Maternal Stress during Pregnancy in Mice Induces Sex-Dependent Behavioral Alterations in Offspring along with Impaired Serotonin and Kynurenine Pathways of Tryptophan Metabolism

• Published in: Developmental neuroscience Vol. 44; no. 6; p. 603
• Main Authors: Moura, Clarissa A, Cagni, Fernanda C, Costa, Layse R F, Tiago, Pamella R F, Croyal, Mikaël, Aguesse, Audrey, Reyes-Castro, Luis A, Zambrano, Elena, Bolaños-Jiménez, Francisco, Gavioli, Elaine Cristina
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2022
• Subjects: Animals; Anxiety - metabolism; Behavior, Animal; Female; Kynurenine - metabolism; Mice; Pregnancy; Serotonin - metabolism; Tryptophan - metabolism; Kynurenine; Mood disorders; Serotonin; Tryptophan metabolism; Prenatal stress

Maternal stress during pregnancy results in increased risk of developing psychiatric disorders in the offspring including anxiety, depression, schizophrenia, and autism. However, the mechanisms underlying this disease susceptibility remain largely to be determined. In this study, the involvement of...