Prenatal Cocaine Exposure and Cardiometabolic Disease Risk Factors in 18- to 20-Year-Old African Americans

The long-term effects of prenatal cocaine exposure (PCE) on physical health are largely unknown. No human studies support or refute a relationship between PCE and the long-term risk for cardiovascular and/or metabolic disease. We investigated the association of PCE on primary cardiometabolic disease...

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Published inEthnicity & disease Vol. 25; no. 4; pp. 419 - 426
Main Authors Messiah, Sarah E., Ludwig, David A., Vidot, Denise C., Accornero, Veronica H., Lipshultz, Steven E., Miller, Tracie L., Xue, Lihua, Bandstra, Emmalee S.
Format Journal Article
LanguageEnglish
Published United States Ethnicity & Disease, Inc 05.11.2015
International Society on Hypertension in Blacks
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Abstract The long-term effects of prenatal cocaine exposure (PCE) on physical health are largely unknown. No human studies support or refute a relationship between PCE and the long-term risk for cardiovascular and/or metabolic disease. We investigated the association of PCE on primary cardiometabolic disease risk factors in African Americans (AA) aged 18 to 20 years. Cohort, longitudinal, prospective. Miami-Dade County, Florida, and the University of Miami Miller School of Medicine/Jackson Memorial Medical Center. Healthy full-term inner-city AA adolescents (aged 18 to 20 years, n=350) previously enrolled at birth from 1990-1993. Fasting serum insulin, glucose, lipids, and high-sensitivity C-reactive protein; systolic and diastolic blood pressures; and the components and prevalence of the metabolic syndrome. There were no PCE-associated differences in cardiometabolic disease risk factors including the metabolic syndrome and its individual components in AAs aged 18 to 20 years. The results of our study do not support an association between PCE and increased cardiometabolic disease risk in AAs aged 18 to 20 years. Whether PCE is associated with cardiovascular or metabolic disease in adulthood would require further investigation.
AbstractList Objective: The long-term effects of prenatal cocaine exposure (PCE) on physical health are largely unknown. No human studies support or refute a relationship between PCE and the long-term risk for cardiovascu­lar and/or metabolic disease. We investi­gated the association of PCE on primary car­diometabolic disease risk factors in African Americans (AA) aged 18 to 20 years. Design: Cohort, longitudinal, prospective. Setting: Miami-Dade County, Florida, and the University of Miami Miller School of Medicine/Jackson Memorial Medical Center. Participants: Healthy full-term inner-city AA adolescents (aged 18 to 20 years, N=350) previously enrolled at birth from 1990-1993. Main Outcome Measures: Fasting serum insulin, glucose, lipids, and high-sensitivity C-reactive protein; systolic and diastolic blood pressures; and the components and prevalence of the metabolic syndrome. Results: There were no PCE-associated differences in cardiometabolic disease risk factors including the metabolic syndrome and its individual components in AAs aged 18 to 20 years. Conclusions: The results of our study do not support an association between PCE and increased cardiometabolic disease risk in AAs aged 18 to 20 years. Whether PCE is associated with cardiovascular or metabolic disease in adulthood would require further investigation. Ethn Dis. 2015;25(4):419- 426; doi:10.18865/ed.25.4.419
OBJECTIVEThe long-term effects of prenatal cocaine exposure (PCE) on physical health are largely unknown. No human studies support or refute a relationship between PCE and the long-term risk for cardiovascular and/or metabolic disease. We investigated the association of PCE on primary cardiometabolic disease risk factors in African Americans (AA) aged 18 to 20 years.DESIGNCohort, longitudinal, prospective.SETTINGMiami-Dade County, Florida, and the University of Miami Miller School of Medicine/Jackson Memorial Medical Center.PARTICIPANTSHealthy full-term inner-city AA adolescents (aged 18 to 20 years, n=350) previously enrolled at birth from 1990-1993.MAIN OUTCOME MEASURESFasting serum insulin, glucose, lipids, and high-sensitivity C-reactive protein; systolic and diastolic blood pressures; and the components and prevalence of the metabolic syndrome.RESULTSThere were no PCE-associated differences in cardiometabolic disease risk factors including the metabolic syndrome and its individual components in AAs aged 18 to 20 years.CONCLUSIONSThe results of our study do not support an association between PCE and increased cardiometabolic disease risk in AAs aged 18 to 20 years. Whether PCE is associated with cardiovascular or metabolic disease in adulthood would require further investigation.
The long-term effects of prenatal cocaine exposure (PCE) on physical health are largely unknown. No human studies support or refute a relationship between PCE and the long-term risk for cardiovascular and/or metabolic disease. We investigated the association of PCE on primary cardiometabolic disease risk factors in African Americans (AA) aged 18 to 20 years. Cohort, longitudinal, prospective. Miami-Dade County, Florida, and the University of Miami Miller School of Medicine/Jackson Memorial Medical Center. Healthy full-term inner-city AA adolescents (aged 18 to 20 years, n=350) previously enrolled at birth from 1990-1993. Fasting serum insulin, glucose, lipids, and high-sensitivity C-reactive protein; systolic and diastolic blood pressures; and the components and prevalence of the metabolic syndrome. There were no PCE-associated differences in cardiometabolic disease risk factors including the metabolic syndrome and its individual components in AAs aged 18 to 20 years. The results of our study do not support an association between PCE and increased cardiometabolic disease risk in AAs aged 18 to 20 years. Whether PCE is associated with cardiovascular or metabolic disease in adulthood would require further investigation.
Author Xue, Lihua
Bandstra, Emmalee S.
Accornero, Veronica H.
Ludwig, David A.
Messiah, Sarah E.
Vidot, Denise C.
Miller, Tracie L.
Lipshultz, Steven E.
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Keywords Birth Weight
Cardiometabolic Risk Factors
Prenatal Cocaine Exposure
Adolescents
Metabolic Syndrom
African American
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Research concept and design: Messiah, Lipshultz, Miller, Bandstra. Acquisition of data: Messiah, Vidot, Accornero, Lipshultz, Xue, Bandstra. Data analysis and interpretation: Messiah, Ludwig, Vidot, Xue, Bandstra. Manuscript draft: Messiah, Ludwig, Vidot, Accornero, Miller, Xue, Bandstra. Statistical expertise: Messiah, Ludwig, Vidot, Xue. Acquisition of funding: Messiah, Ludwig, Accornero, Miller, Bandstra. Administrative: Messiah, Ludwig, Vidot, Accornero, Xue, Bandstra. Supervision: Messiah, Ludwig, Lipshultz, Miller, Bandstra.
Competing Interests: None declared.
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SubjectTerms Adolescent
African Americans
Blood Pressure
C-Reactive Protein - metabolism
Case-Control Studies
Cocaine-Related Disorders - ethnology
Cohort Studies
Fasting
Female
Florida
Humans
Lipids - blood
Male
Metabolic Syndrome - ethnology
Original Report: Cardiovascular Disease and Risk Factors
Pregnancy
Prenatal Exposure Delayed Effects - ethnology
Prevalence
Risk Factors
Young Adult
Title Prenatal Cocaine Exposure and Cardiometabolic Disease Risk Factors in 18- to 20-Year-Old African Americans
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