Beneficial contribution of a safflower (Carthamus tinctorius L.) polysaccharide on steroid-induced avascular necrosis of the femoral head in rats

A water-soluble polysaccharide (SPS) was purified from dried safflower (Carthamus tinctorius L.) and its structure was identified using a combination of chemical and instrumental analysis. SPS has a repeating backbone of 1,4,6-β-Glcp, which was attached with T-β-Glcp at its C6 position along the mai...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of biological macromolecules Vol. 123; pp. 581 - 586
Main Authors Cui, Daping, Zhao, Dewei, Huang, Shibo
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.02.2019
Subjects
Protective effect
Safflower (Carthamus tinctorius L.) polysaccharide
Steroid-induced avascular necrosis of the femoral head (SANFH)
Protective effect
Safflower (Carthamus tinctorius L.) polysaccharide
Steroid-induced avascular necrosis of the femoral head (SANFH)
Online AccessGet full text

Cover

Abstract A water-soluble polysaccharide (SPS) was purified from dried safflower (Carthamus tinctorius L.) and its structure was identified using a combination of chemical and instrumental analysis. SPS has a repeating backbone of 1,4,6-β-Glcp, which was attached with T-β-Glcp at its C6 position along the main chain in the molar ratio of 1:1. A steroid-induced avascular necrosis of the femoral head (SANFH) model was established in mice injected with dexamethasone (50 mg/kg) twice per week for 6 weeks. Following SPS treatment at 25 and 100 mg/kg for 60 days, the decreased bone mineral density, abnormal histopathological changes, the increased rate of empty lacunae and apoptosis rate of osteocytes of femoral head in mice induced by dexamethasone was significantly reversed. Meanwhile, increased serum hydroxyproline (HOP) and decreased serum hexosamine (HOM) concentration in mice were turned to the opposite trend with increasing dosage of SPS, thus leading to a high rate of HOM/HOP. In conclusion, SPS may serve as a potential agent for the treatment of SANFH.
AbstractList A water-soluble polysaccharide (SPS) was purified from dried safflower (Carthamus tinctorius L.) and its structure was identified using a combination of chemical and instrumental analysis. SPS has a repeating backbone of 1,4,6-β-Glcp, which was attached with T-β-Glcp at its C6 position along the main chain in the molar ratio of 1:1. A steroid-induced avascular necrosis of the femoral head (SANFH) model was established in mice injected with dexamethasone (50 mg/kg) twice per week for 6 weeks. Following SPS treatment at 25 and 100 mg/kg for 60 days, the decreased bone mineral density, abnormal histopathological changes, the increased rate of empty lacunae and apoptosis rate of osteocytes of femoral head in mice induced by dexamethasone was significantly reversed. Meanwhile, increased serum hydroxyproline (HOP) and decreased serum hexosamine (HOM) concentration in mice were turned to the opposite trend with increasing dosage of SPS, thus leading to a high rate of HOM/HOP. In conclusion, SPS may serve as a potential agent for the treatment of SANFH.
Author Huang, Shibo
Zhao, Dewei
Cui, Daping
Author_xml – sequence: 1
  givenname: Daping
  surname: Cui
  fullname: Cui, Daping
– sequence: 2
  givenname: Dewei
  surname: Zhao
  fullname: Zhao, Dewei
  email: zhaodewei2018@163.com, zhaodewei2016@163.com
– sequence: 3
  givenname: Shibo
  surname: Huang
  fullname: Huang, Shibo
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30419325$$D View this record in MEDLINE/PubMed
BookMark eNqFkU1v1DAQhi1URLeFv1D5WA4JnjifN2DFl7QSFzhbjj3RziqxF9sp6s_gH-NoW66cxho977yeeW_YlfMOGbsDUYKA9t2ppNNIftGmrAT0JUAp6vYF20HfDYUQQl6xnYAaih6kuGY3MZ5yt22gf8WupahhkFWzY38-osOJDOmZG-9SoHFN5B33E9c86mma_W8M_H6vQzrqZY08kTPJB8rPQ_mWn_38GLUxRx3IIs_SmDB4sgU5uxq0XD_oaNZZB-7QBB8pbtPTEfmEiw_Z-YjacnI86BRfs5eTniO-eaq37OfnTz_2X4vD9y_f9h8OhZFtn4pGjhM2Om9ihg46FHXd2wpbCTViZ_QwAnTCNKOwtpG6qqwZJjkOXdbJqqvlLbu_zD0H_2vFmNRC0eA8a4d-jaqCjFWdrDe0vaDb72PASZ0DLTo8KhBqi0Od1HMcaotDAagcRxbePXms44L2n-z5_hl4fwEwb_pAGFQ0hC5fjQKapKyn_3n8BQ5io1M
CitedBy_id crossref_primary_10_3389_fphar_2021_767947
crossref_primary_10_1016_j_taap_2023_116649
crossref_primary_10_1111_jcmm_14868
crossref_primary_10_13045_jar_2022_00227
crossref_primary_10_1155_2021_6657639
crossref_primary_10_1016_j_arabjc_2021_103410
crossref_primary_10_1016_j_carbpol_2020_115856
crossref_primary_10_3389_fphar_2021_711004
crossref_primary_10_1016_j_actbio_2020_05_020
Cites_doi 10.1002/(SICI)1097-0126(199801)45:1<27::AID-PI900>3.0.CO;2-9
10.1111/j.1757-7861.2012.00192.x
10.1016/j.carbpol.2011.07.059
10.1007/s10735-014-9571-6
10.1016/j.ijbiomac.2014.10.056
10.1016/0008-6215(84)85242-8
10.1016/j.carbpol.2009.11.033
10.1016/j.carbpol.2012.05.031
10.1002/art.1780401119
10.1016/j.carbpol.2012.02.004
10.1016/j.carbpol.2013.12.033
10.1016/S1470-2045(12)70137-7
10.1248/cpb.57.65
10.1016/j.ijbiomac.2018.04.181
10.1016/j.carbpol.2013.11.061
10.1016/j.ijbiomac.2015.04.026
10.1016/S0163-7258(02)00297-8
10.1016/S0021-9258(19)51149-8
10.1155/2015/165679
10.1016/j.biortech.2007.01.029
10.1042/bj0810384
10.1007/s11926-011-0173-y
10.1007/s100670200078
10.1016/j.carbpol.2015.10.053
10.3892/mmr.2015.4478
10.1007/s00776-007-1129-y
10.3892/ijmm.2014.1644
10.1016/j.ijbiomac.2018.03.124
10.1016/j.carbpol.2014.05.017
10.1016/S0009-9120(76)80075-6
10.1038/s41598-017-10817-w
10.1016/j.carbpol.2012.01.061
ContentType Journal Article
Copyright 2018 Elsevier B.V.
