni – volume: 18 issue: 3 year: 2013 ident: 10.1016/j.virusres.2019.197731_bib0050 article-title: Within-patient emergence of the influenza A(H1N1)pdm09 HA1 222G variant and clear association with severe disease, Norway publication-title: Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull contributor: fullname: Rykkvin – volume: 1 start-page: 991 issue: 7 year: 1998 ident: 10.1016/j.virusres.2019.197731_bib0075 article-title: Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3′end formation of cellular pre-mRNAs publication-title: Mol. Cell doi: 10.1016/S1097-2765(00)80099-4 contributor: fullname: Nemeroff – volume: 84 start-page: 6909 issue: 14 year: 2010 ident: 10.1016/j.virusres.2019.197731_bib0080 article-title: Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein publication-title: J. Virol. doi: 10.1128/JVI.00081-10 contributor: fullname: Hale – volume: 159 start-page: 3167 issue: 12 year: 2014 ident: 10.1016/j.virusres.2019.197731_bib0055 article-title: Mutations associated with severity of the pandemic influenza A(H1N1)pdm09 in humans: a systematic review and meta-analysis of epidemiological evidence publication-title: Arch. Virol. doi: 10.1007/s00705-014-2179-z contributor: fullname: Goka |
SSID | ssj0006376 |
Score | 2.342454 |
Snippet | •H1N1pdm09 belonging to clade 6B.1 instead of H3N2 were detected in Mexico in 2017.•A new glycosylation site in HA (S162 N) may affect the efficacy of the... Biennial H1N1pdm09 influenza A virus (IAV) epidemics have been associated with major severity of respiratory disease in Mexico. Atypically and in contrast with... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 197731 |
SubjectTerms | AH1N1pdm09 Influenza virus Molecular determinants Pathogenicity |
Title | Amino acid changes in HA and determinants of pathogenicity associated with influenza virus A H1N1pdm09 during the winter seasons 2015-2016 and 2016-2017 in Mexico |
URI | https://dx.doi.org/10.1016/j.virusres.2019.197731 https://www.ncbi.nlm.nih.gov/pubmed/31445105 https://search.proquest.com/docview/2283105641 |
Volume | 272 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1La9wwEB6SDYVeQt9NH2EKvXrXsh5rHU1ocFu6l6aQm5EtGRyIvSS7JckhPya_tDN-hPQQeujNskfWY0Yzn-XRDMDnVCotbcpe4iTBKomryKpqGRkTllpXXknXR_tcmfyX-naqT3fgaDoLw26Vo-4fdHqvrcc7i3E2F-umWfwksMLR5WjJSQ6MZndhj8yRUjPYy75-z1f3CtnIPscc00dc4cFB4bP57-ZiS8aII3cLOxcEh6R4zEY9hkF7W3T8DPZHEInZ0M_nsBPaF_BkSCt5_RLusvOm7dBVjcfhYO8lNi3mGbrWo3_gAINdjZyTuCMxaioC5OhGdgWPvEVL9fokJjcO-yFghrlYibU_jy0ORxyRICTRMoOQdxxJjJFGqWllCNO3yBdcWnIvfoQrEr5XcHL85eQoj8ZcDFElTbqJvAy1q32S1IpAAaFKrxIlE8fxwco0rsvaxk4oH-gLRwW6IgGoU_b9qHUglPIaZm3XhreA1tikLEmxyJLeFazlx04IWy59bFw4gMU0-cV6iLhRTK5oZ8XEroLZVQzsOgA78aj4S3YKMgv_rPtpYmpBC4v_lrg2dFsiSjgHmzaKaN4M3L7vjxQc1y3W7_6j5ffwlEtsB4X-ALPNxTZ8JICzKQ9hd34rDkcx_gP4Xfcx |
link.rule.ids | 315,786,790,4521,24144,27957,27958,45620,45714 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwELbooqq9VH1SWtpOpV7DxvEj8TFCoFBgL91K3CwndqQgkazobgX8HH5pZ_JA9IB66C2Jx_FjxjNfnPEMY98yIZUwGXmJowTLJK4iI6s00jqkSlVeCtdH-1zo4qf8fq7Ot9jBdBaG3CpH3T_o9F5bj0_m42zOV00z_4FghaLL4ZITFBjNPGHbUqVczth2fnxSLO4VshZ9jjmij6jCg4PCF_u_m6sNGiOK3M3NPkc4JPhjNuoxDNrboqOX7MUIIiEf-vmKbYX2NXs6pJW8ecPu8sum7cBVjYfhYO8vaFoocnCtB__AAQa6GigncYdi1FQIyMGN7AoeaIsW6_VJTG4d9EOAHAq-4Ct_GRsYjjgCQkikJQYB7TiiGAOOUuHK4LpvkS7oLqVenIVrFL63bHl0uDwoojEXQ1QJna0jL0Ltap8ktURQgKjSy0SKxFF8sDKL67I2sePSB_zCkQGvUADqjHw_ahUQpbxjs7Zrw3sGRpukLFGxiBLfFYyhYse5KVMfaxd22XyafLsaIm7YyRXtwk7sssQuO7Brl5mJR_Yv2bFoFv5Z9-vEVIsLi_6WuDZ0GyRKKAeb0hJpdgZu3_dHcIrrFqsP_9HyF_asWJ6d2tPjxclH9pxKyCZytcdm66tN-IRgZ11-HoX5D-2k-SM |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Amino+acid+changes+in+HA+and+determinants+of+pathogenicity+associated+with+influenza+virus+A+H1N1pdm09+during+the+winter+seasons+2015-2016+and+2016-2017+in+Mexico&rft.jtitle=Virus+research&rft.au=V%C3%A1zquez-P%C3%A9rez%2C+Joel+Armando&rft.au=De+La+Rosa-Zamboni%2C+Daniela&rft.au=Vega-S%C3%A1nchez%2C+%C3%81ngel+Emmanuel&rft.au=Guti%C3%A9rrez-Gonz%C3%A1lez%2C+Luis+Horacio&rft.date=2019-10-15&rft.pub=Elsevier+B.V&rft.issn=0168-1702&rft.eissn=1872-7492&rft.volume=272&rft_id=info:doi/10.1016%2Fj.virusres.2019.197731&rft.externalDocID=S0168170219301029 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0168-1702&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0168-1702&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0168-1702&client=summon |