Cortical thickness analysis in temporal lobe epilepsy: reproducibility and relation to outcome

• Published in: Neurology Vol. 74; no. 22; p. 1776
• Main Authors: Bernhardt, Boris C, Bernasconi, Neda, Concha, Luis, Bernasconi, Andrea
• Format: Journal Article
• Language: English
• Published: United States 01.06.2010
• Subjects: Adolescent; Adult; Aged; Atrophy - etiology; Atrophy - pathology; Case-Control Studies; Cerebral Cortex - pathology; Epilepsy, Temporal Lobe - complications; Epilepsy, Temporal Lobe - pathology; Epilepsy, Temporal Lobe - surgery; Female; Humans; Image Processing, Computer-Assisted - methods; Longitudinal Studies; Magnetic Resonance Imaging - methods; Male; Middle Aged; Reproducibility of Results; Statistics as Topic; Treatment Outcome; Young Adult

To assess the reproducibility of neocortical atrophy and its clinical significance across the spectrum of temporal lobe epilepsy (TLE), in particular with respect to postsurgical outcome. MRI-based cortical thickness measurement was obtained in 105 patients. A total of 58 had hippocampal atrophy on...