Copyright © 2018 Elsevier B.V. All rights reserved.
Copyright_xml – notice: 2018 Elsevier B.V.
– notice: Copyright © 2018 Elsevier B.V. All rights reserved.
DBID NPM
AAYXX
CITATION
7X8
DOI 10.1016/j.ijbiomac.2018.11.046
DatabaseName PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList
PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1879-0003
EndPage 586
ExternalDocumentID 10_1016_j_ijbiomac_2018_11_046
30419325
S0141813018350207
Genre Journal Article
GroupedDBID ---
--K
--M
.~1
0R~
1B1
1RT
1~.
1~5
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAXUO
ABFRF
ABGSF
ABJNI
ABMAC
ABUDA
ABYKQ
ACDAQ
ACGFO
ACGFS
ACIUM
ACRLP
ADBBV
ADEZE
ADUVX
AEBSH
AEFWE
AEHWI
AEKER
AENEX
AFKWA
AFTJW
AFXIZ
AGHFR
AGUBO
AGYEJ
AIEXJ
AIKHN
AITUG
AJOXV
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
AXJTR
BKOJK
BLXMC
CS3
DOVZS
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FIRID
FNPLU
FYGXN
G-Q
GBLVA
IHE
J1W
KOM
LX3
M41
MO0
N9A
O-L
O9-
OAUVE
OZT
P-8
P-9
P2P
PC.
Q38
ROL
RPZ
SCC
SDF
SDG
SDP
SES
SPCBC
SSU
SSZ
T5K
UNMZH
~02
~G-
AAHBH
AAXKI
AKRWK
NPM
29J
AAQXK
AAYXX
ABFNM
ABXDB
ADMUD
AFJKZ
AGRDE
AHHHB
ASPBG
AVWKF
AZFZN
CITATION
FEDTE
FGOYB
G-2
HLW
HVGLF
HZ~
R2-
RIG
SBG
SEW
UHS
WUQ
7X8
ID FETCH-LOGICAL-c368t-53bfe5a304c9717e0448d2e6314ee7ca9b1170c5b0dd53a22dc9f3b973bf32743
IEDL.DBID .~1
ISSN 0141-8130
IngestDate Fri Oct 25 08:50:50 EDT 2024
Thu Sep 26 17:49:12 EDT 2024
Wed Oct 16 00:49:58 EDT 2024
Fri Feb 23 02:41:17 EST 2024
IsPeerReviewed true
IsScholarly true
Keywords Protective effect
Safflower (Carthamus tinctorius L.) polysaccharide
Steroid-induced avascular necrosis of the femoral head (SANFH)
Language English
License Copyright © 2018 Elsevier B.V. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c368t-53bfe5a304c9717e0448d2e6314ee7ca9b1170c5b0dd53a22dc9f3b973bf32743
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 30419325
PQID 2132727344
PQPubID 23479
PageCount 6
ParticipantIDs proquest_miscellaneous_2132727344
crossref_primary_10_1016_j_ijbiomac_2018_11_046
pubmed_primary_30419325
elsevier_sciencedirect_doi_10_1016_j_ijbiomac_2018_11_046
PublicationCentury 2000
PublicationDate 2019-02-15
PublicationDateYYYYMMDD 2019-02-15
PublicationDate_xml – month: 02
  year: 2019
  text: 2019-02-15
  day: 15
PublicationDecade 2010
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle International journal of biological macromolecules
PublicationTitleAlternate Int J Biol Macromol
PublicationYear 2019
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Weinstein, Manolagas (bb0030) 2005; 12
De Martel, Ferlay, Franceschi, Vignat, Bray, Forman, Plummer (bb0040) 2012; 13
Yuan, Pan, Li, Guo, Liu, Yan (bb0060) 2015; 2015
Sun, Wang, Li, Li, Jiao, Zhang (bb0160) 2008; 99
Pu, Ma, Liu, Ren, Li, Li, Yu, Zhang, Fan (bb0125) 2016; 137
Karim, Cherian, Jauregui, Pierce, Mont (bb0175) 2015; 3
Yamamoto, Irisa, Sugioka, Sueishi (bb0165) 1997; 40
Zhao, Hu (bb0045) 2012; 4
Zha, Zhao, Chen, Wang, Zhang, Zhang, Zhao (bb0105) 2014; 111
Liu, Sun, Yu, Zhang, Yue, Yang, Wang, Liu (bb0130) 2012; 87
Hong, Guo, Kang, Lian, Ding, Guo (bb0190) 2001; 16
Koo, Kim, Kim, Ahn, Cho, Song, Park, Kim, Wang (bb0025) 2002; 21
Cui, Zhao, Wang, Liu, Yang, Xie, Wang, Cheng, Qiu, Ma, Yu, Wu, Long (bb0075) 2018; 116
Luo (bb0135) 2014; 103
Murata, Kumagai, Miyata, Osaki, Shindo (bb0035) 2007; 12
Zhao, Wang, Li (bb0070) 2003; 16
Aminoff (bb0185) 1974; 81
Xu, Wen, Hu, Yu, Zhang, Chen, Pan (bb0170) 2014; 45
Zhao, Huang, Wang, Wang, Xie (bb0065) 2014; 8
Qi, Cao (bb0195) 2001; 11
Neuman, Logan (bb0100) 1950; 184
