Punicalagin, a Pomegranate‐Derived Ellagitannin, Suppresses Obesity and Obesity‐Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway
Scope Punicalagin (PCG) is one of the most abundant phytochemicals found in pomegranates. The effects and mechanistic action of PCG on obesity and obesity‐induced inflammatory and oxidant responses are investigated in vitro and in vivo. Methods and results The effect of PCG on adipogenesis is examin...
Saved in:
Published in | Molecular nutrition & food research Vol. 63; no. 22; pp. e1900574 - n/a |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Wiley Subscription Services, Inc
01.11.2019
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Scope
Punicalagin (PCG) is one of the most abundant phytochemicals found in pomegranates. The effects and mechanistic action of PCG on obesity and obesity‐induced inflammatory and oxidant responses are investigated in vitro and in vivo.
Methods and results
The effect of PCG on adipogenesis is examined using Oil red O staining. The effects and mechanism of action of PCG on inflammatory responses are determined in adipocyte‐conditioned medium (ACM)‐cultured macrophages, a cell‐to‐cell contact system, and a transwell system. The effects of PCG on obesity and obesity‐induced inflammatory/oxidant responses are examined in high‐fat diet (HFD)‐fed mice. PCG effectively suppresses lipid accumulation in adipocytes and adipocyte‐induced inflammatory responses in adipocyte‐macrophage co‐culture systems. Small interfering RNA (siRNA) transfection indicates that the PCG‐mediated anti‐inflammatory effect is exerted via the nuclear factor erythroid 2‐related factor 2/Kelch‐like ECH‐associated protein 1(Nrf2/Keap1) pathway. PCG administration results in a significant reduction in body and white adipose tissue (WAT) weights. PCG favorably regulates pro‐ and anti‐inflammatory cytokines, downregulating nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB). Immunohistochemical (IHC) analysis demonstrates that PCG differentially modulates the distribution of complement component 3 receptor 4 subunit (CD11c) and cluster of differentiation 206 (CD206). PCG regulates the level of antioxidant and oxidant molecules by activating Nrf2/Keap1 signaling.
Conclusions
PCG ameliorates obesity and obesity‐induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity‐mediated diseases.
Punicalagin (PCG) ameliorates obesity and obesity‐induced inflammatory/oxidative responses in vitro and in vivo. PCG‐mediated suppression of obesity‐induced inflammatory/oxidative responses is due to the activation of the Nrf2/Keap1 signaling pathway. The PCG‐mediated anti‐inflammatory response in obesity is involved in the regulation of M1 and M2 phenotypes. |
---|---|
AbstractList | SCOPEPunicalagin (PCG) is one of the most abundant phytochemicals found in pomegranates. The effects and mechanistic action of PCG on obesity and obesity-induced inflammatory and oxidant responses are investigated in vitro and in vivo. METHODS AND RESULTSThe effect of PCG on adipogenesis is examined using Oil red O staining. The effects and mechanism of action of PCG on inflammatory responses are determined in adipocyte-conditioned medium (ACM)-cultured macrophages, a cell-to-cell contact system, and a transwell system. The effects of PCG on obesity and obesity-induced inflammatory/oxidant responses are examined in high-fat diet (HFD)-fed mice. PCG effectively suppresses lipid accumulation in adipocytes