miR-150-5p mediates extravillous trophoblast cell migration and angiogenesis functions by regulating VEGF and MMP9

• Published in: Placenta (Eastbourne) Vol. 93; pp. 94 - 100
• Main Authors: Zeng, Yu, Wei, Lijie, Lali, Mwamaka Sharifu, Chen, Yuting, Yu, Jun, Feng, Ling
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.04.2020
• Subjects: Adult; Cell Hypoxia - drug effects; Cell Hypoxia - genetics; Cell Line, Tumor; Cell Movement - drug effects; Cell Movement - genetics; Cobalt - pharmacology; Extravillous trophoblast; Female; Gene Expression Regulation - drug effects; Humans; Hypoxia; Infant, Newborn; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; MicroRNAs - antagonists & inhibitors; MicroRNAs - physiology; miR-150-5p; MMP9; Neovascularization, Physiologic - drug effects; Neovascularization, Physiologic - genetics; Preeclampsia; Pregnancy; Trophoblasts - drug effects; Trophoblasts - physiology; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; VEGF; Extravillous trophoblast; Hypoxia; miR-150-5p; MMP9; Preeclampsia; VEGF

miR-150-5p is involved in placenta function. Matrix metalloproteinases (MMPs) play important roles in migration and invasion of cells, while VEGF is the major contributing factor in angiogenesis, and they are related to miR-150-5p. However, the mechanism by which miR-150-5p regulates placental funct...