Shao, Liu, Chen, Fang, Sun (bb0145) 2015; 73
Zhang, Li, Nie, Chen, Wang, Xie (bb0150) 2012; 88
Chokotho, Harrison, Lubega, Mkandawire (bb0010) 2013; 25
Blumenkrantz, Asboe-Hansen (bb0095) 1976; 9
Schäcke, Döcke, Asadullah (bb0015) 2002; 96
Ciucanu, Kerek (bb0090) 1984; 131
Zheng, Dong, Du, Wang, Ding (bb0155) 2015; 79
den Uyl, Bultink, Lems (bb0020) 2011; 13
Xie, Zou, Luo, Qiu, Wei, Luo, Wu, Jiao (bb0085) 2018; 114
Narayanan, Khanchandani, Borkar, Ambati, Roy, Han, Bhoskar, Ragampeta, Gannon, Mysorekar, Karanam (bb0180) 2017; 7
Chen, Li, Peng, Zhou, Fang (bb0005) 2014; 33
Xu, Hong (bb0200) 1998; 6
Liu, Sun, Liu, Yu (bb0080) 2012; 88
De Paula Regina, Heatley, Budd (bb0110) 1998; 45
Rana, Kumar, Soni (bb0140) 2012; 90
Song, Wei, Li, Wu, Xie, Zhang, Wang, Wang (bb0050) 2015; 12
Sun, Li, Liu (bb0115) 2010; 80
Jing, Cui, Chen, Huang, Song, Liu, Lv, Yu (bb0120) 2014; 102
Tung, Ding, Choi, Van Minh, Kim (bb0055) 2009; 57
Chen (10.1016/j.ijbiomac.2018.11.046_bb0005) 2014; 33
Zhao (10.1016/j.ijbiomac.2018.11.046_bb0070) 2003; 16
Pu (10.1016/j.ijbiomac.2018.11.046_bb0125) 2016; 137
Aminoff (10.1016/j.ijbiomac.2018.11.046_bb0185) 1974; 81
Ciucanu (10.1016/j.ijbiomac.2018.11.046_bb0090) 1984; 131
Xu (10.1016/j.ijbiomac.2018.11.046_bb0200) 1998; 6
Xu (10.1016/j.ijbiomac.2018.11.046_bb0170) 2014; 45
Hong (10.1016/j.ijbiomac.2018.11.046_bb0190) 2001; 16
Yuan (10.1016/j.ijbiomac.2018.11.046_bb0060) 2015; 2015
Liu (10.1016/j.ijbiomac.2018.11.046_bb0080) 2012; 88
Yamamoto (10.1016/j.ijbiomac.2018.11.046_bb0165) 1997; 40
Blumenkrantz (10.1016/j.ijbiomac.2018.11.046_bb0095) 1976; 9
Qi (10.1016/j.ijbiomac.2018.11.046_bb0195) 2001; 11
Jing (10.1016/j.ijbiomac.2018.11.046_bb0120) 2014; 102
Zha (10.1016/j.ijbiomac.2018.11.046_bb0105) 2014; 111
Rana (10.1016/j.ijbiomac.2018.11.046_bb0140) 2012; 90
Chokotho (10.1016/j.ijbiomac.2018.11.046_bb0010) 2013; 25
Song (10.1016/j.ijbiomac.2018.11.046_bb0050) 2015; 12
Cui (10.1016/j.ijbiomac.2018.11.046_bb0075) 2018; 116
Weinstein (10.1016/j.ijbiomac.2018.11.046_bb0030) 2005; 12
Neuman (10.1016/j.ijbiomac.2018.11.046_bb0100) 1950; 184
De Martel (10.1016/j.ijbiomac.2018.11.046_bb0040) 2012; 13
Tung (10.1016/j.ijbiomac.2018.11.046_bb0055) 2009; 57
Narayanan (10.1016/j.ijbiomac.2018.11.046_bb0180) 2017; 7
Koo (10.1016/j.ijbiomac.2018.11.046_bb0025) 2002; 21
Sun (10.1016/j.ijbiomac.2018.11.046_bb0115) 2010; 80
Shao (10.1016/j.ijbiomac.2018.11.046_bb0145) 2015; 73
Zheng (10.1016/j.ijbiomac.2018.11.046_bb0155) 2015; 79
Sun (10.1016/j.ijbiomac.2018.11.046_bb0160) 2008; 99
Zhao (10.1016/j.ijbiomac.2018.11.046_bb0065) 2014; 8
Zhang (10.1016/j.ijbiomac.2018.11.046_bb0150) 2012; 88
Schäcke (10.1016/j.ijbiomac.2018.11.046_bb0015) 2002; 96
Murata (10.1016/j.ijbiomac.2018.11.046_bb0035) 2007; 12
Zhao (10.1016/j.ijbiomac.2018.11.046_bb0045) 2012; 4
Luo (10.1016/j.ijbiomac.2018.11.046_bb0135) 2014; 103
Xie (10.1016/j.ijbiomac.2018.11.046_bb0085) 2018; 114
den Uyl (10.1016/j.ijbiomac.2018.11.046_bb0020) 2011; 13
De Paula Regina (10.1016/j.ijbiomac.2018.11.046_bb0110) 1998; 45
Liu (10.1016/j.ijbiomac.2018.11.046_bb0130) 2012; 87
Karim (10.1016/j.ijbiomac.2018.11.046_bb0175) 2015; 3
References_xml – volume: 16
  start-page: 716
  year: 2003
  end-page: 719
  ident: bb0070
  article-title: Experimental study of the Weishi Huogu Capsule NO 1 on the treatment of avascular necrosis of the femoral head
  publication-title: Chin. J. Orthop. Trauma
  contributor:
    fullname: Li
– volume: 33
  start-page: 840
  year: 2014
  end-page: 848
  ident: bb0005