and adipocyte-induced inflammatory responses in adipocyte-macrophage co-culture systems. Small interfering RNA (siRNA) transfection indicates that the PCG-mediated anti-inflammatory effect is exerted via the nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1(Nrf2/Keap1) pathway. PCG administration results in a significant reduction in body and white adipose tissue (WAT) weights. PCG favorably regulates pro- and anti-inflammatory cytokines, downregulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Immunohistochemical (IHC) analysis demonstrates that PCG differentially modulates the distribution of complement component 3 receptor 4 subunit (CD11c) and cluster of differentiation 206 (CD206). PCG regulates the level of antioxidant and oxidant molecules by activating Nrf2/Keap1 signaling. CONCLUSIONSPCG ameliorates obesity and obesity-induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity-mediated diseases. Scope Punicalagin (PCG) is one of the most abundant phytochemicals found in pomegranates. The effects and mechanistic action of PCG on obesity and obesity‐induced inflammatory and oxidant responses are investigated in vitro and in vivo. Methods and results The effect of PCG on adipogenesis is examined using Oil red O staining. The effects and mechanism of action of PCG on inflammatory responses are determined in adipocyte‐conditioned medium (ACM)‐cultured macrophages, a cell‐to‐cell contact system, and a transwell system. The effects of PCG on obesity and obesity‐induced inflammatory/oxidant responses are examined in high‐fat diet (HFD)‐fed mice. PCG effectively suppresses lipid accumulation in adipocytes and adipocyte‐induced inflammatory responses in adipocyte‐macrophage co‐culture systems. Small interfering RNA (siRNA) transfection indicates that the PCG‐mediated anti‐inflammatory effect is exerted via the nuclear factor erythroid 2‐related factor 2/Kelch‐like ECH‐associated protein 1(Nrf2/Keap1) pathway. PCG administration results in a significant reduction in body and white adipose tissue (WAT) weights. PCG favorably regulates pro‐ and anti‐inflammatory cytokines, downregulating nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB). Immunohistochemical (IHC) analysis demonstrates that PCG differentially modulates the distribution of complement component 3 receptor 4 subunit (CD11c) and cluster of differentiation 206 (CD206). PCG regulates the level of antioxidant and oxidant molecules by activating Nrf2/Keap1 signaling. Conclusions PCG ameliorates obesity and obesity‐induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity‐mediated diseases. Punicalagin (PCG) ameliorates obesity and obesity‐induced inflammatory/oxidative responses in vitro and in vivo. PCG‐mediated suppression of obesity‐induced inflammatory/oxidative responses is due to the activation of the Nrf2/Keap1 signaling pathway. The PCG‐mediated anti‐inflammatory response in obesity is involved in the regulation of M1 and M2 phenotypes. Scope Punicalagin (PCG) is one of the most abundant phytochemicals found in pomegranates. The effects and mechanistic action of PCG on obesity and obesity‐induced inflammatory and oxidant responses are investigated in vitro and in vivo. Methods and results The effect of PCG on adipogenesis is examined using Oil red O staining. The effects and mechanism of action of PCG on inflammatory responses are determined in adipocyte‐conditioned medium (ACM)‐cultured macrophages, a cell‐to‐cell contact