Redox Switches Controlling Nitric Oxide Signaling in the Resistance Vasculature and Implications for Blood Pressure Regulation: Mid-Career Award for Research Excellence 2020
The arterial resistance vasculature modulates blood pressure and flow to match oxygen delivery to tissue metabolic demand. As such, resistance arteries and arterioles have evolved a series of highly orchestrated cell-cell communication mechanisms between endothelial cells and vascular smooth muscle...
Saved in:
| Published in | Hypertension (Dallas, Tex. 1979) Vol. 78; no. 4; pp. 912 - 926 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.10.2021
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The arterial resistance vasculature modulates blood pressure and flow to match oxygen delivery to tissue metabolic demand. As such, resistance arteries and arterioles have evolved a series of highly orchestrated cell-cell communication mechanisms between endothelial cells and vascular smooth muscle cells to regulate vascular tone. In response to neurohormonal agonists, release of several intracellular molecules, including nitric oxide, evokes changes in vascular tone. We and others have uncovered novel redox switches in the walls of resistance arteries that govern nitric oxide compartmentalization and diffusion. In this review, we discuss our current understanding of redox switches controlling nitric oxide signaling in endothelial and vascular smooth muscle cells, focusing on new mechanistic insights, physiological and pathophysiological implications, and advances in therapeutic strategies for hypertension and other diseases. |
|---|---|
| AbstractList | The arterial resistance vasculature modulates blood pressure and flow to match oxygen delivery to tissue metabolic demand. As such, resistance arteries and arterioles have evolved a series of highly orchestrated cell-cell communication mechanisms between endothelial cells and vascular smooth muscle cells to regulate vascular tone. In response to neurohormonal agonists, release of several intracellular molecules, including nitric oxide, evokes changes in vascular tone. We and others have uncovered novel redox switches in the walls of resistance arteries that govern nitric oxide compartmentalization and diffusion. In this review, we discuss our current understanding of redox switches controlling nitric oxide signaling in endothelial and vascular smooth muscle cells, focusing on new mechanistic insights, physiological and pathophysiological implications, and advances in therapeutic strategies for hypertension and other diseases. |
| Author | Wood, Katherine C Straub, Adam C Yuan, Shuai Schmidt, Heidi M Galley, Joseph C Aramide Modupe Dosunmu-Ogunbi, Atinuke |
| Author_xml | – sequence: 1 givenname: Atinuke surname: Aramide Modupe Dosunmu-Ogunbi fullname: Aramide Modupe Dosunmu-Ogunbi, Atinuke organization: Department of Pharmacology and Chemical Biology (A.A.M.D.-O., J.C.G., H.M.S., A.C.S), University of Pittsburgh, PA – sequence: 2 givenname: Joseph C surname: Galley fullname: Galley, Joseph C organization: Department of Pharmacology and Chemical Biology (A.A.M.D.-O., J.C.G., H.M.S., A.C.S), University of Pittsburgh, PA – sequence: 3 givenname: Shuai orcidid: 0000-0002-9590-6555 surname: Yuan fullname: Yuan, Shuai organization: Heart, Lung, Blood and Vascular Medicine Institute (A.A.M.D.-O., J.C.G., S.Y., H.M.S., K.C.W., A.C.S.), University of Pittsburgh, PA – sequence: 4 givenname: Heidi M orcidid: 0000-0002-3084-9094 surname: Schmidt fullname: Schmidt, Heidi M organization: Department of Pharmacology and Chemical Biology (A.A.M.D.