Diversity-oriented synthesis: producing chemical tools for dissecting biology

• Published in: Chemical Society reviews Vol. 41; no. 12; pp. 4444 - 4456
• Main Authors: O' Connor, Cornelius J, Beckmann, Henning S. G, Spring, David R
• Format: Journal Article
• Language: English
• Published: England 28.05.2012
• Subjects: Animals; Biochemistry - methods; Drug Discovery - methods; functional diversity; human diseases; Humans; Mice; Models, Biological; Models, Molecular; Pharmaceutical Preparations - chemistry; Proteins - chemistry; screening; Small Molecule Libraries

Small molecule modulators of biological function can be discovered by the screening of compound libraries. However, it became apparent that some human disease related targets could not be addressed by the libraries commonly used which typically are comprised of large numbers of structurally similar...