  article-title: Administration of erythropoietin exerts protective effects against glucocorticoid-induced osteonecrosis of the femoral head in rats
  publication-title: Int. J. Mol. Med.
  contributor:
    fullname: Fang
– volume: 114
  start-page: 520
  year: 2018
  end-page: 528
  ident: bb0085
  article-title: Structural characterization and immunomodulating activities of a novel polysaccharide from
  publication-title: Int. J. Biol. Macromol.
  contributor:
    fullname: Jiao
– volume: 80
  start-page: 377
  year: 2010
  end-page: 380
  ident: bb0115
  article-title: Structural characterization and hydroxyl radicals scavenging capacity of a polysaccharide from the fruiting bodies of
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Liu
– volume: 116
  start-page: 106
  year: 2018
  end-page: 112
  ident: bb0075
  article-title: Safflower (
  publication-title: Int. J. Biol. Macromol.
  contributor:
    fullname: Long
– volume: 13
  start-page: 233
  year: 2011
  end-page: 240
  ident: bb0020
  article-title: Advances in glucocorticoid-induced osteoporosis
  publication-title: Curr. Rheumatol. Rep.
  contributor:
    fullname: Lems
– volume: 9
  start-page: 269
  year: 1976
  end-page: 274
  ident: bb0095
  article-title: An assay for total hexosamine and a differential assay for glucosamine and galactosamine
  publication-title: Clin. Biochem.
  contributor:
    fullname: Asboe-Hansen
– volume: 7
  year: 2017
  ident: bb0180
  article-title: Avascular necrosis of femoral head: a metabolomic, biophysical, biochemical, electron microscopic and histopathological characterization
  publication-title: Sci. Rep.
  contributor:
    fullname: Karanam
– volume: 79
  start-page: 674
  year: 2015
  end-page: 680
  ident: bb0155
  article-title: Structural elucidation of a polysaccharide from
  publication-title: Int. J. Biol. Macromol.
  contributor:
    fullname: Ding
– volume: 90
  start-page: 243
  year: 2012
  end-page: 250
  ident: bb0140
  article-title: Structural characterization of an acidic polysaccharide from
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Soni
– volume: 99
  start-page: 900
  year: 2008
  end-page: 904
  ident: bb0160
  article-title: Purification, structure and immunobiological activity of a new water-soluble polysaccharide from the mycelium of
  publication-title: Bioresour. Technol.
  contributor:
    fullname: Zhang
– volume: 2015
  year: 2015
  ident: bb0060
  article-title: Protective effects of total saponins of
  publication-title: Evid. Based Complement. Alternat. Med.
  contributor:
    fullname: Yan
– volume: 12
  start-page: 219
  year: 2005
  end-page: 223
  ident: bb0030
  article-title: Apoptosis in glucocorticoid-induced bone disease
  publication-title: Curr. Opin. Endocrinol. Diabetes Obes.
  contributor:
    fullname: Manolagas
– volume: 40
  start-page: 2055
  year: 1997
  end-page: 2064
  ident: bb0165
  article-title: Effects of pulse methylprednisolone on bone and marrow tissues: corticosteroid-induced osteonecrosis in rabbits
  publication-title: Arthritis Rheum.
  contributor:
    fullname: Sueishi
– volume: 87
  start-page: 348
  year: 2012
  end-page: 352
  ident: bb0130
  article-title: Purification and identification of one glucan from golden oyster mushroom (
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Liu
– volume: 45
  start-page: 473
  year: 2014
  end-page: 485
  ident: bb0170
  article-title: STAT1-caspase 3 pathway in the apoptotic process associated with steroid-induced necrosis of the femoral head
  publication-title: J. Mol. Histol.
