In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs
monitoring of reactive oxygen species (ROS) in tumors during treatment with anticancer therapy is important for understanding the mechanism of action and in the design of new anticancer drugs. In this work, a platinized nanoelectrode is placed into a single cell for detection of the ROS signal, and...
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| Published in | Analytical chemistry (Washington) Vol. 92; no. 12; pp. 8010 - 8014 |
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| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
16.06.2020
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| Abstract | monitoring of reactive oxygen species (ROS) in tumors during treatment with anticancer therapy is important for understanding the mechanism of action and in the design of new anticancer drugs. In this work, a platinized nanoelectrode is placed into a single cell for detection of the ROS signal, and drug-induced ROS production is then recorded. The main advantages of this method are the short incubation time with the drug and its high sensitivity which allows the detection of low intracellular ROS concentrations. We have shown that our new method can measure the ROS response to chemotherapy in tumor-bearing mice in real-time. ROS levels were measured
inside the tumor at different depths in response to doxorubicin. This work provides an effective new approach for the measurement of intracellular ROS by platinized nanoelectrodes. |
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| AbstractList | In vivo monitoring of reactive oxygen species (ROS) in tumors during treatment with anticancer therapy is important for understanding the mechanism of action and in the design of new anticancer drugs. In this work, a platinized nanoelectrode is placed into a single cell for detection of the ROS signal, and drug-induced ROS production is then recorded. The main advantages of this method are the short incubation time with the drug and its high sensitivity which allows the detection of low intracellular ROS concentrations. We have shown that our new method can measure the ROS response to chemotherapy in tumor-bearing mice in real-time. ROS levels were measured in vivo inside the tumor at different depths in response to doxorubicin. This work provides an effective new approach for the measurement of intracellular ROS by platinized nanoelectrodes. In vivo monitoring of reactive oxygen species (ROS) in tumors during treatment with anticancer therapy is important for understanding the mechanism of action and in the design of new anticancer drugs. In this work, a platinized nanoelectrode is placed into a single cell for detection of the ROS signal, and drug-induced ROS production is then recorded. The main advantages of this method are the short incubation time with the drug and its high sensitivity which allows the detection of low intracellular ROS concentrations. We have shown that our new method can measure the ROS response to chemotherapy in tumor-bearing mice in real-time. ROS levels were measured in vivo inside the tumor at different depths in response to doxorubicin. This work provides an effective new approach for the measurement of intracellular ROS by platinized nanoelectrodes.In vivo monitoring of reactive oxygen species (ROS) in tumors during treatment with anticancer therapy is important for understanding the mechanism of action and in the design of new anticancer drugs. In this work, a platinized nanoelectrode is placed into a single cell for detection of the ROS signal, and drug-induced ROS production is then recorded. The main advantages of this method are the short incubation time with the drug and its high sensitivity which allows the detection of low intracellular ROS concentrations. We have shown that our new method can measure the ROS response to chemotherapy in tumor-bearing mice in real-time. ROS levels were measured in vivo inside the tumor at different depths in response to doxorubicin. This work provides an effective new approach for the measurement of intracellular ROS by platinized nanoelectrodes. monitoring of reactive oxygen species (ROS) in tumors during treatment with anticancer therapy is important for understanding the mechanism of action and in the design of new anticancer drugs. In this work, a platinized nanoelectrode is placed into a single cell for detection of the ROS signal, and drug-induced ROS production is then recorded. The main advantages of this method are the short incubation time with the drug and its high sensitivity which allows the detection of low intracellular ROS concentrations. We have shown that our new method can measure the ROS response to chemotherapy in tumor-bearing mice in real-time. ROS levels were measured inside the tumor at different depths in response to doxorubicin. This work provides an effective new approach for the measurement of intracellular ROS by platinized nanoelectrodes. |
