Risk of osteonecrosis in systemic lupus erythematosus: An 11-year Chinese single-center cohort study

• Published in: Lupus Vol. 30; no. 9; pp. 1459 - 1468
• Main Authors: Long, Yin, Zhang, Shangzhu, Zhao, Jiuliang, You, Hanxiao, Zhang, Li, Li, Jing, Leng, Xiaomei, Wang, Qian, Tian, Xinping, Li, Mengtao, Zeng, Xiaofeng
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2021; Sage Publications Ltd
• Subjects: Adolescent; Adult; Antibodies, Antiphospholipid - blood; Antiphospholipid antibodies; Antirheumatic Agents - therapeutic use; Arthritis; Central nervous system; China - epidemiology; Cohort analysis; Cohort Studies; Female; Femur; Femur Head Necrosis - blood; Femur Head Necrosis - epidemiology; Femur Head Necrosis - etiology; Glucocorticoids; Glucocorticoids - adverse effects; Glucocorticoids - therapeutic use; Humans; Hydroxychloroquine; Hydroxychloroquine - therapeutic use; Lupus; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - drug therapy; Lupus Erythematosus, Systemic - epidemiology; Male; Medical prognosis; Osteonecrosis; Osteonecrosis - blood; Osteonecrosis - epidemiology; Osteonecrosis - etiology; Patients; Phospholipids; Prednisolone; Prednisolone - adverse effects; Prednisolone - therapeutic use; Prevalence; Risk Factors; Survival; Systemic lupus erythematosus; Young Adult; China; anti-phospholipid antibodies; risk factors; osteonecrosis; Systemic lupus erythematosus

Objective Osteonecrosis (ON), which can lead to physical disability, is a common complication of systemic lupus erythematosus (SLE). The purpose of this study was to determine the prevalence of ON and identify possible risk factors in Chinese SLE patients. Methods SLE patients who fulfilled the 1997...