Increased placental expression of Placental Protein 5 (PP5) / Tissue Factor Pathway Inhibitor-2 (TFPI-2) in women with preeclampsia and HELLP syndrome: Relevance to impaired trophoblast invasion?
Placental Protein 5 (PP5)/Tissue Factor Pathway Inhibitor-2 (TFPI-2) is an extracellular matrix-associated protein mainly expressed by the syncytiotrophoblast that may regulate trophoblast invasion. Our aim was to study placental PP5/TFPI-2 expression and its relation to placental pathology in vario...
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| Published in | Placenta (Eastbourne) Vol. 76; pp. 30 - 39 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Ltd
15.01.2019
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| Abstract | Placental Protein 5 (PP5)/Tissue Factor Pathway Inhibitor-2 (TFPI-2) is an extracellular matrix-associated protein mainly expressed by the syncytiotrophoblast that may regulate trophoblast invasion. Our aim was to study placental PP5/TFPI-2 expression and its relation to placental pathology in various forms of preeclampsia and HELLP syndrome.
Placental and maternal blood specimens were collected at the time of delivery from the same women in the following groups: 1) early controls; 2) early preeclampsia; 3) early preeclampsia with HELLP syndrome; 4) late controls; and 5) late preeclampsia. After histopathological examination, placental specimens were immunostained with polyclonal anti-PP5/TFPI-2 antibody on Western blot and tissue microarray immunohistochemistry. Placental PP5/TFPI-2 immunoscores were assessed manually and with a semi-automated method. Maternal sera were immunoassayed for PP5/TFPI-2.
PP5/TFPI-2 was localized to the cytoplasm of syncytiotrophoblast. Manual and semi-automated PP5/TFPI-2 immunoscores were higher in early preeclampsia with or without HELLP syndrome but not in late preeclampsia than in respective controls. In patients with preeclampsia, the correlation of placental PP5/TFPI-2 expression with maternal vascular malperfusion score of the placenta was positive while it was negative with birthweight and placental weight. Maternal serum PP5/TFPI-2 concentration was higher in early preeclampsia and it tended to be higher in early preeclampsia with HELLP syndrome than in early controls.
Our findings suggest that an increased placental PP5/TFPI-2 expression may be associated with abnormal placentation in early preeclampsia, with or without HELLP syndrome.
•PP5/TFPI-2 is predominantly produced in large amounts by the placenta.•PP5/TFPI-2 is mainly expressed by the syncytiotrophoblast.•Placental PP5/TFPI-2 expression is increased in early- but not late preeclampsia.•Maternal serum PP5/TFPI-2 is increased in early- but not late preeclampsia.•Placental PP5/TFPI-2 correlates with maternal vascular malperfusion of the placenta. |
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| AbstractList | Placental Protein 5 (PP5)/Tissue Factor Pathway Inhibitor-2 (TFPI-2) is an extracellular matrix-associated protein mainly expressed by the syncytiotrophoblast that may regulate trophoblast invasion. Our aim was to study placental PP5/TFPI-2 expression and its relation to placental pathology in various forms of preeclampsia and HELLP syndrome.
Placental and maternal blood specimens were collected at the time of delivery from the same women in the following groups: 1) early controls; 2) early preeclampsia; 3) early preeclampsia with HELLP syndrome; 4) late controls; and 5) late preeclampsia. After histopathological examination, placental specimens were immunostained with polyclonal anti-PP5/TFPI-2 antibody on Western blot and tissue microarray immunohistochemistry. Placental PP5/TFPI-2 immunoscores were assessed manually and with a semi-automated method. Maternal sera were immunoassayed for PP5/TFPI-2.
PP5/TFPI-2 was localized to the cytoplasm of syncytiotrophoblast. Manual and semi-automated PP5/TFPI-2 immunoscores were higher in early preeclampsia with or without HELLP syndrome but not in late preeclampsia than in respective controls. In patients with preeclampsia, the correlation of placental PP5/TFPI-2 expression with maternal vascular malperfusion score of the placenta was positive while it was negative with birthweight and placental weight. Maternal serum PP5/TFPI-2 concentration was higher in early preeclampsia and it tended to be higher in early preeclampsia with HELLP syndrome than in early controls.
Our findings suggest that an increased placental PP5/TFPI-2 expression may be associated with abnormal placentation in early preeclampsia, with or without HELLP syndrome.
