Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence

• Published in: The American journal of physiology Vol. 270; no. 1 Pt 1; p. G42
• Main Authors: Appleyard, C B, McCafferty, D M, Tigley, A W, Swain, M G, Wallace, J L
• Format: Journal Article
• Language: English
• Published: United States 01.01.1996
• Subjects: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Movement; Gastrointestinal Hemorrhage - chemically induced; Gastrointestinal Hemorrhage - pathology; Indomethacin; Leukocytes - physiology; Male; Naproxen; Rats; Rats, Wistar; Stomach - pathology; Stomach Diseases - chemically induced; Stomach Diseases - pathology; Stomach Diseases - physiopathology; Stomach Ulcer - chemically induced; Stomach Ulcer - pathology; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - physiology

Neutrophil adherence to the vascular endothelium has been suggested to be a critical event in the pathogenesis of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric damage. Recently, increased plasma levels of tumor necrosis factor-alpha (TNF-alpha), which can increase leukocyte adherence,...