Making heads or tails of shattered chromosomes
Isolation of lagging chromosomes in micronuclei causes catastrophic genome rearrangements The human genome is subject to continuous change as a result of spontaneous DNA mutation. Most of the genetic changes are harmless, but occasionally they can disturb normal cell functioning and lead to cancer o...
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| Published in | Science (American Association for the Advancement of Science) Vol. 348; no. 6240; pp. 1205 - 1206 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Washington
The American Association for the Advancement of Science
12.06.2015
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| Subjects | |
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| Abstract | Isolation of lagging chromosomes in micronuclei causes catastrophic genome rearrangements
The human genome is subject to continuous change as a result of spontaneous DNA mutation. Most of the genetic changes are harmless, but occasionally they can disturb normal cell functioning and lead to cancer or congenital diseases. Much of the novel genetic variation that arises in human genomes affects only one or a few nucleotides. However, catastrophic changes of genome structure, termed chromothripsis, can produce a dramatic reorganization of DNA on one or even several chromosomes. A recent study by Zhang
et al.
(
1
) has now revealed a molecular mechanism that causes chromothripsis. |
|---|---|
| AbstractList | Isolation of lagging chromosomes in micronuclei causes catastrophic genome rearrangements
The human genome is subject to continuous change as a result of spontaneous DNA mutation. Most of the genetic changes are harmless, but occasionally they can disturb normal cell functioning and lead to cancer or congenital diseases. Much of the novel genetic variation that arises in human genomes affects only one or a few nucleotides. However, catastrophic changes of genome structure, termed chromothripsis, can produce a dramatic reorganization of DNA on one or even several chromosomes. A recent study by Zhang
et al.
(
1
) has now revealed a molecular mechanism that causes chromothripsis. The human genome is subject to continuous change as a result of spontaneous DNA mutation. Most of the genetic changes are harmless, but occasionally they can disturb normal cell functioning and lead to cancer or congenital diseases. Much of the novel genetic variation that arises in human genomes affects only one or a few nucleotides. However, catastrophic changes of genome structure, termed chromothripsis, can produce a dramatic reorganization of DNA on one or even several chromosomes. A recent study by Zhang et al. (1) has now revealed a molecular mechanism that causes chromothripsis. The human genome is subject to continuous change as a result of spontaneous DNA mutation. Most of the genetic changes are harmless, but occasionally they can disturb normal cell functioning and lead to cancer or congenital diseases. Much of the novel genetic variation that arises in human genomes affects only one or a few nucleotides. However, catastrophic changes of genome structure, termed chromothripsis, can produce a dramatic reorganization of DNA on one or even several chromosomes. A recent study by Zhang et al. has now revealed a molecular mechanism that causes chromothripsis. |
| Author | Kloosterman, Wigard P. |
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| Cites_doi | 10.1016/j.cell.2011.12.013 10.1016/j.cell.2010.11.055 10.1016/j.cell.2013.06.007 10.1093/hmg/ddr073 10.1016/j.cell.2011.07.042 10.1016/j.cell.2013.02.023 10.1038/nature10802 10.1038/nm.2988 |
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| DOI | 10.1126/science.aac5277 |
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| References | Korbel J. O. (e_1_3_1_6_2) 2013; 152 e_1_3_1_8_2 Rausch T. (e_1_3_1_10_2) 2012; 148 Hatch E. M. (e_1_3_1_9_2) 2013; 154 e_1_3_1_3_2 Kloosterman W. P. (e_1_3_1_4_2) 2011; 20 Holland A. J. (e_1_3_1_5_2) 2012; 18 e_1_3_1_2_2 Liu P. (e_1_3_1_7_2) 2011; 146 |
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| Snippet | Isolation of lagging chromosomes in micronuclei causes catastrophic genome rearrangements
The human genome is subject to continuous change as a result of... The human genome is subject to continuous change as a result of spontaneous DNA mutation. Most of the genetic changes are harmless, but occasionally they can... |
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| SubjectTerms | Cancer Chromosomes congenital abnormalities Deoxyribonucleic acid DNA Genetic diversity genetic variation Genetics genome Genomes Genomics humans Molecular biology Molecular structure Mutation Mutations neoplasms Nucleotides |
| Title | Making heads or tails of shattered chromosomes |
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