system, and a transwell system. The effects of PCG on obesity and obesity‐induced inflammatory/oxidant responses are examined in high‐fat diet (HFD)‐fed mice. PCG effectively suppresses lipid accumulation in adipocytes and adipocyte‐induced inflammatory responses in adipocyte‐macrophage co‐culture systems. Small interfering RNA (siRNA) transfection indicates that the PCG‐mediated anti‐inflammatory effect is exerted via the nuclear factor erythroid 2‐related factor 2/Kelch‐like ECH‐associated protein 1(Nrf2/Keap1) pathway. PCG administration results in a significant reduction in body and white adipose tissue (WAT) weights. PCG favorably regulates pro‐ and anti‐inflammatory cytokines, downregulating nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB). Immunohistochemical (IHC) analysis demonstrates that PCG differentially modulates the distribution of complement component 3 receptor 4 subunit (CD11c) and cluster of differentiation 206 (CD206). PCG regulates the level of antioxidant and oxidant molecules by activating Nrf2/Keap1 signaling. Conclusions PCG ameliorates obesity and obesity‐induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity‐mediated diseases. Punicalagin (PCG) is one of the most abundant phytochemicals found in pomegranates. The effects and mechanistic action of PCG on obesity and obesity-induced inflammatory and oxidant responses are investigated in vitro and in vivo. The effect of PCG on adipogenesis is examined using Oil red O staining. The effects and mechanism of action of PCG on inflammatory responses are determined in adipocyte-conditioned medium (ACM)-cultured macrophages, a cell-to-cell contact system, and a transwell system. The effects of PCG on obesity and obesity-induced inflammatory/oxidant responses are examined in high-fat diet (HFD)-fed mice. PCG effectively suppresses lipid accumulation in adipocytes and adipocyte-induced inflammatory responses in adipocyte-macrophage co-culture systems. Small interfering RNA (siRNA) transfection indicates that the PCG-mediated anti-inflammatory effect is exerted via the nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1(Nrf2/Keap1) pathway. PCG administration results in a significant reduction in body and white adipose tissue (WAT) weights. PCG favorably regulates pro- and anti-inflammatory cytokines, downregulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Immunohistochemical (IHC) analysis demonstrates that PCG differentially modulates the distribution of complement component 3 receptor 4 subunit (CD11c) and cluster of differentiation 206 (CD206). PCG regulates the level of antioxidant and oxidant molecules by activating Nrf2/Keap1 signaling. PCG ameliorates obesity and obesity-induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity-mediated diseases. |
Author | Hwang, Jisu Suh, Hyung Joo Jo, Kyungae Kim, Singeun Choi, Hyeon‐Son Kim, Chae Young Kang, Bobin |
Author_xml | – sequence: 1 givenname: Bobin surname: Kang fullname: Kang, Bobin organization: Korea University – sequence: 2 givenname: Chae Young surname: Kim fullname: Kim, Chae Young organization: Korea University – sequence: 3 givenname: Jisu surname: Hwang fullname: Hwang, Jisu organization: Korea University – sequence: 4 givenname: Kyungae surname: Jo fullname: Jo, Kyungae organization: Korea University – sequence: 5 givenname: Singeun surname: Kim fullname: Kim, Singeun organization: Korea University – sequence: 6 givenname: Hyung Joo surname: Suh