| Author | Korchev, Yuri E. Zhang, Yanjun Abakumov, Maxim A. Takahashi, Yasufumi Edwards, Christopher R. W. Lopatukhina, Helena V. Akasov, Roman A. Ryabaya, Oxana O. Majouga, Alexander G. Novak, Pavel Garanina, Anastasiia S. Salikhov, Sergey V. Erofeev, Alexander S. Gorelkin, Petr V. Vodopyanov, Stepan S. Klyachko, Natalia L. Vaneev, Alexander N. Alova, Anna V. |
| Author_xml | – sequence: 1 givenname: Alexander N. orcidid: 0000-0001-8201-8498 surname: Vaneev fullname: Vaneev, Alexander N. organization: National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia, Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, 1, 3, Moscow 119991, Russia – sequence: 2 givenname: Petr V. surname: Gorelkin fullname: Gorelkin, Petr V. organization: National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia – sequence: 3 givenname: Anastasiia S. surname: Garanina fullname: Garanina, Anastasiia S. organization: National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia – sequence: 4 givenname: Helena V. surname: Lopatukhina fullname: Lopatukhina, Helena V. organization: Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, 1, 3, Moscow 119991, Russia – sequence: 5 givenname: Stepan S. surname: Vodopyanov fullname: Vodopyanov, Stepan S. organization: National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia, Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, 1, 3, Moscow 119991, Russia – sequence: 6 givenname: Anna V. surname: Alova fullname: Alova, Anna V. organization: National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia, Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, 1, 3, Moscow 119991, Russia – sequence: 7 givenname: Oxana O. surname: Ryabaya fullname: Ryabaya, Oxana O. organization: N. N. Blokhin National Medical Research Center of Oncology, 24 Kashirskoe shosse, Moscow 115478, Russia – sequence: 8 givenname: Roman A. surname: Akasov fullname: Akasov, Roman A. organization: National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia, I. M. Sechenov First Moscow State Medical University, Trubetskaya Str. 8-2, Moscow 119991, Russia – sequence: 9 givenname: Yanjun surname: Zhang fullname: Zhang, Yanjun organization: Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China, Imperial College London, Department of Medicine, London W12 0NN, United Kingdom – sequence: 10 givenname: Pavel surname: Novak fullname: Novak, Pavel organization: National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia, Imperial College London, Department of Medicine, London W12 0NN, United Kingdom – sequence: 11 givenname: Sergey V. surname: Salikhov fullname: Salikhov, Sergey V. organization: National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia – sequence: 12 givenname: Maxim A. surname: Abakumov fullname: Abakumov, Maxim A. organization: N. I. Pirogov Russian National Research Medical University, Ostrovityanova Street 1/7, Moscow 117997, Russia – sequence: 13 givenname: Yasufumi orcidid: 0000-0003-2834-8300 surname: Takahashi fullname: Takahashi, Yasufumi organization: Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan – sequence: 14 givenname: Christopher R. W. surname: Edwards fullname: Edwards, Christopher R. W. organization: Imperial College London, Department of Medicine, London W12 0NN, United Kingdom – sequence: 15 givenname: Natalia L. surname: Klyachko fullname: Klyachko, Natalia L. organization: Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, 1, 3, Moscow 119991, Russia – sequence: 16 givenname: Alexander G. orcidid: 0000-0002-5184-5551 surname: Majouga fullname: Majouga, Alexander G. organization: National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia, Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, 1, 3, Moscow 119991, Russia, D. Mendeleev University of Chemical Technology of Russia, Miusskaya Square, 9, Moscow 125047, Russia – sequence: 17 givenname: Yuri E. surname: Korchev fullname: Korchev, Yuri E. organization: National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia, Imperial College London, Department of Medicine, London W12 0NN, United Kingdom – sequence: 18 givenname: Alexander S. surname: Erofeev fullname: Erofeev, Alexander S. organization: National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia, Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, 1, 3, Moscow 119991, Russia |
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| SubjectTerms | Analytical chemistry Animals Antineoplastic Agents - pharmacology Antineoplastic drugs Antitumor agents Biosensing Techniques Cancer cancer therapy Cell Line, Tumor Chemistry Chemotherapy Doxorubicin Doxorubicin - pharmacology Drug development drug therapy Drugs Electrochemical Techniques Electrochemistry Humans Intracellular mechanism of action Mice neoplasms Neoplasms, Experimental - diagnosis Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism PC-3 Cells Reactive oxygen species Reactive Oxygen Species - analysis Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Tumors |
| Title | In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs |
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