Template occluded SBA-15: An effective dissolution enhancer for poorly water-soluble drug

• Published in: Applied surface science Vol. 256; no. 23; pp. 6963 - 6968
• Main Authors: Tingming, Fu, Liwei, Guo, Kang, Le, Tianyao, Wang, Jin, Lu
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.09.2010; Elsevier
• Subjects: Assembling; Calorimetry; Condensed matter: electronic structure, electrical, magnetic, and optical properties; Condensed matter: structure, mechanical and thermal properties; Cross-disciplinary physics: materials science; rheology; Diffraction; Dissolution; Dissolution rate; Drugs; Exact sciences and technology; In vitro testing; Inclusions; Materials science; Materials testing; Mesoporous silica; Physics; Piroxicam; Single-crystal and powder diffraction; Strategy; Structure of solids and liquids; crystallography; Template occluded; Thermal analysis, differential thermal analysis (DTA), differential thermogravimetric analysis; Ultraviolet; X-ray diffraction and scattering; Template occluded; Piroxicam; Dissolution rate; Mesoporous silica; Differential scanning calorimetry; Inorganic compounds; Porous materials; Thermogravimetry; Desorption; XRD; Amorphous state; Dissolution; Mesoporosity; Template; Self-assembly; Silicon oxides; Inclusion compounds
• ISSN: 0169-4332; 1873-5584
• DOI: 10.1016/j.apsusc.2010.05.007

The aim of the present work was to improve the dissolution rate of piroxicam by inclusion into template occluded SBA-15. Our strategy involves directly introducing piroxicam into as-prepared SBA-15 occluded with P123 (EO 20PO 70EO 20) by self assembling method in acetonitrile/methylene chloride mixture solution. Ultraviolet spectrometry experiment and thermogravimetric analysis-differential scanning calorimetry (TG-DSC) profiles show that the piroxicam and P123 contents in the inclusion compound are 12 wt% and 28 wt%, respectively. X-ray powder diffraction and DSC analysis reveal that the included piroxicam is arranged in amorphous form. N 2 adsorption–desorption experiment indicates that the piroxicam has been introduced to the mesopores instead of precipitating at the outside of the silica material. The inclusion compound was submitted to in vitro dissolution tests, the results show that the piroxicam dissolve from template occluded inclusion compound more rapidly, than these from the piroxicam crystalline and template removed samples in all tested conditions. Thus a facile method to improve the dissolution rate of poorly water-soluble drug was established, and this discovery opens a new avenue for the utilization of templates used for the synthesis of mesoporous materials.