-O., J.C.G., H.M.S., A.C.S), University of Pittsburgh, PA – sequence: 5 givenname: Katherine C surname: Wood fullname: Wood, Katherine C organization: Heart, Lung, Blood and Vascular Medicine Institute (A.A.M.D.-O., J.C.G., S.Y., H.M.S., K.C.W., A.C.S.), University of Pittsburgh, PA – sequence: 6 givenname: Adam C orcidid: 0000-0003-0542-9466 surname: Straub fullname: Straub, Adam C organization: Center for Microvascular Research (A.C.S.), University of Pittsburgh, PA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34420371$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkc1uEzEQgK2qqE1bXgGZG5cN_lvvmluIAolUkippEZxWrj2bGG3sYO-q4aF4R3bTwoHTSDPf_Gi-K3TugweE3lIyplTS9_Pvd7P1_Wy5WayWk_lkTBkdUykUP0MjmjORiVzyczQiVIlMUfrtEl2l9IMQKoQoLtAlF4IRXtAR-r0GG4548-Ras4OEp8G3MTSN81u8dG10Bq-OzgLeuK3Xp7TzuN0BXkNyqdXeAP6qk-ka3XYRsPYWL_aHxhnduuATrkPEH5sQLL6LkNLArGE74H35A_7ibDbVESDiyZOO9sT3s0FHs8Ozo4GmgWEJI4zcoFe1bhK8fonX6OHT7H46z25XnxfTyW1muCzbrCw5CK1qDYJLzRQvH3UhpZASiFIUSkU44ZJCXfKS57qUBa9ZIS0pmM0L4Nfo3fPcQww_O0httXdpuER7CF2qWP9fqQoh8h5Vz6iJIaUIdXWIbq_jr4qSarBV_Wer6m1VJ1t975uXNd3jHuy_zr96-B-fPZWy |
| CitedBy_id | crossref_primary_10_1016_j_niox_2022_01_006 crossref_primary_10_1016_j_ejphar_2023_175596 crossref_primary_10_1161_HYPERTENSIONAHA_122_19862 crossref_primary_10_1016_j_redox_2022_102425 crossref_primary_10_3389_fcvm_2022_837270 crossref_primary_10_1016_j_niox_2023_12_003 |
| Cites_doi | 10.1161/CIRCRESAHA.121.318082 10.1161/CIRCRESAHA.117.310705 10.1097/FJC.0000000000000771 10.1186/1471-2210-1-13 10.1161/CIRCRESAHA.118.313926 10.1080/07315724.1990.10720407 10.1038/nrd2466 10.1016/j.freeradbiomed.2019.06.028 10.1161/HYPERTENSIONAHA.117.10787 10.1038/sj.jhh.1001945 10.1002/14651858.CD007435.pub3 10.1126/science.1216283 10.1016/S0021-9258(19)69708-5 10.1016/j.jprot.2016.02.009 10.1161/01.RES.0000173461.36221.2e 10.1016/j.vph.2017.05.003 10.1016/j.freeradbiomed.2011.04.005 10.1111/j.1476-5381.1989.tb11833.x 10.1172/JCI123462 10.1073/pnas.85.22.8664 10.1007/s00424-012-1167-y 10.1016/j.redox.2017.09.009 10.1111/joim.12441 10.2174/1389201017666151223123904 10.1159/000092518 10.1161/CIRCRESAHA.109.207381 10.1165/rcmb.2016-0418OC 10.1016/j.niox.2018.03.016 10.1161/hypertensionaha.111.00933 10.1016/j.freeradbiomed.2018.03.006 10.1016/j.bcp.2017.11.010 10.1038/nm.2603 10.1038/nature11626 10.1007/s00395-014-0456-3 10.1161/CIR.0000000000000659 10.1161/HYPERTENSIONAHA.109.130351 10.1016/0005-2744(78)90121-3 10.1073/pnas.0605907103 10.1161/HYPERTENSIONAHA.118.12005 10.1089/ars.2015.6254 10.1161/JAHA.117.007157 10.1152/ajpheart.1991.260.1.H242 10.1007/s00210-011-0712-0 10.1056/NEJMoa1915928 10.1161/01.res.61.6.866 10.1073/pnas.84.18.6340 10.1074/jbc.M109.064873 10.1016/j.freeradbiomed.2020.11.001 10.1016/j.bcp.2013.03.023 10.1172/JCI116907 10.3892/ijmm.2013.1459 10.3109/10715762.2015.1089987 10.2174/0929867323666160428110059 10.1074/jbc.M501527200 10.1152/japplphysiol.00513.2006 10.1172/JCI28371 10.1152/ajpregu.00124.2004 10.1016/S0021-9258(18)55297-2 10.2174/1389450119666180816120816 10.1172/jci.insight.129183 10.1073/pnas.79.9.2870 10.1111/apha.12649 10.1161/CIRCRESAHA.111.259242 10.1161/hypertensionaha.116.08171 10.1016/j.vph.2019.03.004 10.1016/j.freeradbiomed.2018.11.002 10.1161/ATVBAHA.114.303974 10.1146/annurev-physiol-020518-114417 10.1161/01.hyp.28.4.569 10.1152/ajplung.00119.2005 10.1073/pnas.0609778104 10.1089/ars.2012.4599 10.1126/science.1144318 10.1073/pnas.91.7.2592 10.1016/j.redox.2018.101072 10.1007/112_0603 10.1097/FJC.0b013e31822d80a5 10.1161/01.hyp.13.6.859 10.1007/BF02535072 10.1021/acs.biochem.5b00572 10.1161/HYPERTENSIONAHA.110.159301 10.1093/cvr/cvt341 10.1152/physrev.00046.2003 10.1038/sj.jhh.1002138 10.1016/0022-2836(75)90382-4 10.1016/j.redox.2015.06.009 