Whitening Effect of Octaphlorethol A Isolated from Ishige foliacea in an In Vivo Zebrafish Model

• Published in: Journal of microbiology and biotechnology Vol. 25; no. 4; pp. 448 - 451
• Main Authors: Kim, Kil-Nam, Yang, Hye-Mi, Kang, Sung-Myung, Ahn, Ginnae, Roh, Seong Woon, Lee, WonWoo, Kim, Daekyung, Jeon, You-Jin
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국미생물·생명공학회 01.04.2015
• Subjects: Animals; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation - drug effects; Heart Rate - drug effects; Melanins - metabolism; Molecular Structure; Monophenol Monooxygenase - metabolism; Phaeophyceae - metabolism; Phenols - chemistry; Phenols - isolation & purification; Phenols - pharmacology; Zebrafish; 생물학

In a previous study, we isolated octaphlorethol A (OPA) from Ishige foliacea and evaluated its anti-melanogenesis activity in a murine melanoma cell line. However, the whitening effect and toxicity of OPA have not yet been examined in vivo. Therefore, in this study, we investigated the inhibitory ef...