Exhaled VOCs can discriminate subjects with COVID-19 from healthy controls

• Published in: Journal of breath research Vol. 16; no. 3; pp. 36002 - 36012
• Main Authors: Woollam, Mark, Angarita-Rivera, Paula, Siegel, Amanda P, Kalra, Vikas, Kapoor, Rajat, Agarwal, Mangilal
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 01.07.2022
• Subjects: Breath Tests - methods; COVID-19; COVID-19 biomarker discovery; Exhalation; exhaled breath; gas chromatography-mass spectrometry quadrupole time-of-flight (GC-MS QTOF); Humans; SARS-CoV-2; solid phase microextraction (SPME); volatile organic compound (VOC); Volatile Organic Compounds - analysis; gas chromatography-mass spectrometry quadrupole time-of-flight (GC-MS QTOF); solid phase microextraction (SPME); volatile organic compound (VOC); COVID-19 biomarker discovery; exhaled breath

COVID-19 detection currently relies on testing by reverse transcription polymerase chain reaction (RT-PCR) or antigen testing. However, SARS-CoV-2 is expected to cause significant metabolic changes in infected subjects due to both metabolic requirements for rapid viral replication and host immune re...