fullname: Suh, Hyung Joo organization: Korea University – sequence: 7 givenname: Hyeon‐Son orcidid: 0000-0002-0165-7886 surname: Choi fullname: Choi, Hyeon‐Son email: hschoi@swu.ac.kr organization: Seoul Women's University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31444955$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkU1v1DAQhi1URD_gyhFZ4sKhu7Xjj2yOqLRlRWlXLXCNJvF46ypxgp1Q7Y2fwI3_xy_B0bZ74MJpZqTnfTUz7yHZ851HQl5zNueMZSett2GeMV4wpnL5jBxwzcVMciH2dn2m9slhjPeMCZ5J8YLsCy6lLJQ6IL9Xo3c1NLB2_pgCXXUtrgN4GPDPz18fMLgfaOhZMwEDeD9Rt2PfB4wRI72uMLphQ8Gbpz7Jlt6MdZItvW2gbWHowobeYOw7P4m-OaDDHdKrYLOTTwg9p7du7aFxfk1XMNw9wOYleW6hifjqsR6Rr-dnX04_zi6vL5an7y9ntdCLfKZqVuuCa6isVFktc8WtNsJUZqGtBkSTBos615U01nALVuagFliIXFbAxBF5t_XtQ_d9xDiUrYs1pns9dmMss2whlUr_zBP69h_0vhtDWjtRQvC8EJkuEjXfUnXoYgxoyz64FsKm5KycIiunyMpdZEnw5tF2rFo0O_wpowTILfDgGtz8x678fHV-IzTLxV-NA6hW |
CitedBy_id | crossref_primary_10_1016_j_phyplu_2022_100313 crossref_primary_10_1002_mnfr_202000312 crossref_primary_10_3390_jcm11226724 crossref_primary_10_1039_D2FO01552H crossref_primary_10_3390_antiox10020192 crossref_primary_10_3390_molecules26237238 crossref_primary_10_5812_gct_138980 crossref_primary_10_2174_1389557522666211229112223 crossref_primary_10_3390_nu16040506 crossref_primary_10_3390_antiox11102067 crossref_primary_10_3390_antiox9060473 crossref_primary_10_1042_BSR20212196 crossref_primary_10_2174_2211536610666210716153929 crossref_primary_10_1016_j_jep_2021_113847 crossref_primary_10_3390_antiox9070573 crossref_primary_10_1080_10408398_2023_2219763 crossref_primary_10_1016_j_arr_2021_101268 crossref_primary_10_1016_j_lfs_2023_122252 crossref_primary_10_3390_foods9030368 crossref_primary_10_1021_acs_jafc_1c04849 crossref_primary_10_1039_D3FO00286A crossref_primary_10_1016_j_supflu_2021_105300 crossref_primary_10_26599_FSHW_2022_9250123 crossref_primary_10_3390_ijms22116110 crossref_primary_10_1039_D0FO01545H crossref_primary_10_1002_mnfr_202001031 crossref_primary_10_1016_j_yexcr_2023_113717 crossref_primary_10_1007_s12257_020_0149_8 crossref_primary_10_3390_nano12030368 crossref_primary_10_3390_nu14091879 crossref_primary_10_1016_j_fbio_2023_102629 crossref_primary_10_3390_ph16030342 crossref_primary_10_1016_j_phrs_2021_105853 |
Cites_doi | 10.1038/nm0302-240 10.1007/s11154-014-9305-9 10.1039/C5FO00426H 10.1111/j.1541-4337.2010.00131.x 10.1016/j.jnutbio.2016.02.003 10.1042/CS20150436 10.3390/ijms12053117 10.1016/j.pneurobio.2012.09.003 10.1016/j.bbamcr.2008.01.002 10.1172/JCI29881 10.1016/j.foodchem.2011.11.106 10.1016/j.jep.2006.09.006 10.1248/bpb.b18-00064 10.2337/db08-1475 10.1016/j.bbrc.2017.03.119 10.1021/jf000404a 10.1021/jf020842c 10.4110/in.2006.6.4.169 10.1155/2013/789764 10.1172/JCI92035 10.1016/j.biopha.2018.09.169 10.1016/j.fct.2009.01.031 10.1016/j.fct.2008.04.035 10.1007/s00018-016-2223-0 10.1038/ncomms11624 10.1021/jf071689v 10.1155/2018/8917804 10.1016/j.phrs.2015.04.008 10.1248/bpb.b17-00837 10.1172/JCI21625 10.1080/10408391003748100 10.1111/avj.12745 10.1155/2013/184598 10.1124/dmd.104.002824 10.1111/j.1365-2443.2010.01473.x 10.1002/mnfr.201500490 10.1016/S0753-3322(02)00205-6 |
ContentType | Journal Article |
Copyright | 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Copyright_xml | – notice: 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim – notice: 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
DBID | NPM AAYXX CITATION 7QO 7QP 7T5 7T7 7TK 8FD C1K FR3 H94 P64 7X8 |
DOI | 10.1002/mnfr.201900574 |
