Effects of sodium para-aminosalicylic acid on chelation treatment in Pb-exposed mice

• Published in: Toxicology and industrial health p. 7482337231183208
• Main Authors: Li, Yan, Liang, Yuan, Fang, Yuan-Yuan, Chen, Jing, Zheng, Xiao-Wei, Zhou, Wu-Wang, Lu, Li-Li, Aschner, Michael, Ou, Shi-Yan, Jiang, Yue-Ming
• Format: Journal Article
• Language: English
• Published: England 01.08.2023
• Subjects: para-aminosalicylic acid (PAS-Na); graphite furnace atomic absorption spectrometry; mice; essential elements; lead

Lead (Pb) is a corrosion-resistant, heavy, non-ferrous metal. Several metal chelators have been used for the treatment of Pb poisoning. However, the efficacy of sodium para-aminosalicylic acid (PAS-Na) in enhancing Pb excretion has yet to be fully characterized. Healthy male mice (90) were divided i...