10.1152/ajpheart.00089.2013 10.1074/jbc.M603357200 10.1080/10739680902744404 10.1152/physiol.00042.2013 10.1016/j.febslet.2007.12.025 10.1093/cvr/cvr110 10.1073/pnas.88.22.10045 10.1152/ajplung.00062.2009 10.1074/jbc.M117.787390 10.1038/288373a0 10.1093/cvr/cvt147 10.1165/rcmb.2017-0292OC 10.1111/j.1471-4159.1990.tb01889.x 10.1152/ajpheart.01025.2002 10.1016/j.vph.2017.11.003 10.1038/nrdp.2018.14 10.1074/jbc.M114.559393 10.1038/sj.bjp.0700982 10.1161/01.hyp.16.2.162 10.1097/HJH.0000000000000422 10.1016/s0022-5320(67)80239-9 10.1161/ATVBAHA.110.215939 10.1016/0090-6980(76)90125-8 10.1111/apha.13080 10.1016/j.yjmcc.2019.06.012 10.1006/abbi.1997.0408 10.1038/24388 10.1056/NEJMoa1209655 10.1152/ajpheart.51.2008 10.1182/bloodadvances.2019000527 10.1139/o92-065 10.1016/j.freeradbiomed.2009.10.046 10.1016/j.niox.2018.03.012 10.1186/1472-6807-10-2 10.1073/pnas.0511118103 10.1016/j.redox.2016.04.001 10.1001/jama.1949.02900400005002 10.1006/bbrc.1999.1444 10.1074/jbc.M114.629964 10.1152/ajpheart.1986.250.5.H822 10.1080/14728222.2017.1310840 10.1161/CIRCULATIONAHA.109.890962 10.1073/pnas.0703944104 10.1038/sj.bjp.0704483 10.1097/00004872-199816030-00006 10.1161/CIRCRESAHA.117.310933 10.1161/CIRCULATIONAHA.119.043385 10.3389/fphys.2018.00258 10.1172/JCI87425 10.1016/s0162-0134(00)80291-3 10.1016/j.freeradbiomed.2009.05.018 10.1159/000371491 10.1073/pnas.89.1.444 10.1093/cvr/cvn182 10.1161/01.hyp.34.4.539 10.1161/01.HYP.0000235682.47673.ab 10.1016/j.redox.2018.11.008 10.1021/bi960442g 10.1056/NEJMoa1209657 10.1111/j.1751-7176.2012.00669.x 10.1038/377239a0 10.1111/j.1432-1033.1991.tb16509.x 10.1016/j.bbalip.2016.04.014 10.1164/rccm.200707-1121OC 10.1073/pnas.1205854109 10.1161/01.res.78.3.415 10.1161/CIR.0000000000000597 10.1016/j.freeradbiomed.2021.03.011 10.1021/bi301657w 10.1016/S0021-9258(19)49528-8 10.1007/s11906-013-0377-9 10.1016/j.freeradbiomed.2017.02.049 10.1073/pnas.84.24.9265 10.1111/cts.12672 10.1016/j.ijms.2010.07.021 10.1038/sj.bjp.0704778 10.1126/science.286.5444.1583 10.1007/s11255-015-1071-4 10.1016/j.niox.2018.05.002 10.1152/ajpregu.90843.2008 10.1177/1358863X17722211 10.1006/bbrc.1997.6878 10.1161/01.hyp.23.2.229 10.1073/pnas.94.12.6529 10.1093/eurheartj/ehu436 10.1038/s41598-020-66310-4 10.1172/JCI80275 10.1124/pr.112.007351 10.1172/JCI99933 10.1074/jbc.M411545200 10.1083/jcb.3.3.457 10.1073/pnas.2023130118 10.1097/FJC.0000000000000173 10.1242/jcs.037481 10.1152/ajpheart.00614.2009 10.1161/HYPERTENSIONAHA.113.01445 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1161/HYPERTENSIONAHA.121.16493 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1524-4563 |
| EndPage | 926 |
| ExternalDocumentID | 10_1161_HYPERTENSIONAHA_121_16493 34420371 |
| Genre | Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: F31 HL149241 – fundername: NHLBI NIH HHS grantid: F31 HL151173 – fundername: NHLBI NIH HHS grantid: R01 HL149825 – fundername: NHLBI NIH HHS grantid: R01 HL133864 – fundername: NHLBI NIH HHS grantid: R01 HL153532 – fundername: NHLBI NIH HHS grantid: R01 HL128304 |
| GroupedDBID | --- .-D .3C .55 .GJ .XZ .Z2 01R 0R~ 18M 1J1 2WC 3O- 40H 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 71W 77Y 7O~ AAAAV AAAXR AAFWJ AAGIX AAHPQ AAIQE AAJCS AAMOA AAMTA AAQKA AARTV AASCR AASOK AAXQO AAYEP ABASU ABBUW ABDIG ABJNI ABOCM ABQRW ABVCZ ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFO ACGFS ACILI ACLDA ACWDW ACWRI ACXJB ACXNZ ADBBV ADFPA ADGGA ADHPY ADNKB AE3 AE6 AEBDS AEETU AENEX AFDTB AFEXH AFFNX AFUWQ AGINI AHMBA AHOMT AHQNM AHRYX AHVBC AIJEX AINUH AJIOK AJNWD AJNYG AJZMW AKULP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BAWUL BCGUY BOYCO BQLVK BS7 C1A C45 CGR CS3 CUY CVF DIK DIWNM DUNZO E.X E3Z EBS ECM