DatabaseName | PubMed CrossRef Biotechnology Research Abstracts Calcium & Calcified Tissue Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitle | PubMed CrossRef Biotechnology Research Abstracts Technology Research Database AIDS and Cancer Research Abstracts Immunology Abstracts Engineering Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic CrossRef PubMed Biotechnology Research Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Diet & Clinical Nutrition |
EISSN | 1613-4133 |
EndPage | n/a |
ExternalDocumentID | 10_1002_mnfr_201900574 31444955 MNFR3607 |
Genre | article Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 123 1L6 1OC 31~ 33P 3SF 3WU 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHBH AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCUV ABIJN ABJNI ABPVW ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACIWK ACPOU ACPRK ACXBN ACXQS ADBBV ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AITYG AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ATUGU AUFTA AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BY8 C45 CS3 D-E D-F DCZOG DPXWK DR2 DRFUL DRSTM DU5 EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE G-S G.N GNP GODZA H.T H.X HF~ HGLYW HHZ HVGLF HZ~ IX1 J0M JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2W P2X P4D Q.N Q11 QB0 QRW R.K ROL RWI RX1 RYL SUPJJ SV3 TEORI UB1 V8K W8V W99 WBKPD WIH WIK WJL WNSPC WOHZO WXSBR WYISQ XG1 XV2 Y6R ~IA ~KM ~WT NPM AAYXX CITATION 7QO 7QP 7T5 7T7 7TK 8FD C1K FR3 H94 P64 7X8 |
ID | FETCH-LOGICAL-c3687-5c0c6916abf452c4751f6d3dbd86f6aeedd3dfe676b4dfd1faf47a58e9374ba03 |
IEDL.DBID | DR2 |
ISSN | 1613-4125 |
IngestDate | Sat Aug 17 01:01:09 EDT 2024 Fri Sep 13 08:32:17 EDT 2024 Fri Aug 23 02:20:19 EDT 2024 Sat Sep 28 08:31:01 EDT 2024 Sat Aug 24 01:12:14 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 22 |
Keywords | HFD-fed mice punicalagin Nrf2/Keap1 signaling obesity-induced inflammatory response co-culture obesity |
Language | English |
License | 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c3687-5c0c6916abf452c4751f6d3dbd86f6aeedd3dfe676b4dfd1faf47a58e9374ba03 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-0165-7886 |
PMID | 31444955 |
PQID | 2331793269 |
PQPubID | 2045123 |
PageCount | 12 |
ParticipantIDs | proquest_miscellaneous_2284554137 proquest_journals_2331793269 crossref_primary_10_1002_mnfr_201900574 pubmed_primary_31444955 wiley_primary_10_1002_mnfr_201900574_MNFR3607 |
PublicationCentury | 2000 |
PublicationDate | November 2019 2019-11-00 20191101 |
PublicationDateYYYYMMDD | 2019-11-01 |
PublicationDate_xml | – month: 11 year: 2019 text: November 2019 |
PublicationDecade | 2010 |
PublicationPlace | Germany |
PublicationPlace_xml | – name: Germany – name: Hoboken |
PublicationTitle | Molecular nutrition & food research |
PublicationTitleAlternate | Mol Nutr Food Res |
PublicationYear | 2019 |
Publisher | Wiley Subscription Services, Inc |
Publisher_xml | – name: Wiley Subscription Services, Inc |
References | 2009; 47 2015; 6 2015; 16 2000; 48 2018; 108 2004; 25 2015; 97 2002; 56 2002; 8 2016; 32 2013; 100 2006; 6 2016; 73 2018; 41 2011; 12 2015; 129 2011; 16 2007; 109 2003; 51 2007; 55 2009; 58 2016; 7 2012; 132 2018; 2018 2004; 114 2008; 1783 2007; 117 2013; 2013 2011; 51 2019 2008; 46 2018; 96 2016; 60 2017; 486 2005; 33 2017; 127 2010; 9 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_2_1 e_1_2_7_41_1 e_1_2_7_1_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 Ye M. (e_1_2_7_15_1) 2019 e_1_2_7_26_1 Sikaris K. A. (e_1_2_7_28_1) 2004; 25 e_1_2_7_29_1 e_1_2_7_30_1 e_1_2_7_31_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_22_1 El‐Beih N. M. (e_1_2_7_25_1) 2019 e_1_2_7_34_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_20_1 e_1_2_7_36_1 e_1_2_7_37_1 e_1_2_7_38_1 e_1_2_7_39_1 Pinheiro A. (e_1_2_7_27_1) 2018; 2018 |
