Prevention of Amyloidosis in Familial Mediterranean Fever with Colchicine: A Case-Control Study in Armenia

• Published in: Medical principles and practice Vol. 18; no. 6; pp. 441 - 446
• Main Authors: Sevoyan, Maria K., Sarkisian, Tamara F., Beglaryan, Ara A., Shahsuvaryan, Gohar R., Armenian, Haroutune K.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2009
• Subjects: Adult; Age Factors; Amyloidosis - etiology; Amyloidosis - prevention & control; Armenia; Case-Control Studies; Colchicine - administration & dosage; Cytoskeletal Proteins - genetics; Dose-Response Relationship, Drug; Drug Administration Schedule; Familial Mediterranean Fever - complications; Familial Mediterranean Fever - drug therapy; Familial Mediterranean Fever - genetics; Female; Humans; Male; Middle Aged; Mutation; Odds Ratio; Original Paper; Pyrin; Tubulin Modulators - administration & dosage; Young Adult; Familial Mediterranean fever, case-control study; Amyloidosis; Colchicine

Objective: To determine whether or not the use of colchicine decreases the risk of amyloidosis among Armenian patients with familial Mediterranean fever (FMF). Subjects and Methods: The study included 99 Armenian patients from the Center of Medical Genetics database with genetically ascertained FMF;...