Effects of fibrinogen and fibrin on the migration of vascular smooth muscle cells in vitro
The migration of vascular smooth muscle cells from the media into the intima and their proliferation in the intima play an important role in the pathogenesis of atherosclerosis. We examined the effects of fibrinogen and fibrin on the migration of cultured bovine aortic smooth muscle cells using a mo...
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| Published in | Atherosclerosis Vol. 83; no. 1; pp. 9 - 14 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
01.07.1990
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The migration of vascular smooth muscle cells from the media into the intima and their proliferation in the intima play an important role in the pathogenesis of atherosclerosis. We examined the effects of fibrinogen and fibrin on the migration of cultured bovine aortic smooth muscle cells using a modified Boyden chamber assay. The cells migrated to a gradient of soluble fibrinogen. Checkerboard analysis indicated that the effect was largely directional in nature (chemotaxis). The cells also migrated in a dose-dependent manner to a gradient of substrate-bound fibrinogen (haptotaxis). Fibrin, converted from substrate-bound fibrinogen by thrombin, also induced haptotaxis of smooth muscle cells. These observations suggest that, by recruiting smooth muscle cells from the media into the intima, fibrinogen and fibrin may be involved in the pathogenesis of arterial intimal thickening, atherosclerosis, and the organization of a thrombus. |
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| AbstractList | The migration of vascular smooth muscle cells from the media into the intima and their proliferation in the intima play an important role in the pathogenesis of atherosclerosis. We examined the effects of fibrinogen and fibrin on the migration of cultured bovine aortic smooth muscle cells using a modified Boyden chamber assay. The cells migrated to a gradient of soluble fibrinogen. Checkerboard analysis indicated that the effect was largely directional in nature (chemotaxis). The cells also migrated in a dose-dependent manner to a gradient of substrate-bound fibrinogen (haptotaxis). Fibrin, converted from substrate-bound fibrinogen by thrombin, also induced haptotaxis of smooth muscle cells. These observations suggest that, by recruiting smooth muscle cells from the media into the intima, fibrinogen and fibrin may be involved in the pathogenesis of arterial intimal thickening, atherosclerosis, and the organization of a thrombus.The migration of vascular smooth muscle cells from the media into the intima and their proliferation in the intima play an important role in the pathogenesis of atherosclerosis. We examined the effects of fibrinogen and fibrin on the migration of cultured bovine aortic smooth muscle cells using a modified Boyden chamber assay. The cells migrated to a gradient of soluble fibrinogen. Checkerboard analysis indicated that the effect was largely directional in nature (chemotaxis). The cells also migrated in a dose-dependent manner to a gradient of substrate-bound fibrinogen (haptotaxis). Fibrin, converted from substrate-bound fibrinogen by thrombin, also induced haptotaxis of smooth muscle cells. These observations suggest that, by recruiting smooth muscle cells from the media into the intima, fibrinogen and fibrin may be involved in the pathogenesis of arterial intimal thickening, atherosclerosis, and the organization of a thrombus. The