Lactoferrin coated or conjugated nanomaterials as an active targeting approach in nanomedicine
A successful drug delivery to a specific site relies on two essential factors including; efficient entrapment of the drug within the carrier and successful delivery of drug- loaded nanocarrier to the target site without opsonisation or drug release in the circulation before reaching the organ of int...
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| Published in | International journal of biological macromolecules Vol. 167; pp. 1527 - 1543 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
15.01.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | A successful drug delivery to a specific site relies on two essential factors including; efficient entrapment of the drug within the carrier and successful delivery of drug- loaded nanocarrier to the target site without opsonisation or drug release in the circulation before reaching the organ of interest. Lactoferrin (LF) is a glycoprotein belonging to the transferrin (TF) family which can bind to TF receptors (TFRs) and LF membrane internalization receptors (LFRs) highly expressed on the cell surface of both highly proliferating cancer cells and blood brain barrier (BBB), which in turn can facilitate its accessibility to the cell nucleus. This merit could be exploited to develop actively targeted drug delivery systems that can easily cross the BBB or internalize into tumor cells. In this review, the most recent advances of utilizing LF as an active targeting ligand for different types of nanocarriers including: inorganic nanoparticles, dendrimers, synthetic biodegradable polymers, lipid nanocarriers, natural polymers, and nanoemulstions will be highlighted. Collectively, LF seems to be a promising targeting ligand in the field of nanomedicine.
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| AbstractList | A successful drug delivery to a specific site relies on two essential factors including; efficient entrapment of the drug within the carrier and successful delivery of drug- loaded nanocarrier to the target site without opsonisation or drug release in the circulation before reaching the organ of interest. Lactoferrin (LF) is a glycoprotein belonging to the transferrin (TF) family which can bind to TF receptors (TFRs) and LF membrane internalization receptors (LFRs) highly expressed on the cell surface of both highly proliferating cancer cells and blood brain barrier (BBB), which in turn can facilitate its accessibility to the cell nucleus. This merit could be exploited to develop actively targeted drug delivery systems that can easily cross the BBB or internalize into tumor cells. In this review, the most recent advances of utilizing LF as an active targeting ligand for different types of nanocarriers including: inorganic nanoparticles, dendrimers, synthetic biodegradable polymers, lipid nanocarriers, natural polymers, and nanoemulstions will be highlighted. Collectively, LF seems to be a promising targeting ligand in the field of nanomedicine. A successful drug delivery to a specific site relies on two essential factors including; efficient entrapment of the drug within the carrier and successful delivery of drug- loaded nanocarrier to the target site without opsonisation or drug release in the circulation before reaching the organ of interest. Lactoferrin (LF) is a glycoprotein belonging to the transferrin (TF) family which can bind to TF receptors (TFRs) and LF membrane internalization receptors (LFRs) highly expressed on the cell surface of both highly proliferating cancer cells and blood brain barrier (BBB), which in turn can facilitate its accessibility to the cell nucleus. This merit could be exploited to develop actively targeted drug delivery systems that can easily cross the BBB or internalize into tumor cells. In this review, the most recent advances of utilizing LF as an active targeting ligand for different types of nanocarriers including: inorganic nanoparticles, dendrimers, synthetic biodegradable polymers, lipid nanocarriers, natural polymers, and nanoemulstions will be highlighted. Collectively, LF seems to be a promising targeting ligand in the field of nanomedicine. [Display omitted] |
| Author | Sabra, Sally Agwa, Mona M. |
| Author_xml | – sequence: 1 givenname: Mona M. surname: Agwa fullname: Agwa, Mona M. email: mona.m.agwa@alexu.edu.eg, magwa79@gmail.com organization: Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Giza 12311, Egypt – sequence: 2 givenname: Sally surname: Sabra fullname: Sabra, Sally email: ssabra@uwo.ca, igsr.ssabra@alexu.edu.eg organization: Department of Biotechnology, Institute of Graduate studies and Research, Alexandria University, Alexandria 21526, Egypt |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33212102$$D View this record in MEDLINE/PubMed |
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| Keywords | Active targeting Lactoferrin Coated nanocarriers Neurodegenerative diseases Cancer |
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| SubjectTerms | Active targeting Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Cancer Coated nanocarriers Dendrimers - chemistry Drug Carriers - metabolism Drug Liberation Humans Lactoferrin Lactoferrin - chemistry Lactoferrin - metabolism Liposomes - chemistry Liposomes - metabolism Magnetite Nanoparticles - chemistry Nanomedicine - methods Nanoparticles - chemistry Nanoparticles - metabolism Nanostructures - chemistry Neoplasms - drug therapy Neoplasms - metabolism Neurodegenerative diseases Receptors, Transferrin - metabolism Transferrin - metabolism |
| Title | Lactoferrin coated or conjugated nanomaterials as an active targeting approach in nanomedicine |
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