Excited state dynamics of DNA bases

Biochemical reactions are subject to the particular environmental conditions of planet earth, including solar irradiation. How DNA responds to radiation is relevant to human health because radiation damage can affect genetic propagation and lead to cancer and is also important for our understanding...

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Published inInternational reviews in physical chemistry Vol. 32; no. 2; pp. 308 - 342
Main Authors Kleinermanns, Karl, Nachtigallová, Dana, de Vries, Mattanjah S.
Format Journal Article
LanguageEnglish
Published Abingdon Routledge 01.06.2013
Taylor & Francis Ltd
Subjects
Biochemistry
Chemical reactions
computations
conical intersections
Deoxyribonucleic acid
DNA
DNA bases
dynamics
Environmental conditions
excited state
gas phase
lifetime
nucleobases
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Summary:Biochemical reactions are subject to the particular environmental conditions of planet earth, including solar irradiation. How DNA responds to radiation is relevant to human health because radiation damage can affect genetic propagation and lead to cancer and is also important for our understanding of how life on earth developed. A reductionist approach to unravelling the detailed photochemistry seeks to establish intrinsic properties of individual DNA building blocks, followed by extrapolation to larger systems, to incorporate interactions between the building blocks and the role of the biomolecular environment. Advances in both experimental and computational techniques have lead to increasingly detailed insights in the excited state dynamics of DNA bases in isolation as well as the role of the solvent and intermolecular interactions. This review seeks to summarise current findings and understanding.
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ISSN:0144-235X
1366-591X
DOI:10.1080/0144235X.2012.760884