migration of vascular smooth muscle cells from the media into the intima and their proliferation in the intima play an important role in the pathogenesis of atherosclerosis. We examined the effects of fibrinogen and fibrin on the migration of cultured bovine aortic smooth muscle cells using a modified Boyden chamber assay. The cells migrated to a gradient of soluble fibrinogen. Checkerboard analysis indicated that the effect was largely directional in nature (chemotaxis). The cells also migrated in a dose-dependent manner to a gradient of substrate-bound fibrinogen (haptotaxis). Fibrin, converted from substrate-bound fibrinogen by thrombin, also induced haptotaxis of smooth muscle cells. These observations suggest that, by recruiting smooth muscle cells from the media into the intima, fibrinogen and fibrin may be involved in the pathogenesis of arterial intimal thickening, atherosclerosis, and the organization of a thrombus. |
| Author | Naito, Michitaka Hayashi, Toshio Kuzuya, Masafumi Kuzuya, Fumio Funaki, Chiaki Asai, Kanichi |
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| Cites_doi | 10.1182/blood.V69.4.1038.1038 10.1093/oxfordjournals.bmb.a071483 10.1172/JCI110509 10.1016/S0308-2261(18)30021-3 10.1016/0021-9150(88)90178-5 10.1016/0021-9150(73)90078-6 10.1083/jcb.97.3.772 10.1016/0014-4827(89)90076-1 10.1016/0021-9150(72)90079-2 10.1056/NEJM197608192950805 10.1056/NEJM198602203140806 10.1002/path.1700600107 10.1161/01.ATV.9.1.109 10.1016/0021-9150(76)90116-7 10.1016/S0022-1759(80)80014-7 10.1016/0021-9150(89)90083-X 10.1111/j.1365-2141.1974.tb06633.x 10.1016/0033-0620(83)90006-3 10.1016/0021-9150(88)90038-X 10.1001/jama.1987.03400090067035 10.1056/NEJM197608122950707 10.1016/0021-9150(89)90013-0 10.1016/S0021-9258(18)50603-7 10.1056/NEJM198408233110804 10.1016/0014-5793(89)81370-5 10.1016/0021-9150(82)90111-3 10.1159/000229699 |
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| Keywords | Fibrin Haptotaxis Pathogenesis Atherosclerosis Fibrinogen Smooth muscle cells Chemotaxis Cell migration Bovine Cardiovascular disease Smooth muscle Glycoproteins Cell motility Vertebrata Mammalia Aorta Artiodactyla Mechanism of action Ungulata |
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| References | Bini, Fenoglio, Mesa-Tejada, Kudryk, Kaplan (BIB7) 1989; 9 Ross, Glomset (BIB1) 1976; 295 Smith, Slater, Hunter (BIB17) 1973; 18 Deuel, Senior, Huang, Griffin (BIB24) 1982; 69 Naito, Hayashi, Kuzuya, Funaki, Asai, Kuzuya (BIB9) 1989; 247 Fischer, Christensen (BIB19) 1988; 73 Kannel, Wolf, Castelh, D'Agostino (BIB21) 1987; 258 Wolhelmsen, Svardsudd, Koran-Bengtsen, Larsson, Welin, Tibblin (BIB20) 1984; 311 McConahey, Dixon (BIB12) 1966; 29 Bini, Fenoglio, Sobel, Owen, Fejgl, Kaplan (BIB18) 1987; 69 Ishida, Tanaka (BIB8) 1982; 44 Schainoff, Page (BIB15) 1972; 16 Kay, Pepper, McKenzie (BIB28) 1974; 27 Smith (BIB6) 1986; 15 Duguid (BIB14) 1948; 60 Allen, Browse, Rutt (BIB23) 1989; 77 Marguerie, Plow, Edgington (BIB13) 1979; 254 Ross (BIB3) 1986; 314 Handa, Kono, Saku, Sasaki, Kawano, Sasaki, Hiroki, Arakawa (BIB22) 1989; 77 Ross, Glomset (BIB2) 1976; 295 Woolf (BIB4) 1978; 34 McCarthy, Palm, Furcht (BIB11) 1983; 97 Naito, Hayashi, Fuanki, Kuzuya, Asai, Kuzuya (BIB26) 1988; 70 Kay, Pepper, Ewart (BIB27) 1973; 243 Smith, Alexander, Massie (BIB16) 1976; 23 Graves, Grotendorst, Antoniades, Schwartz, Valente (BIB25) 1989; 180 Niewiarowski, Rao (BIB5) 1983; 26 Falk, Goodwin, Leonard (BIB10) 1980; 33 Smith (10.1016/0021-9150(90)90124-2_BIB16) 1976; 23 Kannel (10.1016/0021-9150(90)90124-2_BIB21) 1987; 258 Ross (10.1016/0021-9150(90)90124-2_BIB1) 1976; 295 Ross (10.1016/0021-9150(90)90124-2_BIB3) 1986; 314 Deuel (10.1016/0021-9150(90)90124-2_BIB24) 1982; 69 Schainoff (10.1016/0021-9150(90)90124-2_BIB15) 1972; 16 Falk (10.1016/0021-9150(90)90124-2_BIB10) 1980; 33 Ross (10.1016/0021-9150(90)90124-2_BIB2) 1976; 295 Bini (10.1016/0021-9150(90)90124-2_BIB18) 1987; 69 Smith (10.1016/0021-9150(90)90124-2_BIB6) 1986; 15 Naito (10.1016/0021-9150(90)90124-2_BIB26) 1988; 70 Smith (10.1016/0021-9150(90)90124-2_BIB17) 1973; 18 Niewiarowski (10.1016/0021-9150(90)90124-2_BIB5) 1983; 26 Duguid (10.1016/0021-9150(90)90124-2_BIB14) 1948; 60 Woolf (10.1016/0021-9150(90)90124-2_BIB4) 1978; 34 Naito (10.1016/0021-9150(90)90124-2_BIB9) 1989; 247 Fischer (10.1016/0021-9150(90)90124-2_BIB19) 1988; 73 McConahey (10.1016/0021-9150(90)90124-2_BIB12) 1966; 29 Allen (10.1016/0021-9150(90)90124-2_BIB23) 1989; 77 McCarthy (10.1016/0021-9150(90)90124-2_BIB11) 1983; 97 Kay (10.1016/0021-9150(90)90124-2_BIB27) 1973; 243 Ishida (10.1016/0021-9150(90)90124-2_BIB8) 1982; 44 Handa (10.1016/0021-9150(90)90124-2_BIB22) 1989; 77 Graves (10.1016/0021-9150(90)90124-2_BIB25) 1989; 180 Bini (10.1016/0021-9150(90)90124-2_BIB7) 1989; 9 Marguerie (10.1016/0021-9150(90)90124-2_BIB13) 1979; 254 Kay (10.1016/0021-9150(90)90124-2_BIB28) 1974; 27 Wolhelmsen (10.1016/0021-9150(90)90124-2_BIB20) 1984; 311 |
| References_xml | – volume: 60 start-page: 57 year: 1948 ident: BIB14 article-title: Thrombi as a factor in the pathogenesis of coronary atherosclerosis publication-title: J. Pathol. Bacteriol. – volume: 44 start-page: 161 year: 1982 ident: BIB8 article-title: Effects of fibrin and fibrinogen-degradation products on the growth of rabbit aortic smooth muscle cells in culture publication-title: Atherosclerosis – volume: 33 start-page: 239 year: 1980 ident: BIB10 article-title: A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration publication-title: J. Immunol. Methods – volume: 73 start-page: 161 year: 1988 ident: BIB19 article-title: Immunohistochemical study of intimal protein deposits in the aging vascular wall of normo- and hypertensive patients publication-title: Atherosclerosis – volume: 69 start-page: 1046 year: 1982 ident: BIB24 article-title: Chemotaxis of monocytes and neutrophils to platelet-derived growth factor publication-title: J. Clin. Invest. – volume: 258 start-page: 1183 year: 1987 ident: BIB21 article-title: Fibrinogen and risk of cardiovascular disease. The Framingham Study publication-title: JAMA – volume: 23 start-page: 19 year: 1976 ident: BIB16 article-title: Insoluble “fibrin” in human aortic intima. Quantitation studies on the relationship between insoluble “fibrin”, soluble fibrinogen and low density lipoprotein publication-title: Atherosclerosis – volume: 34 start-page: 137 year: 1978 ident: BIB4 article-title: Thrombosis and atherosclerosis publication-title: Br. Med. Bull. – volume: 295 start-page: 369 year: 1976 ident: BIB1 article-title: The pathogenesis of atherosclerosis publication-title: N. Engl. J. Med. – volume: 254 start-page: 5357 year: 1979 ident: BIB13 article-title: Human platelets possess an inducible and saturable receptor specific for fibrinogen publication-title: J. Biol. Chem. – volume: 77 start-page: 209 year: 1989 ident: BIB22 article-title: Plasma fibrinogen levels as an independent indicator of severity of coronary atherosclerosis publication-title: Atherosclerosis – volume: 70 start-page: 273 year: 1988 ident: BIB26 article-title: Calcium antagonists do not inhibit vascular smooth muscle cell chemotaxis caused by platelet-derived growth factor publication-title: Atherosclerosis – volume: 243 start-page: 56 year: 1973 ident: BIB27 article-title: Generation of chemotactic activity for leukocytes by the action of thrombin on human fibrinogen publication-title: Nature – volume: 29 start-page: 185 year: 1966 ident: BIB12 article-title: A method of trace iodination of proteins for immunologic studies publication-title: Int. Arch. Allergy – volume: 77 start-page: 83 year: 1989 ident: BIB23 article-title: Effects of cigarette smoke, carbon monoxide and nicotine on the uptake of fibrinogen by the canine arterial wall publication-title: Atherosclerosis – volume: 18 start-page: 479 year: 1973 ident: BIB17 article-title: Quantitative studies on fibrinogen and low density lipoprotein in human aortic intima publication-title: Atherosclerosis – volume: 295 start-page: 420 year: 1976 ident: BIB2 article-title: The pathogenesis of atherosclerosis publication-title: N. Engl. J. Med. – volume: 180 start-page: 497 year: 1989 ident: BIB25 article-title: Platelet-derived growth factor is not chemotactic for human peripheral blood monocytes publication-title: Exp. Cell Res. – volume: 9 start-page: 109 year: 1989 ident: BIB7 article-title: Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies publication-title: Arteriosclerosis – volume: 311 start-page: 501 year: 1984 ident: BIB20 article-title: Fibrinogen as a risk factor for stroke and myocardial infarction publication-title: N. Engl. J. Med. – volume: 314 start-page: 488 year: 1986 ident: BIB3 article-title: The pathogenesis of atherosclerosis — an update publication-title: N. Engl. J. Med. – volume: 15 start-page: 355 year: 1986 ident: BIB6 article-title: Fbrinogen, fibrin and fibrin degradation products in relation to atherosclerosis publication-title: Clin. Haemato1. – volume: 69 start-page: 1038 year: 1987 ident: BIB18 article-title: Immunochemical characterization of fibrinogen, fibrin I, and fibrin II in human thrombi and atherosclerotic lesions publication-title: Blood – volume: 16 start-page: 287 year: 1972 ident: BIB15 article-title: Deposition of modified fibrinogen within the aortic intima publication-title: Atherosclerosis – volume: 26 start-page: 197 year: 1983 ident: BIB5 article-title: Contribution of thrombogenic factors to the pathogenesis of atherosclerosis publication-title: Prog. Cardiovasc. Dis. – volume: 27 start-page: 669 year: 1974 ident: BIB28 article-title: The identification of fibrinopeptide B as a chemotactic agent derived from human fibrinogen publication-title: Br. J. Haematol. – volume: 247 start-page: 358 year: 1989 ident: BIB9 article-title: Fibrinogen is chemotactic for vascular smooth muscle cells publication-title: FEBS Lett. – volume: 97 start-page: 772 year: 1983 ident: BIB11 article-title: Migration by haptotaxis of a Schwann cell tumor line to the basement membrane glycoprotein laminin publication-title: J. Cell Biol. – volume: 69 start-page: 1038 year: 1987 ident: 10.1016/0021-9150(90)90124-2_BIB18 article-title: Immunochemical characterization of fibrinogen, fibrin I, and fibrin II in human thrombi and atherosclerotic lesions publication-title: Blood doi: 10.1182/blood.V69.4.1038.1038 – volume: 34 start-page: 137 year: 1978 ident: 10.1016/0021-9150(90)90124-2_BIB4 article-title: Thrombosis and atherosclerosis publication-title: Br. Med. Bull. doi: 10.1093/oxfordjournals.bmb.a071483 – volume: 69 