Key virulence factors responsible for differences in pathogenicity between clinically proven live-attenuated Japanese encephalitis vaccine SA14-14-2 and its pre-attenuated highly virulent parent SA14

• Published in: PLoS pathogens Vol. 21; no. 1; p. e1012844
• Main Authors: Song, Byung-Hak, Yun, Sang-Im, Goldhardt, Joseph L., Kim, Jiyoun, Lee, Young-Min
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science (PLoS) 01.01.2025
• Subjects: Animals; Encephalitis Virus, Japanese - genetics; Encephalitis Virus, Japanese - immunology; Encephalitis Virus, Japanese - pathogenicity; Encephalitis, Japanese - immunology; Encephalitis, Japanese - prevention & control; Encephalitis, Japanese - virology; Female; Humans; Japanese Encephalitis Vaccines - genetics; Japanese Encephalitis Vaccines - immunology; Mice; Vaccines, Attenuated - genetics; Vaccines, Attenuated - immunology; Viral Envelope Proteins - genetics; Viral Envelope Proteins - immunology; Virulence; Virulence Factors - genetics; Virulence Factors - immunology; Virulence Factors - metabolism; Virus Replication

Japanese encephalitis virus (JEV), a neuroinvasive and neurovirulent orthoflavivirus, can be prevented in humans with the SA 14 -14-2 vaccine, a live-attenuated version derived from the wild-type SA 14 strain. To determine the viral factors responsible for the differences in pathogenicity between SA...