BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis

• Published in: Circulation (New York, N.Y.) Vol. 148; no. 22; pp. 1764 - 1777
• Main Authors: Yalcinkaya, Mustafa, Liu, Wenli, Thomas, Leigh-Anne, Olszewska, Malgorzata, Xiao, Tong, Abramowicz, Sandra, Papapetrou, Eirini P, Westerterp, Marit, Wang, Nan, Tabas, Ira, Tall, Alan R
• Format: Journal Article
• Language: English
• Published: United States 28.11.2023
• Subjects: Animals; Atherosclerosis - metabolism; Cardiovascular Diseases; Cholesterol - metabolism; Clonal Hematopoiesis; Deubiquitinating Enzymes; Dioxygenases; DNA-Binding Proteins - genetics; Humans; Hypercholesterolemia; Inflammasomes - metabolism; Mice; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; atherosclerosis; clonal hematopoiesis; inflammasomes; extracellular traps; neutrophils; phosphorylation; hypercholesterolemia

Clonal hematopoiesis (CH) has emerged as an independent risk factor for atherosclerotic cardiovascular disease, with activation of macrophage inflammasomes as a potential underlying mechanism. The NLRP3 (NLR family pyrin domain containing 3) inflammasome has a key role in promoting atherosclerosis i...