start-page: 1046 year: 1982 ident: 10.1016/0021-9150(90)90124-2_BIB24 article-title: Chemotaxis of monocytes and neutrophils to platelet-derived growth factor publication-title: J. Clin. Invest. doi: 10.1172/JCI110509 – volume: 15 start-page: 355 year: 1986 ident: 10.1016/0021-9150(90)90124-2_BIB6 article-title: Fbrinogen, fibrin and fibrin degradation products in relation to atherosclerosis publication-title: Clin. Haemato1. doi: 10.1016/S0308-2261(18)30021-3 – volume: 70 start-page: 273 year: 1988 ident: 10.1016/0021-9150(90)90124-2_BIB26 article-title: Calcium antagonists do not inhibit vascular smooth muscle cell chemotaxis caused by platelet-derived growth factor publication-title: Atherosclerosis doi: 10.1016/0021-9150(88)90178-5 – volume: 18 start-page: 479 year: 1973 ident: 10.1016/0021-9150(90)90124-2_BIB17 article-title: Quantitative studies on fibrinogen and low density lipoprotein in human aortic intima publication-title: Atherosclerosis doi: 10.1016/0021-9150(73)90078-6 – volume: 97 start-page: 772 year: 1983 ident: 10.1016/0021-9150(90)90124-2_BIB11 article-title: Migration by haptotaxis of a Schwann cell tumor line to the basement membrane glycoprotein laminin publication-title: J. Cell Biol. doi: 10.1083/jcb.97.3.772 – volume: 180 start-page: 497 year: 1989 ident: 10.1016/0021-9150(90)90124-2_BIB25 article-title: Platelet-derived growth factor is not chemotactic for human peripheral blood monocytes publication-title: Exp. Cell Res. doi: 10.1016/0014-4827(89)90076-1 – volume: 16 start-page: 287 year: 1972 ident: 10.1016/0021-9150(90)90124-2_BIB15 article-title: Deposition of modified fibrinogen within the aortic intima publication-title: Atherosclerosis doi: 10.1016/0021-9150(72)90079-2 – volume: 295 start-page: 420 year: 1976 ident: 10.1016/0021-9150(90)90124-2_BIB2 article-title: The pathogenesis of atherosclerosis publication-title: N. Engl. J. Med. doi: 10.1056/NEJM197608192950805 – volume: 314 start-page: 488 year: 1986 ident: 10.1016/0021-9150(90)90124-2_BIB3 article-title: The pathogenesis of atherosclerosis — an update publication-title: N. Engl. J. Med. doi: 10.1056/NEJM198602203140806 – volume: 60 start-page: 57 year: 1948 ident: 10.1016/0021-9150(90)90124-2_BIB14 article-title: Thrombi as a factor in the pathogenesis of coronary atherosclerosis publication-title: J. Pathol. Bacteriol. doi: 10.1002/path.1700600107 – volume: 9 start-page: 109 year: 1989 ident: 10.1016/0021-9150(90)90124-2_BIB7 article-title: Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies publication-title: Arteriosclerosis doi: 10.1161/01.ATV.9.1.109 – volume: 23 start-page: 19 year: 1976 ident: 10.1016/0021-9150(90)90124-2_BIB16 article-title: Insoluble “fibrin” in human aortic intima. Quantitation studies on the relationship between insoluble “fibrin”, soluble fibrinogen and low density lipoprotein publication-title: Atherosclerosis doi: 10.1016/0021-9150(76)90116-7 – volume: 33 start-page: 239 year: 1980 ident: 10.1016/0021-9150(90)90124-2_BIB10 article-title: A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration publication-title: J. Immunol. Methods doi: 10.1016/S0022-1759(80)80014-7 – volume: 77 start-page: 209 year: 1989 ident: 10.1016/0021-9150(90)90124-2_BIB22 article-title: Plasma fibrinogen levels as an independent indicator of severity of coronary atherosclerosis publication-title: Atherosclerosis doi: 10.1016/0021-9150(89)90083-X – volume: 27 start-page: 669 year: 1974 ident: 10.1016/0021-9150(90)90124-2_BIB28 article-title: The identification of