Dynamics of Human Palatal Wound Healing and the Associated Microbiome

• Published in: Journal of dental research Vol. 104; no. 1; pp. 97 - 105
• Main Authors: Yuan, H., Chlipala, G.E., Bangash, H.I., Meenakshi, R., Chen, D., Trivedi, H.M, DiPietro, L.A., Gajendrareddy, P., Chen, L.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2025; SAGE PUBLICATIONS, INC
• Subjects: Adult; Angiogenesis; Antimicrobial peptides; Cytokines - metabolism; Enzyme-Linked Immunosorbent Assay; Extracellular matrix; Female; Gene expression; Growth factors; Humans; Intercellular Signaling Peptides and Proteins - analysis; Male; Microbiomes; Microbiota; Mouth Mucosa - microbiology; Mucosa; Palate; Palate, Hard - microbiology; Real-Time Polymerase Chain Reaction; RNA, Ribosomal, 16S - analysis; rRNA 16S; Saliva; Saliva - microbiology; Wound healing; Wound Healing - physiology; microbiomes; wound mediator; oral wound model; regeneration; hard palate

Wound healing in the oral mucosa is superior to that in the skin, with faster wound closure accompanied by reduced inflammation, less angiogenesis, and minimal scar formation. A well-characterized oral wound model is critical to investigating the mechanisms of oral wound closure and the efficacy of...