Safety and efficacy of apixaban as thromboprophylaxis in myeloma patients receiving chemotherapy: A prospective cohort study

•We report an amended thromboprophylactic strategy using apixaban rather than low-molecular-weight heparin for high thrombotic risk myeloma patients.•No thrombotic events are reported in patients receiving prophylactic apixaban.•Major bleeding occurred in 1.2% patients on prophylactic apixaban.•Apix...

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Published inThrombosis research Vol. 213; pp. 27 - 29
Main Authors Sayar, Zara, Gates, Carolyn, Bristogiannis, Sotirios, Patel, Aisha, Ogunbiyi, Margaret Olabisi, Tailor, Anish, Yong, Kwee, Thomas, Mari
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.05.2022
Subjects
Anticoagulants - therapeutic use
Humans
Multiple Myeloma - complications
Multiple Myeloma - drug therapy
Prospective Studies
Pyrazoles
Pyridones - adverse effects
Venous Thromboembolism - drug therapy
Venous Thromboembolism - prevention & control
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Abstract •We report an amended thromboprophylactic strategy using apixaban rather than low-molecular-weight heparin for high thrombotic risk myeloma patients.•No thrombotic events are reported in patients receiving prophylactic apixaban.•Major bleeding occurred in 1.2% patients on prophylactic apixaban.•Apixaban appears to be an effective and safe alternative to low-molecular-weight-heparin as thromboprophylaxis in myeloma.
AbstractList •We report an amended thromboprophylactic strategy using apixaban rather than low-molecular-weight heparin for high thrombotic risk myeloma patients.•No thrombotic events are reported in patients receiving prophylactic apixaban.•Major bleeding occurred in 1.2% patients on prophylactic apixaban.•Apixaban appears to be an effective and safe alternative to low-molecular-weight-heparin as thromboprophylaxis in myeloma.
Author Gates, Carolyn
Ogunbiyi, Margaret Olabisi
Patel, Aisha
Tailor, Anish
Thomas, Mari
Sayar, Zara
Bristogiannis, Sotirios
Yong, Kwee
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CitedBy_id crossref_primary_10_1186_s13018_023_03942_y
crossref_primary_10_1182_hematology_2022000414
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Cites_doi 10.3324/haematol.2015.127126
10.1038/s41375-021-01141-4
10.1002/ajh.25459
10.1182/blood-2006-01-0154
10.1002/ajh.25603
10.6004/jnccn.2018.7273
10.1111/bjh.15392
10.1111/jth.13140
10.1038/sj.leu.2405062
10.1056/NEJMoa1814468
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References Pegourie, Karlin, Benboubker (bb0035) 2019; 94
Kastritis, Laina, Georgiopoulos (bb0050) 2021; 35
Li, Wu, Luo (bb0020) 2019; 17
Kaatz, Ahmad, Spyropoulos, Schulman (bb0040) 2015; 13
Noble, Matzdorff, Maraveyas, Holm, Pisa (bb0045) 2015; 100
Zonder, Barlogie, Durie, McCoy, Crowley, Hussein (bb0005) 2006; 108
Storrar, Mathur, Johnson, Roddie (bb0030) 2019; 185
Palumbo, Rajkumar, Dimopoulos (bb0010) 2008; 22
Sanfilippo, Luo, Wang (bb0015) 2019; 94
Carrier, Abou-Nassar, Mallick (bb0025) 2019; 380
Carrier (10.1016/j.thromres.2022.03.001_bb0025) 2019; 380
Noble (10.1016/j.thromres.2022.03.001_bb0045) 2015; 100
Kaatz (10.1016/j.thromres.2022.03.001_bb0040) 2015; 13
Storrar (10.1016/j.thromres.2022.03.001_bb0030) 2019; 185
Pegourie (10.1016/j.thromres.2022.03.001_bb0035) 2019; 94
Kastritis (10.1016/j.thromres.2022.03.001_bb0050) 2021; 35
Zonder (10.1016/j.thromres.2022.03.001_bb0005) 2006; 108
Sanfilippo (10.1016/j.thromres.2022.03.001_bb0015) 2019; 94
Palumbo (10.1016/j.thromres.2022.03.001_bb0010) 2008; 22
Li (10.1016/j.thromres.2022.03.001_bb0020) 2019; 17
References_xml – volume: 17
  start-page: 840
  year: 2019
  end-page: 847
  ident: bb0020
  article-title: Derivation and validation of a risk assessment model for immunomodulatory drug–associated thrombosis among patients with multiple myeloma
  publication-title: J. Natl. Compr. Cancer Netw.
  contributor:
    fullname: Luo
– volume: 13
  start-page: 2119
  year: 2015
  end-page: 2126
  ident: bb0040
  article-title: Subcommittee on control of anticoagulation. Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH
  publication-title: J. Thromb. Haemost.
  contributor:
    fullname: Schulman
– volume: 94
  start-page: 1176
  year: 2019
  end-page: 1184
  ident: bb0015
  article-title: Predicting venous thromboembolism in multiple myeloma: development and validation of the IMPEDE VTE score
  publication-title: Am. J. Hematol.
  contributor:
    fullname: Wang
– volume: 22
  start-page: 414
  year: 2008
  end-page: 423
  ident: bb0010
  article-title: Prevention of thalidomide-and lenalidomide-associated thrombosis in myeloma
  publication-title: Leukemia
  contributor:
    fullname: Dimopoulos
– volume: 185
  start-page: 142
  year: 2019
  end-page: 144
  ident: bb0030
  article-title: Safety and efficacy of apixaban for routine thromboprophylaxis in myeloma patients treated with thalidomide- and lenalidomide-containing regimens
  publication-title: Br. J. Haematol.
