Bioengineered tooth emulation systems for regenerative and pharmacological purposes

• Published in: European cells & materials Vol. 41; pp. 502 - 516
• Main Authors: Pagella, P, Cordiale, A, Marconi, G D, Trubiani, O, Rasponi, M, Mitsiadis, T A
• Format: Journal Article
• Language: English
• Published: Switzerland Forum Multimedia Publishing LLC 10.05.2021
• Subjects: Animals; bioreactors; dental pulp stem cells; drug discovery; Humans; Mesenchymal Stem Cells - physiology; microfluidics; organ-on-a-chip; periodontal ligament stem cells; regeneration; Regeneration - physiology; stem cells; Tissue Engineering - methods; tooth; Tooth - physiology

Genetic conditions, traumatic injuries, carious lesions and periodontal diseases are all responsible for dental pathologies. The current clinical approaches are based on the substitution of damaged dental tissues with inert materials, which, however, do not ensure full physiological recovery of the...