Lipopolysaccharide induced neuroprotective effects of bacterial protease against Alzheimer's disease in male Wistar albino rats

• Published in: International journal of biological macromolecules Vol. 230; p. 123260
• Main Authors: Azzam, Shaimaa M., Abdel Rahman, Amina A.S., Ahmed-Farid, Omar A., Abu El-Wafa, Wael Mohamed, Salem, Gad Elsayed Mohamed
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2023
• Subjects: Acetylcholinesterase - metabolism; Alzheimer Disease - metabolism; Alzheimer's disease (AD); Animals; Bacillus cereus; Disease Models, Animal; Donepezil; Endopeptidases - metabolism; Hippocampus - metabolism; Lipopolysaccharides (LPS); Lipopolysaccharides - pharmacology; Male; Maze Learning; Memory Disorders - drug therapy; Neuroprotective Agents - therapeutic use; p-Tau protein; Peptide Hydrolases - metabolism; Protease; Rats; Rats, Wistar; Alzheimer's disease (AD); p-Tau protein; Bacillus cereus; Lipopolysaccharides (LPS); Protease; Donepezil

Alzheimer's disease (AD) is a highly severe neurodegenerative condition that affects the hippocampus and is characterized by memory loss and dementia. This investigation aims to determine the potential of a bacterial protease enzyme produced by a new mutant strain of bacteria (Bacillus cereus S...