Leukotrienes Produced in Allergic Lung Inflammation Activate Alveolar Macrophages

• Published in: Cellular physiology and biochemistry Vol. 26; no. 3; pp. 319 - 326
• Main Authors: Silva, Reinaldo C., Landgraf, Maristella A., Hiyane, Meire I., Pacheco-Silva, Alvaro, Câmara, Niels O., Landgraf, Richardt G.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2010
• Subjects: Acetates - pharmacology; Allergens - pharmacology; Animals; Asthma - immunology; Cysteine - biosynthesis; Cysteine - chemistry; Cysteine - physiology; Disease Models, Animal; Klebsiella pneumoniae - immunology; Leukotriene Antagonists - pharmacology; Leukotriene C4 - metabolism; Leukotrienes - biosynthesis; Leukotrienes - chemistry; Leukotrienes - physiology; Lung - immunology; Lung - metabolism; Lung - pathology; Macrophages, Alveolar - drug effects; Macrophages, Alveolar - immunology; Male; Nitric Oxide - metabolism; Original Paper; Ovalbumin - pharmacology; Phagocytosis; Pneumonia - immunology; Pneumonia - metabolism; Pneumonia - pathology; Quinolines - pharmacology; Rats; Rats, Wistar; Receptors, IgG - metabolism; Receptors, IgG - physiology; Killing; Leukotrienes; Alveolar macrophages; Klebsiella pneumoniae; Asthma

It has been well-documented that leukotrienes (LTs) are released in allergic lung inflammation and that they participate in the physiopathology of asthma. A role for LTs in innate immunity has recently emerged: Cys-LTs were shown to enhance FcγR-mediated phagocytosis by alveolar macrophages (AMs). T...