fibrinopeptide B as a chemotactic agent derived from human fibrinogen publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.1974.tb06633.x – volume: 26 start-page: 197 year: 1983 ident: 10.1016/0021-9150(90)90124-2_BIB5 article-title: Contribution of thrombogenic factors to the pathogenesis of atherosclerosis publication-title: Prog. Cardiovasc. Dis. doi: 10.1016/0033-0620(83)90006-3 – volume: 73 start-page: 161 year: 1988 ident: 10.1016/0021-9150(90)90124-2_BIB19 article-title: Immunohistochemical study of intimal protein deposits in the aging vascular wall of normo- and hypertensive patients publication-title: Atherosclerosis doi: 10.1016/0021-9150(88)90038-X – volume: 258 start-page: 1183 year: 1987 ident: 10.1016/0021-9150(90)90124-2_BIB21 article-title: Fibrinogen and risk of cardiovascular disease. The Framingham Study publication-title: JAMA doi: 10.1001/jama.1987.03400090067035 – volume: 295 start-page: 369 year: 1976 ident: 10.1016/0021-9150(90)90124-2_BIB1 article-title: The pathogenesis of atherosclerosis publication-title: N. Engl. J. Med. doi: 10.1056/NEJM197608122950707 – volume: 77 start-page: 83 year: 1989 ident: 10.1016/0021-9150(90)90124-2_BIB23 article-title: Effects of cigarette smoke, carbon monoxide and nicotine on the uptake of fibrinogen by the canine arterial wall publication-title: Atherosclerosis doi: 10.1016/0021-9150(89)90013-0 – volume: 254 start-page: 5357 year: 1979 ident: 10.1016/0021-9150(90)90124-2_BIB13 article-title: Human platelets possess an inducible and saturable receptor specific for fibrinogen publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)50603-7 – volume: 311 start-page: 501 year: 1984 ident: 10.1016/0021-9150(90)90124-2_BIB20 article-title: Fibrinogen as a risk factor for stroke and myocardial infarction publication-title: N. Engl. J. Med. doi: 10.1056/NEJM198408233110804 – volume: 247 start-page: 358 year: 1989 ident: 10.1016/0021-9150(90)90124-2_BIB9 article-title: Fibrinogen is chemotactic for vascular smooth muscle cells publication-title: FEBS Lett. doi: 10.1016/0014-5793(89)81370-5 – volume: 243 start-page: 56 year: 1973 ident: 10.1016/0021-9150(90)90124-2_BIB27 article-title: Generation of chemotactic activity for leukocytes by the action of thrombin on human fibrinogen publication-title: Nature – volume: 44 start-page: 161 year: 1982 ident: 10.1016/0021-9150(90)90124-2_BIB8 article-title: Effects of fibrin and fibrinogen-degradation products on the growth of rabbit aortic smooth muscle cells in culture publication-title: Atherosclerosis doi: 10.1016/0021-9150(82)90111-3 – volume: 29 start-page: 185 year: 1966 ident: 10.1016/0021-9150(90)90124-2_BIB12 article-title: A method of trace iodination of proteins for immunologic studies publication-title: Int. Arch. Allergy doi: 10.1159/000229699 |
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| SubjectTerms | Animals Arteriosclerosis - etiology Atherosclerosis Biological and medical sciences Cattle Cell migration Cell Movement - physiology Cell physiology Cells, Cultured Chemotaxis Chemotaxis - physiology Fibrin Fibrin - pharmacology Fibrinogen Fibrinogen - pharmacology Fundamental and applied biological sciences. Psychology Haptotaxis Molecular and cellular biology Motility and taxis Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Pathogenesis Smooth muscle cells Thrombosis - etiology |
| Title | Effects of fibrinogen and fibrin on the migration of vascular smooth muscle cells in vitro |
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