Steady-State Pharmacokinetics and Tolerability of Trans-Resveratrol 2000 mg Twice Daily with Food, Quercetin and Alcohol (Ethanol) in Healthy Human Subjects

• Published in: Clinical pharmacokinetics Vol. 49; no. 7; pp. 449 - 454
• Main Authors: la Porte, Charles, Voduc, Nha, Zhang, Guijun, Seguin, Isabelle, Tardiff, Danielle, Singhal, Neera, Cameron, D. William
• Format: Journal Article
• Language: English
• Published: Auckland Adis International 01.07.2010; Wolters Kluwer Health, Inc; Springer Nature B.V
• Subjects: Adult; Alcohol; Alcohol, Denatured; Area Under Curve; Biological and medical sciences; Chromatography, Liquid; Diarrhea - chemically induced; Diet; Dosage and administration; Drug Administration Schedule; Drug Combinations; Drug Tolerance; Ethanol - administration & dosage; Ethanol - pharmacology; Female; General pharmacology; Health aspects; Humans; Liquid chromatography; Male; Mass spectrometry; Medical sciences; Methods; Middle Aged; Pharmacokinetics; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Quercetin; Quercetin - administration & dosage; Quercetin - pharmacology; Resveratrol; Stilbenes - administration & dosage; Stilbenes - blood; Stilbenes - pharmacokinetics; Tandem Mass Spectrometry; Canada; Human; Ethanol; Healthy subject; Toxicity; Antioxidant; Flavonoid; Stilbene derivatives; Alcoholic beverage; Polyphenol; Phytoalexin; Quercetin; Resveratrol; Phenols; Pharmacokinetics; Food

Trans-resveratrol is a polyphenol, which is found in red wine and has cancer chemo-preventive properties and disease-preventive properties. The pharmacokinetics of trans-resveratrol have been investigated in single-dose studies and in studies with relatively low dosages. The present study aimed to i...