Repeated mild traumatic brain injury causes persistent changes in histone deacetylase function in hippocampus: Implications in learning and memory deficits in rats

• Published in: Brain research Vol. 1711; pp. 183 - 192
• Main Authors: Sagarkar, Sneha, Balasubramanian, Nagalakshmi, Mishra, Shruti, Choudhary, Amit G., Kokare, Dadasaheb M., Sakharkar, Amul J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.05.2019
• Subjects: Cocaine- and amphetamine-regulated transcript peptide; HDAC inhibitors; Hippocampus; Learning and memory; Mild traumatic brain injury; NOR; Learning and memory; MWM; TSA; DG; Mild traumatic brain injury; DI; rMTBI; Cocaine- and amphetamine-regulated transcript peptide; HDAC inhibitors; CARTp; Hippocampus

•Repeated mild traumatic brain injury (rMTBI) compromised learning and memory.•rMTBI persistently altered HDAC function in hippocampus.•rMTBI impaired histone acetylation at CART promoter and CART expression.•HDAC inhibitor restored rMTBI-induced deficits in histone acetylation.•The study implicates...