•PP5/TFPI-2 is predominantly produced in large amounts by the placenta.•PP5/TFPI-2 is mainly expressed by the syncytiotrophoblast.•Placental PP5/TFPI-2 expression is increased in early- but not late preeclampsia.•Maternal serum PP5/TFPI-2 is increased in early- but not late preeclampsia.•Placental PP5/TFPI-2 correlates with maternal vascular malperfusion of the placenta. Placental Protein 5 (PP5)/Tissue Factor Pathway Inhibitor-2 (TFPI-2) is an extracellular matrix-associated protein mainly expressed by the syncytiotrophoblast that may regulate trophoblast invasion. Our aim was to study placental PP5/TFPI-2 expression and its relation to placental pathology in various forms of preeclampsia and HELLP syndrome. Placental and maternal blood specimens were collected at the time of delivery from the same women in the following groups: 1) early controls; 2) early preeclampsia; 3) early preeclampsia with HELLP syndrome; 4) late controls; and 5) late preeclampsia. After histopathological examination, placental specimens were immunostained with polyclonal anti-PP5/TFPI-2 antibody on Western blot and tissue microarray immunohistochemistry. Placental PP5/TFPI-2 immunoscores were assessed manually and with a semi-automated method. Maternal sera were immunoassayed for PP5/TFPI-2. PP5/TFPI-2 was localized to the cytoplasm of syncytiotrophoblast. Manual and semi-automated PP5/TFPI-2 immunoscores were higher in early preeclampsia with or without HELLP syndrome but not in late preeclampsia than in respective controls. In patients with preeclampsia, the correlation of placental PP5/TFPI-2 expression with maternal vascular malperfusion score of the placenta was positive while it was negative with birthweight and placental weight. Maternal serum PP5/TFPI-2 concentration was higher in early preeclampsia and it tended to be higher in early preeclampsia with HELLP syndrome than in early controls. Our findings suggest that an increased placental PP5/TFPI-2 expression may be associated with abnormal placentation in early preeclampsia, with or without HELLP syndrome. INTRODUCTIONPlacental Protein 5 (PP5)/Tissue Factor Pathway Inhibitor-2 (TFPI-2) is an extracellular matrix-associated protein mainly expressed by the syncytiotrophoblast that may regulate trophoblast invasion. Our aim was to study placental PP5/TFPI-2 expression and its relation to placental pathology in various forms of preeclampsia and HELLP syndrome. METHODSPlacental and maternal blood specimens were collected at the time of delivery from the same women in the following groups: 1) early controls; 2) early preeclampsia; 3) early preeclampsia with HELLP syndrome; 4) late controls; and 5) late preeclampsia. After histopathological examination, placental specimens were immunostained with polyclonal anti-PP5/TFPI-2 antibody on Western blot and tissue microarray immunohistochemistry. Placental PP5/TFPI-2 immunoscores were assessed manually and with a semi-automated method. Maternal sera were immunoassayed for PP5/TFPI-2. RESULTSPP5/TFPI-2 was localized to the cytoplasm of syncytiotrophoblast. Manual and semi-automated PP5/TFPI-2 immunoscores were higher in early preeclampsia with or without HELLP syndrome but not in late preeclampsia than in respective controls. In patients with preeclampsia, the correlation of placental PP5/TFPI-2 expression with maternal vascular malperfusion score of the placenta was positive while it was negative with birthweight and placental weight. Maternal serum PP5/TFPI-2 concentration was higher in early preeclampsia and it tended to be higher in early preeclampsia with HELLP syndrome than in early controls. DISCUSSIONOur findings suggest that an increased placental PP5/TFPI-2 expression may be associated with abnormal placentation in early preeclampsia, with or without HELLP syndrome. |
| Author | Kiraly, Peter Kocsis-Deak, Barbara Kovalszky, Ilona Papp, Zoltan Than, Nandor Gabor Krenacs, Tibor Hupuczi, Petronella Hargitai, Beata Erez, Offer Karaszi, Katalin Szabo, Szilvia Juhasz, Kata |
| Author_xml | – sequence: 1 givenname: Katalin orcidid: 0000-0002-9188-1987 surname: Karaszi fullname: Karaszi, Katalin organization: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary – sequence: 2 givenname: Szilvia surname: Szabo fullname: Szabo, Szilvia organization: Systems Biology of Reproduction Lendulet Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary – sequence: 3 givenname: Kata surname: Juhasz fullname: Juhasz, Kata organization: Systems Biology of Reproduction Lendulet Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary – sequence: 4 givenname: Peter surname: Kiraly fullname: Kiraly, Peter organization: Systems Biology of Reproduction Lendulet Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary – sequence: 5 givenname: Barbara surname: Kocsis-Deak fullname: Kocsis-Deak, Barbara organization: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary – sequence: 6 givenname: Beata surname: Hargitai fullname: Hargitai, Beata organization: West Midlands Perinatal Pathology Centre, Cellular Pathology Department, Birmingham Women's and Children's NHS FT, Birmingham, United Kingdom – sequence: 7 givenname: Tibor surname: Krenacs fullname: Krenacs, Tibor organization: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary – sequence: 8 givenname: Petronella surname: Hupuczi fullname: Hupuczi, Petronella organization: Maternity Private Department, Kutvolgyi Clinical Block, Semmelweis University, Budapest, Hungary – sequence: 9 givenname: Offer surname: Erez fullname: Erez, Offer organization: Maternity Department "D" Division of Obstetrics and Gynecology, Soroka University Medical Center, School of Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel – sequence: 10 givenname: Zoltan surname: Papp fullname: Papp, Zoltan organization: Maternity Private Department, Kutvolgyi Clinical Block, Semmelweis University, Budapest, Hungary – sequence: 11 givenname: Ilona surname: Kovalszky fullname: Kovalszky, Ilona organization: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary – sequence: 12 givenname: Nandor Gabor surname: Than fullname: Than, Nandor Gabor email: than.gabor@ttk.mta.hu organization: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30803712$$D View this record in MEDLINE/PubMed |
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| Keywords | Pregnancy Trophoblast Placenta Invasion Coagulation |
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| SubjectTerms | Adult Case-Control Studies Coagulation Female Glycoproteins - metabolism HELLP Syndrome - metabolism HELLP Syndrome - pathology Humans Invasion Placenta Placenta - metabolism Placenta - pathology Placentation Pre-Eclampsia - metabolism Pre-Eclampsia - pathology Pregnancy Trophoblast |
| Title | Increased placental expression of Placental Protein 5 (PP5) / Tissue Factor Pathway Inhibitor-2 (TFPI-2) in women with preeclampsia and HELLP syndrome: Relevance to impaired trophoblast invasion? |
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