EEVPB EIF EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG FL- FW0 GNXGY GQDEL GX1 H0~ H13 HLJTE HZ~ IKREB IKYAY IN~ IPNFZ JF9 JG8 JK3 JK8 K-A K-F K8S KD2 KMI KQ8 L-C L7B N4W N9A NPM N~7 N~B N~M O9- OAG OAH OB3 OCUKA ODA ODMTH OGROG OHYEH OK1 OL1 OLG OLH OLU OLV OLW OLY OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OWBYB OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P PQQKQ R58 RAH RHF RIG RLZ S4R S4S T8P TEORI TR2 TSPGW V2I VVN W3M W8F WH7 WOQ WOW X3V X3W X7M XXN XYM YFH YHZ YOC YYM YYP ZFV ZGI ZZMQN AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c368t-883e4a9fae436a2938ba766466e0991e89030361ef83835a8673f276d072d57e3 |
| ISSN | 0194-911X |
| IngestDate | Fri Oct 25 01:51:08 EDT 2024 Fri Aug 23 00:39:30 EDT 2024 Wed Oct 16 00:42:38 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c368t-883e4a9fae436a2938ba766466e0991e89030361ef83835a8673f276d072d57e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 |
| ORCID | 0000-0002-9590-6555 0000-0003-0542-9466 0000-0002-3084-9094 |
| OpenAccessLink | https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.121.16493 |
| PMID | 34420371 |
| PQID | 2563697445 |
| PQPubID | 23479 |
| PageCount | 15 |
| ParticipantIDs | proquest_miscellaneous_2563697445 crossref_primary_10_1161_HYPERTENSIONAHA_121_16493 pubmed_primary_34420371 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-10-01 |
| PublicationDateYYYYMMDD | 2021-10-01 |
| PublicationDate_xml | – month: 10 year: 2021 text: 2021-10-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Hypertension (Dallas, Tex. 1979) |
| PublicationTitleAlternate | Hypertension |
| PublicationYear | 2021 |
| References | e_1_3_4_3_2 e_1_3_4_152_2 e_1_3_4_175_2 e_1_3_4_110_2 e_1_3_4_133_2 e_1_3_4_156_2 e_1_3_4_179_2 e_1_3_4_114_2 e_1_3_4_137_2 e_1_3_4_61_2 e_1_3_4_84_2 e_1_3_4_7_2 e_1_3_4_118_2 e_1_3_4_80_2 e_1_3_4_23_2 e_1_3_4_69_2 e_1_3_4_42_2 e_1_3_4_27_2 e_1_3_4_46_2 e_1_3_4_88_2 e_1_3_4_182_2 e_1_3_4_163_2 e_1_3_4_140_2 e_1_3_4_121_2 e_1_3_4_167_2 e_1_3_4_102_2 e_1_3_4_144_2 Murad F (e_1_3_4_11_2) 1978; 9 e_1_3_4_72_2 e_1_3_4_125_2 e_1_3_4_95_2 e_1_3_4_106_2 e_1_3_4_148_2 e_1_3_4_30_2 e_1_3_4_129_2 e_1_3_4_91_2 Uematsu T (e_1_3_4_113_2) 1994; 32 e_1_3_4_34_2 e_1_3_4_57_2 e_1_3_4_53_2 e_1_3_4_15_2 e_1_3_4_38_2 e_1_3_4_76_2 e_1_3_4_99_2 e_1_3_4_19_2 e_1_3_4_170_2 e_1_3_4_2_2 e_1_3_4_174_2 Park SY (e_1_3_4_186_2) 2018 e_1_3_4_151_2 e_1_3_4_132_2 e_1_3_4_178_2 e_1_3_4_155_2 e_1_3_4_136_2 e_1_3_4_62_2 e_1_3_4_85_2 e_1_3_4_117_2 e_1_3_4_159_2 e_1_3_4_6_2 e_1_3_4_81_2 e_1_3_4_20_2 e_1_3_4_43_2 e_1_3_4_24_2 e_1_3_4_47_2 e_1_3_4_66_2 e_1_3_4_89_2 e_1_3_4_28_2 e_1_3_4_181_2 e_1_3_4_120_2 e_1_3_4_162_2 e_1_3_4_189_2 e_1_3_4_101_2 e_1_3_4_124_2 e_1_3_4_143_2 e_1_3_4_166_2 e_1_3_4_185_2 e_1_3_4_73_2 e_1_3_4_96_2 e_1_3_4_105_2 e_1_3_4_128_2 e_1_3_4_147_2 Romanowski A (e_1_3_4_126_2) 1960; 35 e_1_3_4_50_2 e_1_3_4_92_2 e_1_3_4_109_2 e_1_3_4_12_2 e_1_3_4_58_2 e_1_3_4_54_2 e_1_3_4_31_2 e_1_3_4_16_2 e_1_3_4_77_2 e_1_3_4_35_2 e_1_3_4_39_2 Schrammel A (e_1_3_4_65_2) 1996; 50 e_1_3_4_131_2 e_1_3_4_150_2 e_1_3_4_173_2 e_1_3_4_112_2 e_1_3_4_135_2 e_1_3_4_154_2 e_1_3_4_177_2 e_1_3_4_82_2 e_1_3_4_9_2 e_1_3_4_116_2 e_1_3_4_139_2 e_1_3_4_158_2 e_1_3_4_63_2 e_1_3_4_40_2 e_1_3_4_5_2 e_1_3_4_44_2 e_1_3_4_21_2 e_1_3_4_48_2 e_1_3_4_86_2 e_1_3_4_25_2 e_1_3_4_67_2 e_1_3_4_180_2 e_1_3_4_29_2 e_1_3_4_142_2 e_1_3_4_161_2 e_1_3_4_100_2 e_1_3_4_146_2 e_1_3_4_184_2 e_1_3_4_123_2 e_1_3_4_165_2 e_1_3_4_93_2 e_1_3_4_104_2 e_1_3_4_74_2 e_1_3_4_127_2 e_1_3_4_169_2 e_1_3_4_51_2 e_1_3_4_108_2 e_1_3_4_70_2 e_1_3_4_55_2 e_1_3_4_32_2 e_1_3_4_59_2 e_1_3_4_97_2 e_1_3_4_13_2 e_1_3_4_36_2 e_1_3_4_78_2 e_1_3_4_17_2 e_1_3_4_153_2 e_1_3_4_130_2 e_1_3_4_172_2 