Inefficient Transmissibility of NS-Truncated H3N8 Equine Influenza Virus in Dogs

• Published in: Journal of microbiology and biotechnology Vol. 25; no. 3; pp. 317 - 320
• Main Authors: Song, Manki, Yeom, Minjoo, Park, Nanuri, Kang, Bokyu, Moon, Hyoungjoon, Jeong, Dae-Gwin, Kim, Jeong-Ki, Song, Daesub
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국미생물·생명공학회 01.03.2015
• Subjects: Animals; Antibodies, Viral - immunology; Disease Models, Animal; Dog Diseases - immunology; Dog Diseases - pathology; Dog Diseases - virology; Dogs; Horse Diseases - virology; Horses; Host Specificity; Influenza A Virus, H3N8 Subtype - genetics; Influenza A Virus, H3N8 Subtype - isolation & purification; Influenza A Virus, H3N8 Subtype - pathogenicity; Lung - pathology; Lung - ultrastructure; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - veterinary; Orthomyxoviridae Infections - virology; Viral Load - veterinary; Viral Nonstructural Proteins - genetics; 생물학
• ISSN: 1017-7825; 1738-8872
• DOI: 10.4014/jmb.1409.09078

H3N8 equine influenza virus (EIV) causes respiratory diseases in the horse population, and it has been demonstrated that EIV can transmit into dogs owing to its availability on receptors of canine respiratory epithelial cells. Recently, we isolated H3N8 EIV from an EIV-vaccinated horse that showed symptoms of respiratory disease, and which has a partially truncated nonstructural gene (NS). However, it is not clear that the NS-truncated EIV has an ability to cross the host species barrier from horses to dogs as well. Here, we experimentally infected the NS-truncated H3N8 EIV into dogs, and monitored their clinical signs and viral load in respiratory organs to determine the virus's transmissibility.