Lindane-Induced Elimination of Gap Junctional Communication in Rat Uterine Myocytes Is Mediated by an Arachidonic Acid-Sensitive cAMP-Independent Mechanism

• Published in: Toxicology and applied pharmacology Vol. 135; no. 1; pp. 127 - 138
• Main Authors: Criswell, K.A., Lochcaruso, R.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.11.1995; Elsevier
• Subjects: Animals; Arachidonic Acid - physiology; Biological and medical sciences; Cell Communication - drug effects; Cyclic AMP - physiology; Female; Gap Junctions - drug effects; Hexachlorocyclohexane - toxicity; Hydrolysis - drug effects; Medical sciences; Muscle, Smooth - drug effects; Myometrium - drug effects; Myometrium - metabolism; Pesticides, fertilizers and other agrochemicals toxicology; Phosphatidylinositols - metabolism; Rats; Rats, Sprague-Dawley; Toxicology; Myometrium; Insecticide; Rat; Toxicity; Lindane; Rodentia; Pesticides; Cyclic AMP; Cell junction; Arachidonic acid; Striated muscle; In vitro; Gap junction; Myocyte; Vertebrata; Mammalia; Uterus; Organochlorine compounds; Animal

Previous studies by this laboratory showed that the pesticide lindane rapidly and potently inhibits gap junctional communication in myometrial smooth muscle cells. This study examined the possible role of cAMP or arachidonic acid in lindane′s elimination of myometrial gap junctional communication. L...