e_1_3_4_111_2 e_1_3_4_157_2 e_1_3_4_134_2 e_1_3_4_176_2 e_1_3_4_60_2 e_1_3_4_83_2 e_1_3_4_115_2 e_1_3_4_8_2 e_1_3_4_138_2 e_1_3_4_41_2 e_1_3_4_119_2 e_1_3_4_4_2 e_1_3_4_22_2 e_1_3_4_45_2 e_1_3_4_68_2 e_1_3_4_26_2 e_1_3_4_49_2 e_1_3_4_64_2 e_1_3_4_87_2 e_1_3_4_160_2 Yamagami T (e_1_3_4_188_2) 1975; 11 e_1_3_4_141_2 e_1_3_4_164_2 e_1_3_4_187_2 e_1_3_4_122_2 e_1_3_4_145_2 e_1_3_4_168_2 e_1_3_4_183_2 e_1_3_4_71_2 e_1_3_4_94_2 e_1_3_4_103_2 e_1_3_4_149_2 e_1_3_4_52_2 e_1_3_4_90_2 e_1_3_4_107_2 e_1_3_4_79_2 e_1_3_4_33_2 e_1_3_4_10_2 e_1_3_4_75_2 e_1_3_4_98_2 e_1_3_4_37_2 e_1_3_4_14_2 e_1_3_4_56_2 e_1_3_4_18_2 e_1_3_4_171_2 |
| References_xml | – ident: e_1_3_4_4_2 doi: 10.1161/CIRCRESAHA.121.318082 – ident: e_1_3_4_70_2 doi: 10.1161/CIRCRESAHA.117.310705 – ident: e_1_3_4_132_2 doi: 10.1097/FJC.0000000000000771 – ident: e_1_3_4_171_2 doi: 10.1186/1471-2210-1-13 – ident: e_1_3_4_50_2 doi: 10.1161/CIRCRESAHA.118.313926 – ident: e_1_3_4_137_2 doi: 10.1080/07315724.1990.10720407 – ident: e_1_3_4_136_2 doi: 10.1038/nrd2466 – ident: e_1_3_4_147_2 doi: 10.1016/j.freeradbiomed.2019.06.028 – ident: e_1_3_4_187_2 doi: 10.1161/HYPERTENSIONAHA.117.10787 – ident: e_1_3_4_129_2 doi: 10.1038/sj.jhh.1001945 – ident: e_1_3_4_183_2 doi: 10.1002/14651858.CD007435.pub3 – ident: e_1_3_4_49_2 doi: 10.1126/science.1216283 – ident: e_1_3_4_79_2 doi: 10.1016/S0021-9258(19)69708-5 – ident: e_1_3_4_84_2 doi: 10.1016/j.jprot.2016.02.009 – ident: e_1_3_4_23_2 doi: 10.1161/01.RES.0000173461.36221.2e – ident: e_1_3_4_142_2 doi: 10.1016/j.vph.2017.05.003 – ident: e_1_3_4_146_2 doi: 10.1016/j.freeradbiomed.2011.04.005 – ident: e_1_3_4_40_2 doi: 10.1111/j.1476-5381.1989.tb11833.x – ident: e_1_3_4_166_2 doi: 10.1172/JCI123462 – ident: e_1_3_4_9_2 doi: 10.1073/pnas.85.22.8664 – ident: e_1_3_4_140_2 doi: 10.1007/s00424-012-1167-y – ident: e_1_3_4_16_2 doi: 10.1016/j.redox.2017.09.009 – ident: e_1_3_4_134_2 doi: 10.1111/joim.12441 – ident: e_1_3_4_163_2 doi: 10.2174/1389201017666151223123904 – ident: e_1_3_4_174_2 doi: 10.1159/000092518 – ident: e_1_3_4_15_2 doi: 10.1161/CIRCRESAHA.109.207381 – ident: e_1_3_4_39_2 doi: 10.1165/rcmb.2016-0418OC – ident: e_1_3_4_158_2 doi: 10.1016/j.niox.2018.03.016 – ident: e_1_3_4_149_2 doi: 10.1161/hypertensionaha.111.00933 – ident: e_1_3_4_138_2 doi: 10.1016/j.freeradbiomed.2018.03.006 – ident: e_1_3_4_179_2 doi: 10.1016/j.bcp.2017.11.010 – ident: e_1_3_4_91_2 doi: 10.1038/nm.2603 – ident: e_1_3_4_30_2 doi: 10.1038/nature11626 – ident: e_1_3_4_75_2 doi: 10.1007/s00395-014-0456-3 – ident: e_1_3_4_2_2 doi: 10.1161/CIR.0000000000000659 – ident: e_1_3_4_184_2 doi: 10.1161/HYPERTENSIONAHA.109.130351 – ident: e_1_3_4_78_2 doi: 10.1016/0005-2744(78)90121-3 – ident: e_1_3_4_26_2 doi: 10.1073/pnas.0605907103 – ident: e_1_3_4_114_2 doi: 10.1161/HYPERTENSIONAHA.118.12005 – ident: e_1_3_4_151_2 doi: 10.1089/ars.2015.6254 – ident: e_1_3_4_53_2 doi: 10.1161/JAHA.117.007157 – volume: 32 start-page: 638 year: 1994 ident: e_1_3_4_113_2 article-title: Pharmacokinetics and safety of intravenous recombinant human superoxide dismutase (NK341) in healthy subjects. publication-title: Int J Clin Pharmacol Ther contributor: fullname: Uematsu T – ident: e_1_3_4_42_2 doi: 10.1152/ajpheart.1991.260.1.H242 – ident: e_1_3_4_143_2 doi: 10.1007/s00210-011-0712-0 – ident: e_1_3_4_167_2 doi: 10.1056/NEJMoa1915928 – ident: e_1_3_4_8_2 doi: 10.1161/01.res.61.6.866 – ident: e_1_3_4_102_2 doi: 10.1073/pnas.84.18.6340 – ident: e_1_3_4_160_2 doi: 10.1074/jbc.M109.064873 – ident: e_1_3_4_77_2 doi: 10.1016/j.freeradbiomed.2020.11.001 – ident: e_1_3_4_120_2 doi: 10.1016/j.bcp.2013.03.023 – ident: e_1_3_4_48_2 doi: 10.1172/JCI116907 – ident: e_1_3_4_189_2 doi: 