Are HLA-DR or TAP Genes Genetic Markers of Severity in Ulcerative Colitis?

• Published in: Journal of autoimmunity Vol. 9; no. 6; pp. 777 - 784
• Main Authors: Heresbach, Denis, Alizadeh, Mehdi, Reumaux, Dominique, Colombel, Jean-Frédéric, Delamaire, Maryvonne, Danze, Pierre-Marie, Gosselin, Michel, Genetet, Bernard, Bretagne, Jean-François, Semana, Gilbert
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01.12.1996; Elsevier
• Subjects: Adult; Alleles; Antibodies, Antineutrophil Cytoplasmic - blood; ATP-Binding Cassette Sub-Family B Member 2; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette, Sub-Family B, Member 3; Biological and medical sciences; Case-Control Studies; Colitis, Ulcerative - genetics; Colitis, Ulcerative - immunology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gene Frequency; Genetic Markers; Genotype; HLA class II genotypes; HLA-DR Antigens - genetics; HLA-DR2; Humans; Male; Medical sciences; Other diseases. Semiology; p-ANLA status; Prognosis; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; ulcerative colitis; HLA class II genotypes; p-ANLA status; ulcerative colitis; HLA-DR2; Human; HLA-System; Genetic inheritance; Antineutrophil cytoplasmic antibody; Genetic marker; HLA-DR-System; Class II histocompatibility antigen; Exploration; Genotype; Inflammatory disease; Digestive diseases; Intestinal disease; Genetics; Ulcerative colitis

The pathogeny of ulcerative colitis (UC) is not yet elucidated, but some arguments suggest the implication of genetic factors. Among the candidate genes, those encoding for HLA class II genotypes have been extensively studied in UC; however, discordant data may be imputable to heterogeneity, charact...