Iron-catalyzed arene C−H hydroxylation

• Published in: Science (American Association for the Advancement of Science) Vol. 374; no. 6563; pp. 77 - 81
• Main Authors: Cheng, Lu, Wang, Huihui, Cai, Hengrui, Zhang, Jie, Gong, Xu, Han, Wei
• Format: Journal Article
• Language: English
• Published: Washington The American Association for the Advancement of Science 01.10.2021
• Subjects: Alcohols; Aldehydes; Aromatic compounds; Carbon; Catalysts; Functional groups; Hydrogen; Hydrogen bonding; Hydrogen bonds; Hydrogen peroxide; Hydroxyl groups; Hydroxylation; Iron; Ligands; Natural products; Oxidants; Oxidation; Oxidizing agents; Phenolic compounds; Phenols; Polyphenols; Regioselectivity; Selectivity; Substitution reactions; Substrates

Although iron-dependent enzymes efficiently hydroxylate aryl rings, this activity has proven hard to replicate with synthetic catalysts. Cheng et al . report that a disulfide ligand activates iron to catalyze carbon–hydrogen hydroxylation of a wide variety of arenes using hydrogen peroxide. The prot...