The role of TNF-α and TLR4 polymorphisms in the placenta of pregnant women complicated by preeclampsia and in silico analysis

• Published in: International journal of biological macromolecules Vol. 134; pp. 1205 - 1215
• Main Authors: Mohammadpour-Gharehbagh, Abbas, Jahantigh, Danial, Eskandari, Moein, Eskandari, Fatemeh, Rezaei, Mahnaz, Zeynali-Moghaddam, Shima, Teimoori, Batool, Salimi, Saeedeh
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2019
• Subjects: Adult; Alleles; Binding Sites; Computational Biology - methods; Cytokines - metabolism; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Inflammation Mediators - metabolism; Models, Molecular; Nucleic Acid Conformation; Odds Ratio; Placenta; Placenta - metabolism; Polymorphism; Polymorphism, Single Nucleotide; Pre-Eclampsia - genetics; Pre-Eclampsia - metabolism; Pre-Eclampsia - physiopathology; Preeclampsia; Pregnancy; Protein Binding; Structure-Activity Relationship; TLR4; TNF-α; Toll-Like Receptor 4 - chemistry; Toll-Like Receptor 4 - genetics; Tumor Necrosis Factor-alpha - chemistry; Tumor Necrosis Factor-alpha - genetics; Young Adult; Placenta; TNF-α; TLR4; Preeclampsia; Polymorphism

Evidence showed that, pro inflammatory cytokines and mediators of innate immune responses may involve in the pathogenesis of preeclampsia (PE). Therefore, the present investigation aimed to examine the possible effects of placental TNF-α and TLR4 polymorphisms on PE susceptibility. The placental tis...