References_xml | – volume: 96 start-page: 408 year: 2018 publication-title: Aust. Vet. J. – volume: 56 start-page: 276 year: 2002 publication-title: Biomed. Pharmacother. – volume: 48 start-page: 4581 year: 2000 publication-title: J. Agric. Food Chem. – volume: 73 start-page: 3221 year: 2016 publication-title: Cell. Mol. Life Sci. – volume: 2018 start-page: 1 year: 2018 publication-title: J. Immunol. Res. – volume: 51 start-page: 3493 year: 2003 publication-title: J. Agric. Food Chem. – volume: 32 start-page: 20 year: 2016 publication-title: J. Nutr. Biochem. – volume: 132 start-page: 1585 year: 2012 publication-title: Food Chem. – volume: 16 start-page: 123 year: 2011 publication-title: Genes Cells – volume: 25 start-page: 165 year: 2004 publication-title: Clin. Biochem. Rev. – year: 2019 publication-title: Biosci. Rep. – volume: 2018 year: 2018 publication-title: J. Immunol. Res. – volume: 7 year: 2016 publication-title: Nat. Commun. – volume: 47 start-page: 1085 year: 2009 publication-title: Food Chem. Toxicol. – volume: 58 start-page: 2574 year: 2009 publication-title: Diabetes – volume: 127 start-page: 1 year: 2017 publication-title: J. Clin. Invest. – volume: 129 start-page: 989 year: 2015 publication-title: Clin. Sci. – volume: 2013 start-page: 1 year: 2013 publication-title: Evidence‐Based Complement. Altern. Med. – volume: 486 start-page: 774 year: 2017 publication-title: Biochem. Biophys. Res. Commun. – volume: 46 start-page: 2728 year: 2008 publication-title: Food Chem. Toxicol. – volume: 51 start-page: 626 year: 2011 publication-title: Crit. Rev. Food Sci. Nutr. – volume: 60 start-page: 1139 year: 2016 publication-title: Mol. Nutr. Food Res. – volume: 55 year: 2007 publication-title: J. Agric. Food Chem. – volume: 1783 start-page: 713 year: 2008 publication-title: Biochim. Biophys. Acta‐Mol. Cell. Res. – volume: 114 start-page: 1752 year: 2004 publication-title: J. Clin. Invest. – volume: 9 start-page: 635 year: 2010 publication-title: Compr. Rev. Food Sci. Food Saf. – volume: 109 start-page: 177 year: 2007 publication-title: J. Ethnopharmacol. – volume: 41 start-page: 680 year: 2018 publication-title: Biol. Pharm. Bull. – volume: 33 start-page: 644 year: 2005 publication-title: Drug Metab. Dispos. – year: 2019 publication-title: Mol. Biol. Rep. – volume: 12 start-page: 3117 year: 2011 publication-title: Int. J. Mol. Sci. – volume: 117 start-page: 175 year: 2007 publication-title: J. Clin. Invest. – volume: 41 start-page: 1228 year: 2018 publication-title: Biol. Pharm. Bull. – volume: 97 start-page: 84 year: 2015 publication-title: Pharmacol. Res. – volume: 16 start-page: 35 year: 2015 publication-title: Rev. Endocr. Metab. Disord. – volume: 6 start-page: 169 year: 2006 publication-title: Immune Netw – volume: 108 start-page: 1507 year: 2018 publication-title: Biomed. Pharmacother. – volume: 100 start-page: 30 year: 2013 publication-title: Progr. Neurobiol. – volume: 6 start-page: 2049 year: 2015 publication-title: Food Funct. – volume: 2013 start-page: 1 year: 2013 publication-title: Oxid. Med. Cell. Longevity – volume: 8 start-page: 240 year: 2002 