Immunological aspects of nutritional diabetes prevention in NOD mice: A pilot study for the cow's milk-based IDDM prevention trial

• Published in: Diabetes (New York, N.Y.) Vol. 46; no. 4; pp. 557 - 564
• Main Authors: KARGES, W, HAMMOND-MCKIBBEN, D, CHEUNG, R. K, VISCONTI, M, SHIBUYA, N, KEMP, D, DOSCH, H.-M
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.04.1997
• Subjects: Adoptive Transfer; Analysis; Animals; Autoantigens - immunology; Biological and medical sciences; Care and treatment; Caseins - administration & dosage; Caseins - chemistry; Caseins - immunology; Cattle; Complications and side effects; Cross Reactions; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - prevention & control; Diabetes. Impaired glucose tolerance; Diet; Dietary protein; Disease Models, Animal; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Health aspects; Hydrolysis; Incidence; Insulin - analysis; Islets of Langerhans - pathology; Male; Medical sciences; Mice; Mice, Inbred NOD; Milk; Nutrition disorders; Nutritionally induced diseases; Ovalbumin - immunology; Pancreas - chemistry; Pilot Projects; Proteins in human nutrition; Serum Albumin - immunology; Spleen - cytology; Spleen - immunology; T-Lymphocytes - immunology; Time Factors; Type 1 diabetes; Endocrinopathy; Immunopathology; Insulitis; Rodentia; Autoimmune disease; Feeding; Antigen; Prevention; Milk protein; Vertebrata; Mammalia; Casein; Hydrolysate; Mouse; Risk factor; T-Lymphocyte; Insulin dependent diabetes; Endocrine pancreatic diseases

Human epidemiological studies delineated early exposure to intact dietary protein (e.g., most infant formulas) as an environmental risk factor for the development of IDDM. The Trial to Reduce IDDM in the Genetically at Risk (TRIGR), an international IDDM prevention trial, has been designed to determ...