  contributor:
    fullname: Pan
– volume: 88
  start-page: 1299
  year: 2012
  end-page: 1303
  ident: bb0080
  article-title: A water-soluble polysaccharide (EFP-AW1) from the alkaline extract of the roots of a traditional Chinese medicine, Euphorbia fischeriana: fraction and characterization
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Yu
– volume: 21
  start-page: 299
  year: 2002
  end-page: 303
  ident: bb0025
  article-title: Risk period for developing osteonecrosis of the femoral head in patients on steroid treatment
  publication-title: Clin. Rheumatol.
  contributor:
    fullname: Wang
– volume: 45
  start-page: 27
  year: 1998
  end-page: 35
  ident: bb0110
  article-title: Characterization of
  publication-title: Polym. Int.
  contributor:
    fullname: Budd
– volume: 102
  start-page: 288
  year: 2014
  end-page: 296
  ident: bb0120
  article-title: Elucidation and biological activities of a new polysaccharide from cultured
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Yu
– volume: 16
  start-page: 365
  year: 2001
  end-page: 368
  ident: bb0190
  article-title: The experimental research of alteration of bone metabolism in steroidinduced necrosis of femoral head
  publication-title: J. Bone Joint Inj.
  contributor:
    fullname: Guo
– volume: 6
  start-page: 8
  year: 1998
  end-page: 12
  ident: bb0200
  article-title: Experimental study of fu yuan san on biochemistry metabolism of steroid-induced necrosis of femoral head in rabbits
  publication-title: Chin. J. Tradit. Med. Trauma Orthop.
  contributor:
    fullname: Hong
– volume: 12
  start-page: 8155
  year: 2015
  end-page: 8161
  ident: bb0050
  article-title: Effects of Wenyangbushen formula on the expression of VEGF, OPG, RANK and RANKL in rabbits with steroid-induced femoral head avascular necrosis
  publication-title: Mol. Med. Rep.
  contributor:
    fullname: Wang
– volume: 111
  start-page: 584
  year: 2014
  end-page: 587
  ident: bb0105
  article-title: Extraction, purification and antioxidant activities of the polysaccharides frommaca (
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Zhao
– volume: 88
  start-page: 1047
  year: 2012
  end-page: 1054
  ident: bb0150
  article-title: Structural characterisation of a novel bioactive polysaccharide from
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Xie
– volume: 11
  start-page: 20
  year: 2001
  end-page: 22
  ident: bb0195
  article-title: Study on animal models of hormonal avascular necrosis of the femoral head
  publication-title: J. Fujian Coll. TCM
  contributor:
    fullname: Cao
– volume: 131
  start-page: 209
  year: 1984
  end-page: 217
  ident: bb0090
  article-title: A simple and rapid method for the permethylation of carbohydrates
  publication-title: Carbohydr. Res.
  contributor:
    fullname: Kerek
– volume: 12
  start-page: 289
  year: 2007
  ident: bb0035
  article-title: Osteonecrosis in stroke-prone spontaneously hypertensive rats: effect of glucocorticoid
  publication-title: J. Orthop. Sci.
  contributor:
    fullname: Shindo
– volume: 103
  start-page: 261
  year: 2014
  end-page: 266
  ident: bb0135
  article-title: Structural investigation of a polysaccharide (DMB) purified from
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Luo
– volume: 3
  year: 2015
  ident: bb0175
  article-title: Osteonecrosis of the knee
  publication-title: Ann. Transl. Med.
  contributor:
    fullname: Mont
– volume: 25
  start-page: 28
  year: 2013
  end-page: 32
  ident: bb0010
  article-title: Avascular necrosis of the femoral head in HIV positive patients-an assessment of risk factors and early response to surgical treatment
  publication-title: Malawi Med. J.
  contributor:
    fullname: Mkandawire
– volume: 13
  start-page: 607
  year: 2012
  end-page: 615
  ident: bb0040
  article-title: Global burden of cancers attributable to infections in 2008: a review and synthetic analysis
  publication-title: Lancet Oncol.
  contributor:
    fullname: Plummer
– volume: 137
  start-page: 154
  year: 2016
  end-page: 164
  ident: bb0125
  article-title: Structural characterization and antioxidant activity in vitro of polysaccharides from angelica and astragalus
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Fan
– volume: 73
  start-page: 124
  year: 2015
  end-page: 130
  ident: bb0145
  article-title: Structural features and antitumor activity of a purified polysaccharide extracted from
  publication-title: Int. J. Biol. Macromol.
  contributor:
    fullname: Sun
– volume: 184
  start-page: 299
  year: 1950
  end-page: 306
  ident: bb0100
  article-title: The determination of hydroxyproline
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Logan
– volume: 4
  start-page: 125
  year: 2012
  end-page: 130
  ident: bb0045
  article-title: Chinese experts' consensus on the diagnosis and treatment of osteonecrosis of the femoral head in adults
  publication-title: Orthop. Surg.
  contributor:
    fullname: Hu
– volume: 8
  start-page: 563
  year: 2014
  end-page: 567
  ident: bb0065
  article-title: Therapeutic evaluation of Weishi Huogu 1 in treating avascular necrosis of femoral head in early middle stage
  publication-title: Chin. J. Joint Surg.