10.3892/ijmm.2013.1459 – ident: e_1_3_4_68_2 doi: 10.3109/10715762.2015.1089987 – ident: e_1_3_4_164_2 doi: 10.2174/0929867323666160428110059 – ident: e_1_3_4_185_2 doi: 10.1074/jbc.M501527200 – ident: e_1_3_4_107_2 doi: 10.1152/japplphysiol.00513.2006 – ident: e_1_3_4_64_2 doi: 10.1172/JCI28371 – ident: e_1_3_4_101_2 doi: 10.1152/ajpregu.00124.2004 – ident: e_1_3_4_93_2 doi: 10.1016/S0021-9258(18)55297-2 – ident: e_1_3_4_139_2 doi: 10.2174/1389450119666180816120816 – ident: e_1_3_4_125_2 doi: 10.1172/jci.insight.129183 – ident: e_1_3_4_14_2 doi: 10.1073/pnas.79.9.2870 – ident: e_1_3_4_46_2 doi: 10.1111/apha.12649 – ident: e_1_3_4_74_2 doi: 10.1161/CIRCRESAHA.111.259242 – ident: e_1_3_4_38_2 doi: 10.1161/hypertensionaha.116.08171 – ident: e_1_3_4_130_2 doi: 10.1016/j.vph.2019.03.004 – volume: 9 start-page: 145 year: 1978 ident: e_1_3_4_11_2 article-title: Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin. publication-title: Adv Cyclic Nucleotide Res contributor: fullname: Murad F – ident: e_1_3_4_145_2 doi: 10.1016/j.freeradbiomed.2018.11.002 – ident: e_1_3_4_37_2 doi: 10.1161/ATVBAHA.114.303974 – ident: e_1_3_4_88_2 doi: 10.1146/annurev-physiol-020518-114417 – ident: e_1_3_4_106_2 doi: 10.1161/01.hyp.28.4.569 – ident: e_1_3_4_173_2 doi: 10.1152/ajplung.00119.2005 – ident: e_1_3_4_56_2 doi: 10.1073/pnas.0609778104 – ident: e_1_3_4_52_2 doi: 10.1089/ars.2012.4599 – ident: e_1_3_4_90_2 doi: 10.1126/science.1144318 – volume: 35 start-page: 354 year: 1960 ident: e_1_3_4_126_2 article-title: Effects of hydrogen peroxide on normal and hypertensive rats. publication-title: Pharm Acta Helv contributor: fullname: Romanowski A – ident: e_1_3_4_58_2 doi: 10.1073/pnas.91.7.2592 – ident: e_1_3_4_98_2 doi: 10.1016/j.redox.2018.101072 – ident: e_1_3_4_76_2 doi: 10.1007/112_0603 – ident: e_1_3_4_82_2 doi: 10.1097/FJC.0b013e31822d80a5 – ident: e_1_3_4_95_2 doi: 10.1161/01.hyp.13.6.859 – ident: e_1_3_4_121_2 doi: 10.1007/BF02535072 – ident: e_1_3_4_89_2 doi: 10.1021/acs.biochem.5b00572 – ident: e_1_3_4_105_2 doi: 10.1161/HYPERTENSIONAHA.110.159301 – ident: e_1_3_4_156_2 doi: 10.1093/cvr/cvt341 – ident: e_1_3_4_73_2 doi: 10.1152/physrev.00046.2003 – ident: e_1_3_4_182_2 doi: 10.1038/sj.jhh.1002138 – ident: e_1_3_4_32_2 doi: 10.1016/0022-2836(75)90382-4 – ident: e_1_3_4_141_2 doi: 10.1016/j.redox.2015.06.009 – ident: e_1_3_4_117_2 doi: 10.1152/ajpheart.00089.2013 – ident: e_1_3_4_152_2 doi: 10.1074/jbc.M603357200 – ident: e_1_3_4_20_2 doi: 10.1080/10739680902744404 – ident: e_1_3_4_21_2 doi: 10.1152/physiol.00042.2013 – ident: e_1_3_4_63_2 doi: 10.1016/j.febslet.2007.12.025 – ident: e_1_3_4_118_2 doi: 10.1093/cvr/cvr110 – ident: e_1_3_4_127_2 doi: 10.1073/pnas.88.22.10045 – ident: e_1_3_4_177_2 doi: 10.1152/ajplung.00062.2009 – ident: e_1_3_4_83_2 doi: 10.1074/jbc.M117.787390 – ident: e_1_3_4_10_2 doi: 10.1038/288373a0 – ident: e_1_3_4_119_2 doi: 10.1093/cvr/cvt147 – ident: e_1_3_4_181_2 doi: 10.1165/rcmb.2017-0292OC – ident: e_1_3_4_122_2 doi: 10.1111/j.1471-4159.1990.tb01889.x – ident: e_1_3_4_71_2 doi: 10.1152/ajpheart.01025.2002 – ident: e_1_3_4_148_2 doi: 10.1016/j.vph.2017.11.003 – ident: e_1_3_4_6_2 doi: 10.1038/nrdp.2018.14 – ident: e_1_3_4_62_2 doi: 10.1074/jbc.M114.559393 – ident: e_1_3_4_170_2 doi: 10.1038/sj.bjp.0700982 – ident: e_1_3_4_43_2 doi: 10.1161/01.hyp.16.2.162 – ident: e_1_3_4_112_2 doi: 10.1097/HJH.0000000000000422 – ident: e_1_3_4_19_2 doi: 10.1016/s0022-5320(67)80239-9 – ident: e_1_3_4_25_2 doi: 10.1161/ATVBAHA.110.215939 – ident: e_1_3_4_41_2 doi: 10.1016/0090-6980(76)90125-8 – ident: e_1_3_4_135_2 doi: 10.1111/apha.13080 – ident: e_1_3_4_144_2 doi: 10.1016/j.yjmcc.2019.06.012 – ident: e_1_3_4_66_2 