Excited state dynamics of DNA bases
Biochemical reactions are subject to the particular environmental conditions of planet earth, including solar irradiation. How DNA responds to radiation is relevant to human health because radiation damage can affect genetic propagation and lead to cancer and is also important for our understanding...
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Published in | International reviews in physical chemistry Vol. 32; no. 2; pp. 308 - 342 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Abingdon
Routledge
01.06.2013
Taylor & Francis Ltd |
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Abstract | Biochemical reactions are subject to the particular environmental conditions of planet earth, including solar irradiation. How DNA responds to radiation is relevant to human health because radiation damage can affect genetic propagation and lead to cancer and is also important for our understanding of how life on earth developed. A reductionist approach to unravelling the detailed photochemistry seeks to establish intrinsic properties of individual DNA building blocks, followed by extrapolation to larger systems, to incorporate interactions between the building blocks and the role of the biomolecular environment. Advances in both experimental and computational techniques have lead to increasingly detailed insights in the excited state dynamics of DNA bases in isolation as well as the role of the solvent and intermolecular interactions. This review seeks to summarise current findings and understanding. |
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AbstractList | Biochemical reactions are subject to the particular environmental conditions of planet earth, including solar irradiation. How DNA responds to radiation is relevant to human health because radiation damage can affect genetic propagation and lead to cancer and is also important for our understanding of how life on earth developed. A reductionist approach to unravelling the detailed photochemistry seeks to establish intrinsic properties of individual DNA building blocks, followed by extrapolation to larger systems, to incorporate interactions between the building blocks and the role of the biomolecular environment. Advances in both experimental and computational techniques have lead to increasingly detailed insights in the excited state dynamics of DNA bases in isolation as well as the role of the solvent and intermolecular interactions. This review seeks to summarise current findings and understanding. Biochemical reactions are subject to the particular environmental conditions of planet earth, including solar irradiation. How DNA responds to radiation is relevant to human health because radiation damage can affect genetic propagation and lead to cancer and is also important for our understanding of how life on earth developed. A reductionist approach to unravelling the detailed photochemistry seeks to establish intrinsic properties of individual DNA building blocks, followed by extrapolation to larger systems, to incorporate interactions between the building blocks and the role of the biomolecular environment. Advances in both experimental and computational techniques have lead to increasingly detailed insights in the excited state dynamics of DNA bases in isolation as well as the role of the solvent and intermolecular interactions. This review seeks to summarise current findings and understanding. [PUBLICATION ABSTRACT] |
Author | Nachtigallová, Dana Kleinermanns, Karl de Vries, Mattanjah S. |
Author_xml | – sequence: 1 givenname: Karl surname: Kleinermanns fullname: Kleinermanns, Karl organization: Institut für Physikalische Chemie und Elektrochemie, Heinrich Heine Universität Düsseldorf – sequence: 2 givenname: Dana surname: Nachtigallová fullname: Nachtigallová, Dana organization: The Institute of Organic Chemistry and Biochemistry – sequence: 3 givenname: Mattanjah S. surname: de Vries fullname: de Vries, Mattanjah S. email: devries@chem.ucsb.edu organization: Department of Chemistry and Biochemistry , University of California |
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Snippet | Biochemical reactions are subject to the particular environmental conditions of planet earth, including solar irradiation. How DNA responds to radiation is... |
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SubjectTerms | Biochemistry Chemical reactions computations conical intersections Deoxyribonucleic acid DNA DNA bases dynamics Environmental conditions excited state gas phase lifetime nucleobases |
Title | Excited state dynamics of DNA bases |
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