Supramolecular inclusion complexation of simvastatin with methylated β-cyclodextrins for promoting osteogenic differentiation

• Published in: International journal of biological macromolecules Vol. 93; no. Pt B; pp. 1492 - 1498
• Main Authors: Terauchi, Masahiko, Inada, Takasuke, Tonegawa, Asato, Tamura, Atsushi, Yamaguchi, Satoshi, Harada, Kiyoshi, Yui, Nobuhiko
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2016
• Subjects: Alkaline Phosphatase - metabolism; Animals; beta-Cyclodextrins - chemistry; beta-Cyclodextrins - pharmacology; Bone regeneration; Cell Differentiation - drug effects; Cell Line; Drug Evaluation, Preclinical; Hydrophobic and Hydrophilic Interactions; Inclusion complex; Mice; Osteogenesis - drug effects; Osteogenetic differentiation; Simvastatin; Simvastatin - chemistry; Simvastatin - pharmacology; Solubility; β-cyclodextrin; Osteogenetic differentiation; Bone regeneration; β-cyclodextrin; Simvastatin; Inclusion complex

[Display omitted] Statins are recognized as a potential candidate to induce the regeneration of bone. However, statins are a strongly hydrophobic drug and it is difficult to administer at the local sites. In this study, the inclusion complexes of simvastatin (SV) with hydroxypropyl-β-cyclodextrin (H...