ERβ isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates

• Published in: The Journal of pathology Vol. 207; no. 1; pp. 53 - 60
• Main Authors: Wong, Newton ACS, Malcomson, Roger DG, Jodrell, Duncan I, Groome, Nigel P, Harrison, David J, Saunders, Philippa TK
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.09.2005; Wiley
• Subjects: Biological and medical sciences; colorectal carcinoma; Gastroenterology. Liver. Pancreas. Abdomen; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; microsatellite instability; oestrogen receptor β; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; prognosis; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; microsatellite instability; Molecular form; Rectal disease; Prognosis; Colorectal carcinoma; Colorectal cancer; Estrogen; Malignant tumor; In vitro; Ovarian hormone; Colonic disease; In vivo; Anatomic pathology; Microsatellite DNA; oestrogen receptor β; Digestive diseases; Intestinal disease; Instability; Sex steroid hormone; Hormonal receptor

Colorectal carcinoma shows several sex‐related differences with regard to incidence, response to chemotherapy and microsatellite instability. These differences may relate to differential expression of ERβ1 (wild‐type) as well as the truncated ERβ2 and ERβ5 splice variant isoforms, which have recentl...