In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs

• Published in: Analytical chemistry (Washington) Vol. 92; no. 12; pp. 8010 - 8014
• Main Authors: Vaneev, Alexander N., Gorelkin, Petr V., Garanina, Anastasiia S., Lopatukhina, Helena V., Vodopyanov, Stepan S., Alova, Anna V., Ryabaya, Oxana O., Akasov, Roman A., Zhang, Yanjun, Novak, Pavel, Salikhov, Sergey V., Abakumov, Maxim A., Takahashi, Yasufumi, Edwards, Christopher R. W., Klyachko, Natalia L., Majouga, Alexander G., Korchev, Yuri E., Erofeev, Alexander S.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 16.06.2020
• Subjects: Analytical chemistry; Animals; Antineoplastic Agents - pharmacology; Antineoplastic drugs; Antitumor agents; Biosensing Techniques; Cancer; cancer therapy; Cell Line, Tumor; Chemistry; Chemotherapy; Doxorubicin; Doxorubicin - pharmacology; Drug development; drug therapy; Drugs; Electrochemical Techniques; Electrochemistry; Humans; Intracellular; mechanism of action; Mice; neoplasms; Neoplasms, Experimental - diagnosis; Neoplasms, Experimental - drug therapy; Neoplasms, Experimental - metabolism; PC-3 Cells; Reactive oxygen species; Reactive Oxygen Species - analysis; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Tumors

monitoring of reactive oxygen species (ROS) in tumors during treatment with anticancer therapy is important for understanding the mechanism of action and in the design of new anticancer drugs. In this work, a platinized nanoelectrode is placed into a single cell for detection of the ROS signal, and...