A short de novo synthesis of nucleoside analogs

• Published in: Science (American Association for the Advancement of Science) Vol. 369; no. 6504; pp. 725 - 730
• Main Authors: Meanwell, Michael, Silverman, Steven M., Lehmann, Johannes, Adluri, Bharanishashank, Wang, Yang, Cohen, Ryan, Campeau, Louis-Charles, Britton, Robert
• Format: Journal Article
• Language: English
• Published: Washington The American Association for the Advancement of Science 07.08.2020
• Subjects: Aldehydes; Analogs; Carbohydrates; Catalysis; Chemical synthesis; Conformation; Deoxyribonucleic acid; DNA; DNA biosynthesis; Enantiomers; Fluorides; Fluorination; Nucleic acids; Nucleoside analogs; Nucleosides; Nucleotide analogs; Nucleotides; Proline; Purines; Pyrimidines; Replication; Ribose; Viruses

Nucleotide analogs are valuable tools and therapeutics because of their ability to interfere with processes such as DNA synthesis, which are vital to rapidly dividing cells and replicating viruses. These molecules are challenging to synthesize chemically. Meanwell et al. developed a “ribose last” sy...