Lactoferrin coated or conjugated nanomaterials as an active targeting approach in nanomedicine

• Published in: International journal of biological macromolecules Vol. 167; pp. 1527 - 1543
• Main Authors: Agwa, Mona M., Sabra, Sally
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2021
• Subjects: Active targeting; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Cancer; Coated nanocarriers; Dendrimers - chemistry; Drug Carriers - metabolism; Drug Liberation; Humans; Lactoferrin; Lactoferrin - chemistry; Lactoferrin - metabolism; Liposomes - chemistry; Liposomes - metabolism; Magnetite Nanoparticles - chemistry; Nanomedicine - methods; Nanoparticles - chemistry; Nanoparticles - metabolism; Nanostructures - chemistry; Neoplasms - drug therapy; Neoplasms - metabolism; Neurodegenerative diseases; Receptors, Transferrin - metabolism; Transferrin - metabolism; Active targeting; Lactoferrin; Coated nanocarriers; Neurodegenerative diseases; Cancer

A successful drug delivery to a specific site relies on two essential factors including; efficient entrapment of the drug within the carrier and successful delivery of drug- loaded nanocarrier to the target site without opsonisation or drug release in the circulation before reaching the organ of int...