  contributor:
    fullname: Roddie
– volume: 35
  start-page: 1418
  year: 2021
  end-page: 1427
  ident: bb0050
  article-title: Carfilzomib-induced endothelial dysfunction, recovery of proteasome activity, and prediction of cardiovascular complications: a prospective study
  publication-title: Leukaemia.
  contributor:
    fullname: Georgiopoulos
– volume: 380
  start-page: 711
  year: 2019
  end-page: 719
  ident: bb0025
  article-title: Apixaban to prevent venous thromboembolism in patients with cancer
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Mallick
– volume: 94
  start-page: 635
  year: 2019
  end-page: 640
  ident: bb0035
  article-title: Apixaban for the prevention of thromboembolism in immunomodulatory-treated myeloma patients: myelaxat, a phase 2 pilot study
  publication-title: Am. J. Hematol.
  contributor:
    fullname: Benboubker
– volume: 100
  start-page: 1486
  year: 2015
  end-page: 1492
  ident: bb0045
  article-title: Assessing patients' anticoagulation preferences for the treatment of cancer-associated thrombosis using conjoint methodology
  publication-title: Haematologica
  contributor:
    fullname: Pisa
– volume: 108
  start-page: 403
  year: 2006
  ident: bb0005
  article-title: Thrombotic complications in patients with newly diagnosed multiple myeloma treated with lenalidomide and dexamethasone: benefit of aspirin prophylaxis
  publication-title: Blood
  contributor:
    fullname: Hussein
– volume: 100
  start-page: 1486
  year: 2015
  ident: 10.1016/j.thromres.2022.03.001_bb0045
  article-title: Assessing patients' anticoagulation preferences for the treatment of cancer-associated thrombosis using conjoint methodology
  publication-title: Haematologica
  doi: 10.3324/haematol.2015.127126
  contributor:
    fullname: Noble
– volume: 35
  start-page: 1418
  year: 2021
  ident: 10.1016/j.thromres.2022.03.001_bb0050
  article-title: Carfilzomib-induced endothelial dysfunction, recovery of proteasome activity, and prediction of cardiovascular complications: a prospective study
  publication-title: Leukaemia.
  doi: 10.1038/s41375-021-01141-4
  contributor:
    fullname: Kastritis
– volume: 94
  start-page: 635
  year: 2019
  ident: 10.1016/j.thromres.2022.03.001_bb0035
  article-title: Apixaban for the prevention of thromboembolism in immunomodulatory-treated myeloma patients: myelaxat, a phase 2 pilot study
  publication-title: Am. J. Hematol.
  doi: 10.1002/ajh.25459
  contributor:
    fullname: Pegourie
– volume: 108
  start-page: 403
  year: 2006
  ident: 10.1016/j.thromres.2022.03.001_bb0005
  article-title: Thrombotic complications in patients with newly diagnosed multiple myeloma treated with lenalidomide and dexamethasone: benefit of aspirin prophylaxis
  publication-title: Blood
  doi: 10.1182/blood-2006-01-0154
  contributor:
    fullname: Zonder
– volume: 94
  start-page: 1176
  year: 2019
  ident: 10.1016/j.thromres.2022.03.001_bb0015
  article-title: Predicting venous thromboembolism in multiple myeloma: development and validation of the IMPEDE VTE score
  publication-title: Am. J. Hematol.
  doi: 10.1002/ajh.25603
  contributor:
    fullname: Sanfilippo
– volume: 17
  start-page: 840
  year: 2019
  ident: 10.1016/j.thromres.2022.03.001_bb0020
  article-title: Derivation and validation of a risk assessment model for immunomodulatory drug–associated thrombosis among patients with multiple myeloma
  publication-title: J. Natl. Compr. Cancer Netw.
  doi: 10.6004/jnccn.2018.7273
  contributor:
    fullname: Li
– volume: 185
  start-page: 142
  issue: 1
  year: 2019
  ident: 10.1016/j.thromres.2022.03.001_bb0030
  article-title: Safety and efficacy of apixaban for routine thromboprophylaxis in myeloma patients treated with thalidomide- and lenalidomide-containing regimens
  publication-title: Br. J. Haematol.
  doi: 10.1111/bjh.15392
  contributor:
    fullname: Storrar
– volume: 13
  start-page: 2119
  year: 2015
  ident: 10.1016/j.thromres.2022.03.001_bb0040
  article-title: Subcommittee on control of anticoagulation. Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/jth.13140
  contributor:
    fullname: Kaatz
– volume: 22
  start-page: 414
  year: 2008
  ident: 10.1016/j.thromres.2022.03.001_bb0010
  article-title: Prevention of thalidomide-and lenalidomide-associated thrombosis in myeloma
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2405062
  contributor:
    fullname: Palumbo
– volume: 380
  start-page: 711
  issue: 8
  year: 2019
  ident: 10.1016/j.thromres.2022.03.001_bb0025
  article-title: Apixaban to prevent venous thromboembolism in patients with cancer
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1814468
  contributor:
    fullname: Carrier
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Snippet •We report an amended thromboprophylactic strategy using apixaban rather than low-molecular-weight heparin for high thrombotic risk myeloma patients.•No...
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SubjectTerms Anticoagulants - therapeutic use
Humans
Multiple Myeloma - complications
Multiple Myeloma - drug therapy
Prospective Studies
Pyrazoles
Pyridones - adverse effects
Venous Thromboembolism - drug therapy
Venous Thromboembolism - prevention & control
Title Safety and efficacy of apixaban as thromboprophylaxis in myeloma patients receiving chemotherapy: A prospective cohort study
URI https://dx.doi.org/10.1016/j.thromres.2022.03.001
https://www.ncbi.nlm.nih.gov/pubmed/35278887
https://search.proquest.com/docview/2638725313
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