  contributor:
    fullname: Xie
– volume: 81
  start-page: 384
  year: 1974
  end-page: 392
  ident: bb0185
  article-title: Methods for the quantitative estimation of N-acetyl neuraminic acid and their application to hydrosylates of sialomucoids
  publication-title: Biochem. J.
  contributor:
    fullname: Aminoff
– volume: 96
  start-page: 23
  year: 2002
  end-page: 43
  ident: bb0015
  article-title: Mechanisms involved in the side effects of glucocorticoids
  publication-title: Pharmacol. Ther.
  contributor:
    fullname: Asadullah
– volume: 57
  start-page: 65
  year: 2009
  end-page: 68
  ident: bb0055
  article-title: New neolignan component from
  publication-title: Chem. Pharm. Bull. (Tokyo)
  contributor:
    fullname: Kim
– volume: 45
  start-page: 27
  year: 1998
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0110
  article-title: Characterization of Anacardium occidentale exudate polysaccharide
  publication-title: Polym. Int.
  doi: 10.1002/(SICI)1097-0126(199801)45:1<27::AID-PI900>3.0.CO;2-9
  contributor:
    fullname: De Paula Regina
– volume: 4
  start-page: 125
  year: 2012
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0045
  article-title: Chinese experts' consensus on the diagnosis and treatment of osteonecrosis of the femoral head in adults
  publication-title: Orthop. Surg.
  doi: 10.1111/j.1757-7861.2012.00192.x
  contributor:
    fullname: Zhao
– volume: 87
  start-page: 348
  year: 2012
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0130
  article-title: Purification and identification of one glucan from golden oyster mushroom (Pleurotus citrinopileatus (Fr.) Singer)
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2011.07.059
  contributor:
    fullname: Liu
– volume: 6
  start-page: 8
  year: 1998
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0200
  article-title: Experimental study of fu yuan san on biochemistry metabolism of steroid-induced necrosis of femoral head in rabbits
  publication-title: Chin. J. Tradit. Med. Trauma Orthop.
  contributor:
    fullname: Xu
– volume: 45
  start-page: 473
  year: 2014
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0170
  article-title: STAT1-caspase 3 pathway in the apoptotic process associated with steroid-induced necrosis of the femoral head
  publication-title: J. Mol. Histol.
  doi: 10.1007/s10735-014-9571-6
  contributor:
    fullname: Xu
– volume: 73
  start-page: 124
  year: 2015
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0145
  article-title: Structural features and antitumor activity of a purified polysaccharide extracted from Sargassum horneri
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2014.10.056
  contributor:
    fullname: Shao
– volume: 12
  start-page: 219
  year: 2005
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0030
  article-title: Apoptosis in glucocorticoid-induced bone disease
  publication-title: Curr. Opin. Endocrinol. Diabetes Obes.
  contributor:
    fullname: Weinstein
– volume: 131
  start-page: 209
  year: 1984
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0090
  article-title: A simple and rapid method for the permethylation of carbohydrates
  publication-title: Carbohydr. Res.
  doi: 10.1016/0008-6215(84)85242-8
  contributor:
    fullname: Ciucanu
– volume: 25
  start-page: 28
  year: 2013
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0010
  article-title: Avascular necrosis of the femoral head in HIV positive patients-an assessment of risk factors and early response to surgical treatment
  publication-title: Malawi Med. J.
  contributor:
    fullname: Chokotho
– volume: 80
  start-page: 377
  year: 2010
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0115
  article-title: Structural characterization and hydroxyl radicals scavenging capacity of a polysaccharide from the fruiting bodies of Auricularia polytricha
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2009.11.033
  contributor:
    fullname: Sun
– volume: 90
  start-page: 243
  year: 2012
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0140
  article-title: Structural characterization of an acidic polysaccharide from Dalbergia sissoo Roxb. leaves
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2012.05.031
  contributor:
    fullname: Rana
– volume: 3
  year: 2015
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0175
  article-title: Osteonecrosis of the knee
  publication-title: Ann. Transl. Med.
  contributor:
    fullname: Karim
– volume: 11
  start-page: 20
  year: 2001
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0195
  article-title: Study on animal models of hormonal avascular necrosis of the femoral head
  publication-title: J. Fujian Coll. TCM
  contributor:
    fullname: Qi
– volume: 40
  start-page: 2055
  year: 1997
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0165
  article-title: Effects of pulse methylprednisolone on bone and marrow tissues: corticosteroid-induced osteonecrosis in rabbits
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.1780401119
  contributor:
    fullname: Yamamoto
– volume: 88
  start-page: 1299
  year: 2012
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0080
  article-title: A water-soluble polysaccharide (EFP-AW1) from the alkaline extract of the roots of a traditional Chinese medicine, Euphorbia fischeriana: fraction and characterization
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2012.02.004
  contributor:
    fullname: Liu
– volume: 103
  start-page: 261
  year: 2014
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0135
  article-title: Structural investigation of a polysaccharide (DMB) purified from Dioscorea nipponica Makino
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2013.12.033
  contributor:
    fullname: Luo
– volume: 16
  start-page: 365
  year: 2001
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0190
  article-title: The experimental research of alteration of bone metabolism in steroidinduced necrosis of femoral head
  publication-title: J. Bone Joint Inj.