publication-title: Nat. Med. – ident: e_1_2_7_38_1 doi: 10.1038/nm0302-240 – ident: e_1_2_7_13_1 doi: 10.1007/s11154-014-9305-9 – ident: e_1_2_7_26_1 doi: 10.1039/C5FO00426H – ident: e_1_2_7_3_1 doi: 10.1111/j.1541-4337.2010.00131.x – ident: e_1_2_7_7_1 doi: 10.1016/j.jnutbio.2016.02.003 – ident: e_1_2_7_11_1 doi: 10.1042/CS20150436 – ident: e_1_2_7_8_1 doi: 10.3390/ijms12053117 – ident: e_1_2_7_35_1 doi: 10.1016/j.pneurobio.2012.09.003 – ident: e_1_2_7_36_1 doi: 10.1016/j.bbamcr.2008.01.002 – ident: e_1_2_7_30_1 doi: 10.1172/JCI29881 – ident: e_1_2_7_4_1 doi: 10.1016/j.foodchem.2011.11.106 – ident: e_1_2_7_1_1 doi: 10.1016/j.jep.2006.09.006 – ident: e_1_2_7_18_1 doi: 10.1248/bpb.b18-00064 – year: 2019 ident: e_1_2_7_15_1 publication-title: Biosci. Rep. contributor: fullname: Ye M. – ident: e_1_2_7_32_1 doi: 10.2337/db08-1475 – ident: e_1_2_7_40_1 doi: 10.1016/j.bbrc.2017.03.119 – ident: e_1_2_7_5_1 doi: 10.1021/jf000404a – year: 2019 ident: e_1_2_7_25_1 publication-title: Mol. Biol. Rep. contributor: fullname: El‐Beih N. M. – ident: e_1_2_7_20_1 doi: 10.1021/jf020842c – ident: e_1_2_7_31_1 doi: 10.4110/in.2006.6.4.169 – ident: e_1_2_7_6_1 doi: 10.1155/2013/789764 – volume: 2018 start-page: 6879183 year: 2018 ident: e_1_2_7_27_1 publication-title: J. Immunol. Res. contributor: fullname: Pinheiro A. – ident: e_1_2_7_9_1 doi: 10.1172/JCI92035 – ident: e_1_2_7_17_1 doi: 10.1016/j.biopha.2018.09.169 – ident: e_1_2_7_21_1 doi: 10.1016/j.fct.2009.01.031 – ident: e_1_2_7_19_1 doi: 10.1016/j.fct.2008.04.035 – ident: e_1_2_7_34_1 doi: 10.1007/s00018-016-2223-0 – ident: e_1_2_7_37_1 doi: 10.1038/ncomms11624 – ident: e_1_2_7_22_1 doi: 10.1021/jf071689v – ident: e_1_2_7_33_1 doi: 10.1155/2018/8917804 – volume: 25 start-page: 165 year: 2004 ident: e_1_2_7_28_1 publication-title: Clin. Biochem. Rev. contributor: fullname: Sikaris K. A. – ident: e_1_2_7_39_1 doi: 10.1016/j.phrs.2015.04.008 – ident: e_1_2_7_16_1 doi: 10.1248/bpb.b17-00837 – ident: e_1_2_7_29_1 doi: 10.1172/JCI21625 – ident: e_1_2_7_2_1 doi: 10.1080/10408391003748100 – ident: e_1_2_7_24_1 doi: 10.1111/avj.12745 – ident: e_1_2_7_12_1 doi: 10.1155/2013/184598 – ident: e_1_2_7_23_1 doi: 10.1124/dmd.104.002824 – ident: e_1_2_7_10_1 doi: 10.1111/j.1365-2443.2010.01473.x – ident: e_1_2_7_14_1 doi: 10.1002/mnfr.201500490 – ident: e_1_2_7_41_1 doi: 10.1016/S0753-3322(02)00205-6 |
SSID | ssj0031243 |
Score | 2.4767942 |
Snippet | Scope
Punicalagin (PCG) is one of the most abundant phytochemicals found in pomegranates. The effects and mechanistic action of PCG on obesity and... Punicalagin (PCG) is one of the most abundant phytochemicals found in pomegranates. The effects and mechanistic action of PCG on obesity and obesity-induced... ScopePunicalagin (PCG) is one of the most abundant phytochemicals found in pomegranates. The effects and mechanistic action of PCG on obesity and... SCOPEPunicalagin (PCG) is one of the most abundant phytochemicals found in pomegranates. The effects and mechanistic action of PCG on obesity and... |
SourceID | proquest crossref pubmed wiley |
SourceType | Aggregation Database Index Database Publisher |
StartPage | e1900574 |
SubjectTerms | Adipocytes Adipogenesis Adipose tissue Antioxidants CD11c antigen Cell culture co‐culture Cytokines HFD‐fed mice High fat diet In vitro methods and tests In vivo methods and tests Inflammation Lipids Lymphocytes B Macrophages Nrf2/Keap1 signaling Obesity obesity‐induced inflammatory response Oils & fats Oxidants Oxidizing agents Pomegranates punicalagin Signal transduction Signaling siRNA Transfection |
