The effect of dehydroepiandrosterone (DHEA) supplementation on estradiol levels in women: A dose-response and meta-analysis of randomized clinical trials

• Published in: Steroids Vol. 173; p. 108889
• Main Authors: Zhu, Yan, Qiu, Lei, Jiang, Fangfang, Găman, Mihnea-Alexandru, Abudoraehem, Ohoud Saleh, Okunade, Kehinde S., Zhang, Ming
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2021
• Subjects: Aged; Dehydroepiandrosterone - pharmacokinetics; Dehydroepiandrosterone - therapeutic use; DHEA; Dietary Supplements; Estradiol; Estradiol - blood; Estrogen; Female; Humans; Menopause; Meta-analysis; Middle Aged; Postmenopause - blood; Postmenopause - drug effects; Randomized Controlled Trials as Topic; Women; DHEA; Women; Estradiol; Menopause; Estrogen; Meta-analysis

•DHEA supplementation was associated with increase in estradiol in women.•Estradiol levels increased significantly with DHEA dosages of 50 mg/day.•Estradiol was significantly greater increased in subjects aged ≥60 years old. Estradiol, an estrogen steroid hormone, serves as the dominant female hormo...