  contributor:
    fullname: Hong
– volume: 13
  start-page: 607
  year: 2012
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0040
  article-title: Global burden of cancers attributable to infections in 2008: a review and synthetic analysis
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(12)70137-7
  contributor:
    fullname: De Martel
– volume: 57
  start-page: 65
  year: 2009
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0055
  article-title: New neolignan component from Camellia amplexicaulis and effects on osteoblast differentiation
  publication-title: Chem. Pharm. Bull. (Tokyo)
  doi: 10.1248/cpb.57.65
  contributor:
    fullname: Tung
– volume: 116
  start-page: 106
  year: 2018
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0075
  article-title: Safflower (Carthamus tinctorius L.) polysaccharide attenuates cellular apoptosis in steroid-induced avascular necrosis of femoral head by targeting caspase-3-dependent signaling pathway
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2018.04.181
  contributor:
    fullname: Cui
– volume: 102
  start-page: 288
  year: 2014
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0120
  article-title: Elucidation and biological activities of a new polysaccharide from cultured Cordyceps militaris
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2013.11.061
  contributor:
    fullname: Jing
– volume: 79
  start-page: 674
  year: 2015
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0155
  article-title: Structural elucidation of a polysaccharide from Chrysanthemum morifolium flowers with anti-angiogenic activity
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2015.04.026
  contributor:
    fullname: Zheng
– volume: 96
  start-page: 23
  year: 2002
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0015
  article-title: Mechanisms involved in the side effects of glucocorticoids
  publication-title: Pharmacol. Ther.
  doi: 10.1016/S0163-7258(02)00297-8
  contributor:
    fullname: Schäcke
– volume: 184
  start-page: 299
  year: 1950
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0100
  article-title: The determination of hydroxyproline
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)51149-8
  contributor:
    fullname: Neuman
– volume: 2015
  year: 2015
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0060
  article-title: Protective effects of total saponins of Panax notoginseng on steroid-induced avascular necrosis of the femoral head in vivo and in vitro
  publication-title: Evid. Based Complement. Alternat. Med.
  doi: 10.1155/2015/165679
  contributor:
    fullname: Yuan
– volume: 16
  start-page: 716
  year: 2003
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0070
  article-title: Experimental study of the Weishi Huogu Capsule NO 1 on the treatment of avascular necrosis of the femoral head
  publication-title: Chin. J. Orthop. Trauma
  contributor:
    fullname: Zhao
– volume: 99
  start-page: 900
  year: 2008
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0160
  article-title: Purification, structure and immunobiological activity of a new water-soluble polysaccharide from the mycelium of Polyporus albicans (Imaz.) Teng
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2007.01.029
  contributor:
    fullname: Sun
– volume: 81
  start-page: 384
  year: 1974
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0185
  article-title: Methods for the quantitative estimation of N-acetyl neuraminic acid and their application to hydrosylates of sialomucoids
  publication-title: Biochem. J.
  doi: 10.1042/bj0810384
  contributor:
    fullname: Aminoff
– volume: 13
  start-page: 233
  year: 2011
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0020
  article-title: Advances in glucocorticoid-induced osteoporosis
  publication-title: Curr. Rheumatol. Rep.
  doi: 10.1007/s11926-011-0173-y
  contributor:
    fullname: den Uyl
– volume: 21
  start-page: 299
  year: 2002
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0025
  article-title: Risk period for developing osteonecrosis of the femoral head in patients on steroid treatment
  publication-title: Clin. Rheumatol.
  doi: 10.1007/s100670200078
  contributor:
    fullname: Koo
– volume: 137
  start-page: 154
  year: 2016
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0125
  article-title: Structural characterization and antioxidant activity in vitro of polysaccharides from angelica and astragalus
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2015.10.053
  contributor:
    fullname: Pu
– volume: 12
  start-page: 8155
  year: 2015
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0050
  article-title: Effects of Wenyangbushen formula on the expression of VEGF, OPG, RANK and RANKL in rabbits with steroid-induced femoral head avascular necrosis
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2015.4478
  contributor:
    fullname: Song
– volume: 12
  start-page: 289
  year: 2007
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0035
  article-title: Osteonecrosis in stroke-prone spontaneously hypertensive rats: effect of glucocorticoid
  publication-title: J. Orthop. Sci.
  doi: 10.1007/s00776-007-1129-y
  contributor:
    fullname: Murata
– volume: 33
  start-page: 840
  year: 2014
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0005
  article-title: Administration of erythropoietin exerts protective effects against glucocorticoid-induced osteonecrosis of the femoral head in rats
  publication-title: Int. J. Mol. Med.
  doi: 10.3892/ijmm.2014.1644
  contributor:
    fullname: Chen
– volume: 8
  start-page: 563
  year: 2014
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0065
  article-title: Therapeutic evaluation of Weishi Huogu 1 in treating avascular necrosis of femoral head in early middle stage
  publication-title: Chin. J. Joint Surg.
  contributor:
    fullname: Zhao
– volume: 114
  start-page: 520
  year: 2018
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0085
  article-title: Structural characterization and immunomodulating activities of a novel polysaccharide from Nervilia fordii
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2018.03.124
  contributor:
    fullname: Xie
– volume: 111
  start-page: 584
  year: 2014
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0105
  article-title: Extraction, purification and antioxidant activities of the polysaccharides frommaca (Lepidium meyenii)
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2014.05.017
  contributor:
    fullname: Zha
– volume: 9
  start-page: 269
  year: 1976
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0095
  article-title: An assay for total hexosamine and a differential assay for glucosamine and galactosamine
  publication-title: Clin. Biochem.