doi: 10.1006/abbi.1997.0408 – ident: e_1_3_4_45_2 doi: 10.1038/24388 – ident: e_1_3_4_169_2 doi: 10.1056/NEJMoa1209655 – ident: e_1_3_4_176_2 doi: 10.1152/ajpheart.51.2008 – ident: e_1_3_4_100_2 doi: 10.1182/bloodadvances.2019000527 – ident: e_1_3_4_124_2 doi: 10.1139/o92-065 – ident: e_1_3_4_155_2 doi: 10.1016/j.freeradbiomed.2009.10.046 – ident: e_1_3_4_154_2 doi: 10.1016/j.niox.2018.03.012 – ident: e_1_3_4_60_2 doi: 10.1186/1472-6807-10-2 – ident: e_1_3_4_28_2 doi: 10.1073/pnas.0511118103 – ident: e_1_3_4_150_2 doi: 10.1016/j.redox.2016.04.001 – ident: e_1_3_4_5_2 doi: 10.1001/jama.1949.02900400005002 – ident: e_1_3_4_57_2 doi: 10.1006/bbrc.1999.1444 – ident: e_1_3_4_35_2 doi: 10.1074/jbc.M114.629964 – ident: e_1_3_4_97_2 doi: 10.1152/ajpheart.1986.250.5.H822 – ident: e_1_3_4_133_2 doi: 10.1080/14728222.2017.1310840 – ident: e_1_3_4_55_2 doi: 10.1161/CIRCULATIONAHA.109.890962 – ident: e_1_3_4_81_2 doi: 10.1073/pnas.0703944104 – ident: e_1_3_4_172_2 doi: 10.1038/sj.bjp.0704483 – ident: e_1_3_4_128_2 doi: 10.1097/00004872-199816030-00006 – ident: e_1_3_4_108_2 doi: 10.1161/CIRCRESAHA.117.310933 – ident: e_1_3_4_51_2 doi: 10.1161/CIRCULATIONAHA.119.043385 – ident: e_1_3_4_131_2 doi: 10.3389/fphys.2018.00258 – ident: e_1_3_4_111_2 doi: 10.1172/JCI87425 – ident: e_1_3_4_33_2 doi: 10.1016/s0162-0134(00)80291-3 – ident: e_1_3_4_103_2 doi: 10.1016/j.freeradbiomed.2009.05.018 – ident: e_1_3_4_67_2 doi: 10.1159/000371491 – ident: e_1_3_4_80_2 doi: 10.1073/pnas.89.1.444 – ident: e_1_3_4_109_2 doi: 10.1093/cvr/cvn182 – ident: e_1_3_4_94_2 doi: 10.1161/01.hyp.34.4.539 – ident: e_1_3_4_110_2 doi: 10.1161/01.HYP.0000235682.47673.ab – ident: e_1_3_4_157_2 doi: 10.1016/j.redox.2018.11.008 – ident: e_1_3_4_34_2 doi: 10.1021/bi960442g – ident: e_1_3_4_168_2 doi: 10.1056/NEJMoa1209657 – ident: e_1_3_4_161_2 doi: 10.1111/j.1751-7176.2012.00669.x – start-page: 222 year: 2018 ident: e_1_3_4_186_2 article-title: Age-related endothelial dysfunction in human skeletal muscle feed arteries: the role of free radicals derived from mitochondria in the vasculature. publication-title: Acta Physiol (Oxf) contributor: fullname: Park SY – ident: e_1_3_4_12_2 doi: 10.1038/377239a0 – ident: e_1_3_4_86_2 doi: 10.1111/j.1432-1033.1991.tb16509.x – ident: e_1_3_4_29_2 doi: 10.1016/j.bbalip.2016.04.014 – ident: e_1_3_4_175_2 doi: 10.1164/rccm.200707-1121OC – ident: e_1_3_4_61_2 doi: 10.1073/pnas.1205854109 – ident: e_1_3_4_47_2 doi: 10.1161/01.res.78.3.415 – ident: e_1_3_4_3_2 doi: 10.1161/CIR.0000000000000597 – ident: e_1_3_4_115_2 doi: 10.1016/j.freeradbiomed.2021.03.011 – ident: e_1_3_4_180_2 doi: 10.1021/bi301657w – ident: e_1_3_4_13_2 doi: 10.1016/S0021-9258(19)49528-8 – volume: 50 start-page: 1 year: 1996 ident: e_1_3_4_65_2 article-title: Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. publication-title: Mol Pharmacol contributor: fullname: Schrammel A – ident: e_1_3_4_165_2 doi: 10.1007/s11906-013-0377-9 – volume: 11 start-page: 273 year: 1975 ident: e_1_3_4_188_2 article-title: Bioenergetics in clinical medicine. Studies on coenzyme Q10 and essential hypertension. publication-title: Res Commun Chem Pathol Pharmacol contributor: fullname: Yamagami T – ident: e_1_3_4_99_2 doi: 10.1016/j.freeradbiomed.2017.02.049 – ident: e_1_3_4_7_2 doi: 10.1073/pnas.84.24.9265 – ident: e_1_3_4_159_2 doi: 10.1111/cts.12672 – ident: e_1_3_4_87_2 doi: 10.1016/j.ijms.2010.07.021 – ident: e_1_3_4_178_2 doi: 10.1038/sj.bjp.0704778 – ident: e_1_3_4_85_2 doi: 10.1126/science.286.5444.1583 – ident: e_1_3_4_162_2 doi: 10.1007/s11255-015-1071-4 – ident: e_1_3_4_153_2 doi: 10.1016/j.niox.2018.05.002 – ident: e_1_3_4_104_2 doi: 10.1152/ajpregu.90843.2008 – ident: e_1_3_4_31_2 doi: 10.1177/1358863X17722211 – ident: e_1_3_4_44_2 doi: 10.1006/bbrc.1997.6878 – ident: e_1_3_4_96_2 doi: 10.1161/01.hyp.23.2.229 – ident: e_1_3_4_22_2 doi: 10.1073/pnas.94.12.6529 – ident: e_1_3_4_116_2 doi: 10.1093/eurheartj/ehu436 – ident: e_1_3_4_59_2 doi: 10.1038/s41598-020-66310-4 – ident: e_1_3_4_92_2 doi: 10.1172/JCI80275 – ident: e_1_3_4_17_2 doi: 10.1124/pr.112.007351 – ident: e_1_3_4_36_2 doi: 10.1172/JCI99933 – ident: e_1_3_4_72_2 doi: 10.1074/jbc.M411545200 – ident: e_1_3_4_18_2 doi: 10.1083/jcb.3.3.457 – ident: e_1_3_4_54_2 doi: 10.1073/pnas.2023130118 – ident: e_1_3_4_69_2 doi: 10.1097/FJC.0000000000000173 – ident: e_1_3_4_24_2 doi: 10.1242/jcs.037481 – ident: e_1_3_4_27_2 doi: 10.1152/ajpheart.00614.2009 – ident: e_1_3_4_123_2 doi: 10.1161/HYPERTENSIONAHA.113.01445 |
| SSID | ssj0014447 |
| Score | 2.4624646 |
| SecondaryResourceType | review_article |
| Snippet | The arterial resistance vasculature modulates blood pressure and flow to match oxygen delivery to tissue metabolic demand. As such, resistance arteries and... |
| SourceID | proquest crossref pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 912 |
| SubjectTerms | Blood Pressure - physiology Cell Communication Cyclic GMP-Dependent Protein Kinases - physiology Endothelial Cells - physiology Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - physiology Nitric Oxide - physiology Oxidation-Reduction Signal Transduction - physiology Vascular Resistance - physiology |
| Title | Redox Switches Controlling Nitric Oxide Signaling in the Resistance Vasculature and Implications for Blood Pressure Regulation: Mid-Career Award for Research Excellence 2020 |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34420371 https://search.proquest.com/docview/2563697445 |
| Volume | 78 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLa2IU28oHFdN0CexFuU0sSuk_BWRllBaod2QeUpSmK3i9DSqU1E4T_xHznHzm2DCdhLVEW1czlfjr9z_B2bkFfC8aUCJmIDO1A2TwS3454nbRH3edKPExYJLBQeT8TonH-c9qcbm_st1VKRx93kxx_rSu5iVTgHdsUq2f-wbN0pnIDfYF84goXh-E82PlFysbZOv6X46vXmmyg71wXmkxSX3reO16lU1mk6R75tqleQaZ6oFfJG_Kg_GylqPZHwoS0xRw3iW5S2l2WES2w6L3f8wmTCOJU2ljCh0h71t7pFpeazhms9L4CXcXtur02ERxD_LrV6XsPPf4cJfSNZUuuu5QRe0E5SLKNLfJDxQhZXClj_qsguC_t4XmSxliMM8jQrvtYgPcIdYr43MxzWYbd2b0WZ8r0oorSZhrqA_nMzDqcytcbddjrEdWphXZ0hDTh68KkZ4Eqv7nIbmCJru33Pb8Gbt3x4UOq6DR0ITEH_7yONwJFm9OXTEOKOCQ58gxFmlp0uBKBm08frq3vfGHVrLaSOwoQT3ugqhK5C3dUmueeCF0W94tG01i9BIMzLtQDM826Tg_K-Xt96V9fJ1y0RlWZWZzvkQRkS0YHB90OyobJHZHtcij4ek58a5rSCOW3BnBqYUw1zWsOcphkFmNMG5rQFcwowp22YUwAt1TCnFcxpA_M3tAE51SDX_69AThuQUwT5E3L-fnh2OLLLXUbshAk_t32fKR4Fs0hxJiJgv34ceUJwIRRET47ygx7SPEfNfAbhSuQLj81cT8ie58q-p9hTspUtMrVLqDcTzIkdyUUAb1sl_gwac6kYNPeYZB3iVq8_vDKLyYR_NX-HHFSGCsH14yNFmVoUqxCiFSYCj_N-hzwzFqy7ZZy7uBrn3l0uuU_uN5_Wc7KVLwv1Arh3Hr_UGPwFFjDWVQ |
| link.rule.ids | 315,783,787,27938,27939 |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Redox+Switches+Controlling+Nitric+Oxide+Signaling+in+the+Resistance+Vasculature+and+Implications+for+Blood+Pressure+Regulation%3A+Mid-Career+Award+for+Research+Excellence+2020&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+1979%29&rft.au=Aramide+Modupe+Dosunmu-Ogunbi%2C+Atinuke&rft.au=Galley%2C+Joseph+C.&rft.au=Yuan%2C+Shuai&rft.au=Schmidt%2C+Heidi+M.&rft.date=2021-10-01&rft.issn=0194-911X&rft.eissn=1524-4563&rft.volume=78&rft.issue=4&rft.spage=912&rft.epage=926&rft_id=info:doi/10.1161%2FHYPERTENSIONAHA.121.16493&rft.externalDBID=n%2Fa&rft.externalDocID=10_1161_HYPERTENSIONAHA_121_16493 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0194-911X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0194-911X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0194-911X&client=summon |