Title | Punicalagin, a Pomegranate‐Derived Ellagitannin, Suppresses Obesity and Obesity‐Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmnfr.201900574 https://www.ncbi.nlm.nih.gov/pubmed/31444955 https://www.proquest.com/docview/2331793269/abstract/ https://search.proquest.com/docview/2284554137 |
Volume | 63 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9NAEF6hnrjwfhgKWiQEl7qx95kcEW1UQI2iQFFv1j6rqMmmahwQnPgJ3Ph__BJm1w8IHBDi5seOvbZndr5Zz36D0FPFNGdMyVyy0TBnyhe5tpTnhkhCVCm19XEe8ngijk7Y61N--ssq_oYfop9wi5aRxuto4EqvBz9JQ5fBRz5PcGgAOSIhaGTTi6ho1vNHUXBeKcMefFbOwJV3rI0FGWyLb3ulP6DmNnJNrmd8Hamu003Gyfn-ptb75vNvfI7_81Q30LUWl-IXjSLdRFdcuIWyg7mr8TPckocu8KTj7r-Nvk3TupJFrHK0hxWerpaRdyIAdv3-5esBKPYHZ_HhIjaoU2GkPRxLiCay8jVuCxJgFWy3DWKxkIgBsVfBg6YuUwYAnjVpvCD0fq4wAFY8ufRk8MapixK_nZ_FUCKc4Slg2Y_q0x10Mj589_Iob6s85IYKGOG4KYwAkKq0Z5wYJnnphaVW26HwQoEPhx3vhBSaWW9LrzyTig8dACumVUHvop2wCu4-woXm1ukYw3nJhlxDLGcNNXSkKXPOjzL0vPvK1UVD5lE1tM2kii--6l98hnY7Jahao15XhNI4nBEBF3rSnwZzjP9YVHCrDbQBdw8IraQyQ_ca5elvRSF4hXiUZyhPKvCXPlTHk_GMikI--Mf2D9HVeLBZMbmLdurLjXsE0KnWj5N5_AAUKhbM |
link.rule.ids | 315,786,790,1382,27957,27958,46329,46753 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9NAEF5BOcAFyttQYJEQXOrG9r6SI6KNUtpYUWgRN2ufVUTiVK0Doqf-hN74f_wSZtcPFDggxM2Wd-z1embnm_XsNwi9klQxSqWIBR30YypdEitDWKwzkWUyFco4vw45zvnomL7_xNpsQr8XpuaH6BbcvGWE-dobuF-Q7v1iDV2UzhN6gkcDzEGvoxtg8yxEVdOOQYqA-wo59uC1YgrOvOVtTLLeuvy6X_oDbK5j1-B8hneQartd55x83llVakdf_Mbo-F_vtYluN9AUv6116S66Zst7KNqd2Qq_xg1_6BznLX3_ffR9EraWzH2ho20s8WS58NQTJcDXH5dXu6DbX6zBe3PfoAq1kbaxryIa-MrPcVOTAMvStMcg5muJaBDbLx0o6yIkAeBpnckLQh9nEgNmxfmZy3oHVp6m-MPsxEcT5QmeAJz9Kr89QMfDvaN3o7gp9BBrwmGSYzrRHHCqVI6yTFPBUscNMcr0ueMS3DicOMsFV9Q4kzrpqJCsbwFbUSUT8hBtlMvSPkY4UcxY5cM4J2ifKQjnjCaaDBSh1rpBhN60n7k4rfk8ipq5OSv8wBfdwEdoq9WCorHr8yIjxM9oGYcbvewug0X63yyytMsVtAGPDyAtJSJCj2rt6R5FIH6FkJRFKA468Jc-FON8OCU8EU_-sf0LdHN0ND4sDvfzg6folm9Qb6DcQhvV2co-AyRVqefBVn4Cd9Ea7g |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9NAEF5BkRAXKG9DgUVCcKkbe5_JEZFGLaVWFCjqzdpnFZE4UeuA6Kk_oTf-H7-EWb8gcECImy3v2Ov1zM4369lvEHqhmOaMKRlLNujHTPkk1pby2BBJiEqltj6sQx5mYu-IvT3mx7_s4q_5IboFt2AZ1XwdDHxpfe8naei88IHPExwaQA52FV1jgpKg18NJRyBFwXtVKfbgtGIGvrylbUxIb11-3S39gTXXoWvle0a3kGp7XaecfNpZlXrHnP9G6Pg_r7WJbjbAFL-uNek2uuKKOygaTl2JX-KGPXSGs5a8_y76Nq42lsxCmaNtrPB4MQ_EEwWA1-8Xl0PQ7M_O4t1ZaFBWlZG2caghWrGVn-GmIgFWhW2PQSxUEjEgtl94UNV5lQKAJ3UeLwh9nCoMiBVnp570Dpxapvj99CTEEsUJHgOY_aK-3kNHo90Pb_bipsxDbKiAKY6bxAhAqUp7xolhkqdeWGq17QsvFDhxOPFOSKGZ9Tb1yjOpeN8BsmJaJfQ-2igWhXuIcKK5dToEcV6yPtcQzFlDDR1oypzzgwi9ar9yvqzZPPKat5nkYeDzbuAjtNUqQd5Y9VlOKA3zGRFwo-fdZbDH8JNFFW6xgjbg7wGipVRG6EGtPN2jKESvEJDyCMWVCvylD_lhNppQkchH_9j-Gbo-Ho7yd_vZwWN0I1yvd09uoY3ydOWeAIwq9dPKUn4AHloZnQ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Punicalagin%2C+a+Pomegranate-Derived+Ellagitannin%2C+Suppresses+Obesity+and+Obesity-Induced+Inflammatory+Responses+Via+the+Nrf2%2FKeap1+Signaling+Pathway&rft.jtitle=Molecular+nutrition+%26+food+research&rft.au=Kang%2C+Bobin&rft.au=Kim%2C+Chae+Young&rft.au=Hwang%2C+Jisu&rft.au=Jo%2C+Kyungae&rft.date=2019-11-01&rft.eissn=1613-4133&rft.volume=63&rft.issue=22&rft.spage=e1900574&rft.epage=e1900574&rft_id=info:doi/10.1002%2Fmnfr.201900574&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1613-4125&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1613-4125&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1613-4125&client=summon |