  doi: 10.1016/S0009-9120(76)80075-6
  contributor:
    fullname: Blumenkrantz
– volume: 7
  year: 2017
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0180
  article-title: Avascular necrosis of femoral head: a metabolomic, biophysical, biochemical, electron microscopic and histopathological characterization
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-10817-w
  contributor:
    fullname: Narayanan
– volume: 88
  start-page: 1047
  year: 2012
  ident: 10.1016/j.ijbiomac.2018.11.046_bb0150
  article-title: Structural characterisation of a novel bioactive polysaccharide from Ganoderma atrum
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2012.01.061
  contributor:
    fullname: Zhang
SSID ssj0006518
Score 2.3422484
Snippet A water-soluble polysaccharide (SPS) was purified from dried safflower (Carthamus tinctorius L.) and its structure was identified using a combination of...
SourceID proquest
crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 581
SubjectTerms Protective effect
Safflower (Carthamus tinctorius L.) polysaccharide
Steroid-induced avascular necrosis of the femoral head (SANFH)
Title Beneficial contribution of a safflower (Carthamus tinctorius L.) polysaccharide on steroid-induced avascular necrosis of the femoral head in rats
URI https://dx.doi.org/10.1016/j.ijbiomac.2018.11.046
https://www.ncbi.nlm.nih.gov/pubmed/30419325
https://search.proquest.com/docview/2132727344
Volume 123
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwELYQHNpLBbSlWx5yJQ7twbub2M5ujrAq2j7gVCRulmOPhVeQrJrdAxf-A_-YmTxKKxX10FsS-T2jmW-ceTB2DCEkNveJmLighHI5iAL5WDglJ-CVRBOa4p3PL7L5pfp6pa822KyPhSG3yk72tzK9kdbdl1F3mqNljCNyS0L1hAyKIAJBD0WUK1R_yNPD-yc3j0w3d3zUWFDr36KEF8O4oCB3S6kMk-mQsnkSEP67gnoOgDaK6GybveoQJD9pF7nDNqDcZS9mfeG21-zhFOVXmxiCN57oXUkrXgVueW1DuKHSaPzjDDd6bW_XNV_Fki7vIz5-H37iy-rmrraOIrKiB45dKZ1CFb1ACx55wXPbe7DyEmgfsabREUzyQK67ODMKec9jyZHD6jfs8uzzj9lcdJUXhJPZdCW0LAJoK8dIPLT3YIxGnE8hk4kCmDibF1Swxuli7L2WNk29y4Ms8gn2k2jnyrdss6xKeMd44XPnXQpogoPCoezUgQo6w7WmEIowYKP-uM2yTbBhes-zhekJZIhAaK0YJNCA5T1VzB-sYlAL_LPvh56MBqlCP0dsCdW6Nima5YTllBqwvZa-v9aD50A4V7__j5n32Ut8y8nhO9EHbHP1cw2HiGdWxVHDsEds6-TLt_nFI4d4-Ns
link.rule.ids 315,783,787,4509,24128,27936,27937,45597,45691
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwELaW3cNyQbwpTyNxgIPbJraT-rhUrLpst6ddaW-WY4-FqyWpSHvgZ_CPmWmSFUggDtyiJOPXTMbfOPNg7B3EmDkTMlH6qITyBkSFciy8kiUEJdGEpnjni1WxuFKfr_X1AZsPsTDkVtnr_k6n77V1f2fSr-Zkk9KE3JJwe0IBRRCBoKe8w44QDRj8Oo9Ozs4Xq1uFXOj9MR-9L4jgl0Dh9TitKc7dUTbDbDamhJ6Ehf-8R_0Ng-73otP77F4PIvlJN84H7ADqh-x4PtRue8R-fEQV1uWG4Htn9L6qFW8id7x1Md5QdTT-fo5z_eK-7lq-TTWd3ye8XI4_8E1z8711noKyUgCOpJRRoUlBoBGP4hC4G5xYeQ00j9RS64gneSTvXewZ9XzgqeYoZO1jdnX66XK-EH3xBeFlMdsKLasI2skp8g9NPpiiHRdyKGSmAErvTEU1a7yupiFo6fI8eBNlZUqkk2jqyifssG5qeMZ4FYwPPge0wkFhU27mQUVd4FhziFUcscmw3HbT5diwg_PZ2g4MssQgNFgsMmjEzMAV-5u0WNwI_kn7dmCjRa7Q_xFXQ7NrbY6WOcE5pUbsacff2_HgOhDU1c__o-c37HhxebG0y7PV-Qt2F58Y8v_O9Et2uP22g1cIb7bV6158fwIMj_uP
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Beneficial+contribution+of+a+safflower+%28Carthamus+tinctorius+L.%29+polysaccharide+on+steroid-induced+avascular+necrosis+of+the+femoral+head+in+rats&rft.jtitle=International+journal+of+biological+macromolecules&rft.au=Cui%2C+Daping&rft.au=Zhao%2C+Dewei&rft.au=Huang%2C+Shibo&rft.date=2019-02-15&rft.issn=0141-8130&rft.volume=123&rft.spage=581&rft.epage=586&rft_id=info:doi/10.1016%2Fj.ijbiomac.2018.11.046&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_ijbiomac_2018_11_046
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0141-8130&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0141-8130&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0141-8130&client=summon